I-HPMC HYDROXYPROPYLL Methylcellulose, eyaziwa nangokuthi i-Hypromellose, ingenye ye-Non-Ioldel Cellose Afesfer. Kuyinto esetshenziswayo, engasebenzi, i-polymer esetshenziswayo esetshenziswa kakhulu njengokuthambisa ku-ophthalmology, noma njenge-excipient noma i-excipoint emithini yomlomo.
Igama lomkhiqizo i-hydroxypropyllylylylylylylylylylylylyllylylylyllll (HPMC)
Elinye igama hydroxypropylllylylylyllose, MHPC, Methyl hydroxyprosellllloseli
Inombolo yokubhalisa ye-CAS 9004-65-3
Ukubukeka okumhlophe okumhlophe noma kwe-granular powder
Incazelo Yokuphepha S24 / 25
Izakhiwo zenyama nezamakhemikhali
Ukubukeka: Kumhlophe noma cishe okumhlophe noma okumhlophe
Ukuqina: Ama-Solids ayavutha futhi ahambelana ne-oxidants eqinile.
Granularity; Izinga lokuphasa le-100 mesh lalingaphezu kwama-98.5%. Izinga lokuphasa kwamehlo angama-80 liyi-100%. Usayizi okhethekile wesayizi yezinhlayiya eziyishumi 40 ~ 60 mesh.
Izinga lokushisa le-carbonization: 280-300 ℃
Ukubukeka okusobala: 0.25-0.70g / cm3 (imvamisa ezungeze i-0.5g / cm3), amandla adonsela phansi athile 1.26-1.31.
Ukushisa kombala okuguqukayo: 190-200 ℃
Ukungezwani komhlaba: 42-5dyne / cm ngesisombululo esingamanzi esingu-2%
I-Solubity: incibilika emanzini kanye namanye ama-solvents athile, njengengxenye efanele ye-ethanol / wamanzi, i-propapol / amanzi, njll. Isixazululo esinamanzi sinomsebenzi ongaphezulu. Ukucaca okuphezulu, ukusebenza okuzinzile, ukucaciswa okuhlukile kokushisa kwe-gel yomkhiqizo kuhlukile, kushintshwa ngokusobala, okucacisiwe kokusebenza kwe-HPMC, isixazululo esihlukile sokusebenza kwamanzi sinomthelela othile.
Umsebenzi wobubanzi be-HPMC wehlile ngokuncipha kokuqukethwe kwe-methoxyl, ukwanda kwe-gel point kanye nokuncipha kwe-soubity yamanzi.
I-HPMC ibuye ibe nekhono elikhulayo, ukumelana nosawoti okuphansi kwe-ash powder, ukuqina kwe-PH, ukugcinwa kwamanzi, ukuqina okubucayi, ukwakheka okuhlukahlukene kwefilimu, kanye nohlu olubanzi lokumelana ne-enzyme, ukusabalalisa kanye nezimpawu zokubopha izibopho.
Izindlela Zokukhiqiza
I-cellulose yekotini ecwengekile iphathwa ngo-35- 40 ℃ isigamu sesigamu sehora, icindezelwe, i-cellulose ichotshozwa futhi ineminyaka engu-35 ℃, ukuze isilinganiso se-polymerization fiber esitholwayo ngaphakathi kwebanga elidingekayo. Beka i-alkali fiber ku-kettle yokuthethelwa, engeza i-propelene oxide kanye ne-methane chloride ngokulandelana, etherize ngo-50-80 ℃ ngo-5h, ukucindezela okuphezulu kakhulu kumayelana ne-1.8MPA. Ngemuva kwalokho engeza inani elifanele le-hydrochloric acid kanye nezinto zokugeza acid ze-oxalic kumanzi ashisayo angama-90 ℃ ukukhulisa ivolumu. Lapho okuqukethwe kwamanzi okuqukethwe kungaphansi kwama-60%, yomiswa ngaphansi kwama-5% ngokugeleza komoya okushisayo ngo-130 ℃. Ekugcineni, umkhiqizo oqediwe uchotshozwa futhi uhlolwe nge-20 mesh.
Indlela yokuchithwa
1, wonke amamodeli angangezwa kulokho okwenziwe ngendlela eyomile yokuxuba.
2, kudingeka ukuthi wengezwe ngqo kwisixazululo samanzi esijwayelekile sokushisa, kungcono ukusebenzisa ukuhanjiswa kwamanzi okubandayo, ngemuva kokungeza imizuzu eyi-10-90 ukuqina.
3. Amamodeli ajwayelekile angancibilika ngemuva kokuxuba futhi ahlakaze ngamanzi ashisayo futhi angeze amanzi abandayo ngemuva kokuvusa nokupholisa.
4. Lapho kuchithwa, uma kwenzeka into ye-agglomerating yenzeka, kungenxa yokuthi ukuxubana akuyona amamodeli anele noma ajwayelekile angezwe ngqo emanzini abandayo. Ngalesi sikhathi, kufanele kuvuswe ngokushesha.
5
I-HPMC isebenzisa
Isetshenziswa njenge-khulu, i-distrantint, i-binder, excy, ukumelana kawoyela, ukucwilisa, i-emulsifier ne-spintilizer embonini yezindwangu. Isetshenziswa kabanzi ku-sonthetic resin, i-petrochemical, ceramic, iphepha, isikhumba, umuthi, ukudla nezimonyo kanye nezinye izimboni.
Inhloso Eyinhloko
1, Imboni Yokwakha: Njengomphathi we-cander water water Returtuntion Agent, udaka lwe-retarder ngokupompa. Ekuhlolweni, i-gypsum, i-putty powder noma ezinye izinto zokwakha njengokunamathela, yenza ngcono i-daub nokwandisa isikhathi sokusebenza. Isetshenziselwa ukunamathisela i-ceramic tile, imabula, umhlobiso wepulasitiki, unamathisela i-ejenti yokuqinisa, namanje kunganciphisa umthamo kasimende. Ukusebenza kwamanzi okugcinwa kwamanzi kwe-HPMC kwenza ukuthi ama-slurry ngemuva kokuthi afake isicelo ngeke asome ngokushesha okukhulu futhi aqhekeke, athuthukise amandla ngemuva kokuqina.
2, ukukhiqiza ubumba - kusetshenziswe kabanzi njengokunamathela ekukhiqizweni komkhiqizo we-ceramic.
Imboni emi-3, embonini embonini: embonini we-coating njengomuntu omkhulu, ohlakazekile ne-stabilizer, emanzini noma ezihlathini ze-organic zine-solubity enhle. Njenge-remover yokupenda.
I-4, i-inki ukuphrinta: embonini ye-inki njengomuntu omkhulu, ohlakazekile ne-stabilizer, emanzini noma ezihlathini ze-organic zine-solubity enhle.
I-5, Plastic: Ekwakheni i-ejenti yokukhishwa, ithambile, i-lubricant, njll.
I-6, PVC: Ukukhiqizwa kwe-PVC njengokuhlakazwa, ukumiswa kwe-polymerization ukulungiswa kwePVC Main Auxiliaries.
7, imboni yezemithi: Izinto zokuhlanganisa; Indwangu ye-membrane; Izinto ezilawulwa kakhulu zokulawula ama-polymer zamalungiselelo wokukhulula okulondoloziwe; Umenzeli wokuzinza; Usizo Lokumiswa; Ukunamathela kwethebhulethi; Kwandisa goo
8, Abanye: Futhi basetshenziswa kabanzi kwizikhumba, imboni yephepha, ukulondolozwa kwezithelo kanye nokulondolozwa kwemifino kanye nemboni yezindwangu.
Isicelo esithile somkhakha
Imboni Yokwakha
1, uCinder Botar: Thuthukisa ukuhlakazwa kukasimende - isihlabathi, ukuthuthukisa kakhulu ipulasitiki nokugcinwa kwamanzi ngodaka, ukuvikela imifantu kube nomphumela, kungathuthukisa amandla kasimende.
2, I-Ceramic Tile Cement: Thuthukisa i-Plasticity of Ceramic Tile Daile, Ukugcinwa kwamanzi, ukuthuthukisa ukudluliselwa kweglue kwe-ceramic tile, vimba i-powder.
I-3, i-asbestos kanye nenye i-coating refracture: njenge-ejenti yokumiswa, umenzeli wokuthuthukisa we-liquidity, kodwa futhi uthuthukise isisekelo se-glue edluliselwe.
I-4, gypsum slurry: Thuthukisa ukugcinwa kwamanzi kanye nokusebenza, thuthukisa ukunamathela kwesisekelo.
I-5, usimende ohlanganisiwe: engeza ebhodini le-gypsum nge usimende ehlanganisiwe, uthuthukise uketshezi nokugcinwa kwamanzi.
I-6, i-latex putty: Thuthukisa ubuhlakani kanye nokugcinwa kwamanzi kwe-resin latex based putty.
I-7, udaka: njengomuntu obambele esikhundleni semvelo, kungathuthukisa ukugcinwa kwamanzi, ukuthuthukisa ukudluliselwa kweglue ngesisekelo.
I-8, i-coating: njengesositiki se-latex coating, ineqhaza ekwenzeni ngcono ukusebenza okusebenzayo kanye noxhaso lwe-coatity ne-putty powder.
9, Ukufafaza Coating: Ukuvimbela usimende noma i-latex sprafull kuphela i-filler ecwilisa futhi ithuthukise ukuhamba kanye nokufafaza ihluzo ze-beam zinomphumela omuhle.
I-10, Conment, Gypsum Secondary Products: Njengosesimende - Asbestos nezinye izinto ze-hydraulic ezicindezela i-binder binder, thuthukisa ububi, ungathola imikhiqizo yokubumba efanayo.
11, I-Fibrell Wall: Ngenxa ye-anti-enzyme anti-bacterial umphumela, njengoba isigaxa sodonga lwesihlabathi siyasebenza.
12, Okunye: Kungasetshenziswa njenge-Miningi Day Satar kanye neqhaza lomuntu ophethe udaka lwe-bubble ebambe ejele.
Imboni yamakhemikhali
1, i-vinyl chloride, i-vinyl polymerization: njengoba ukumiswa kwe-polymerization ukumiswa kwe-Stabilizer, Dispersant, ngotshwala be-vinyl (PVA) i-hydroxypropylll (hpc) i-hydroxypropylls (HPC) futhi ingalawula ukusatshalaliswa kwejayi lezinhlayiyana kanye nezinhlayiyana.
2, Adhesive: Njengoba ukunamathela kwesithombe, esikhundleni sesitashi kuvame ukusetshenziswa nge-vinyl acetate latex coating.
3. I-Pesticide: ingezwe kuma-insecticides kanye nama-herbicides, kungathuthukisa umphumela wokunamathela lapho ufafaza.
I-4, i-latex: Thuthukisa i-asphalt emulsiil stabilizer, i-styrene butadiene rubber (SBR) isikhunzi se-latex.
I-5, i-Binder: njengepensela, i-crayon yakha ukunamathela.
Imboni yezimonyo
1. I-Shampoo: Thuthukisa i-viscosity nokuqina kwama-bubble of shampoo, okokuhlanza kanye nokuhlanza.
2. Amazinyo
Imboni yokudla
1, I-Citrus Esekheni: Vimbela ukulondolozwa ngenxa yokubola kwama-glycosides we-orange kanye ne-metamorphism yamhlophe ukufeza okusha.
2, Imikhiqizo yezithelo ebandayo: Faka kumazolo wezithelo, i-Ice Medium, yenza ukunambitheka kube ngcono.
I-3, isoso: Njengesoso, isoso se-tomato u-anilsung spintilizer noma i-ejenti yokuqina.
I-4, ama-coating wamanzi abandayo: asetshenziselwa ukugcinwa kwezinhlanzi ezibandayo, angavimbela ukuhlukaniswa, ukuncishiswa kwekhwalithi, nge-methylrules noma i-hydroxypropylm noma i-hydroxypropyll methyl celtulose Solution ehlanganisiwe, bese iqhwa eqhweni.
I-5, ukunamathela kwamaphilisi: njengokwakheka kwamaphilisi namaphilisi, isibopho kanye nokuwa (kusincibilike ngokushesha futhi kusakazeke lapho kuthatha) kuhle.
Imboni yezemithi
1. I-Coating: I-ejenti ye-coating yenziwa esikhaleni se-organic solvent noma ikhambi lamanzi lamanzi, ikakhulukazi izinhlayiya ezenziwe nge-Spray Coating.
2, i-ejenti yehlise kancane: 2-3 ama-gramu ngosuku, isikhathi ngasinye isikhathi esingu-1-2g, ezinsukwini ezi-4-5 ukukhombisa umphumela.
3, umuthi wamehlo: ngoba ingcindezi ye-osmotic ye-hydroxyproppropylylylylylylyllylylyllyllyllopylyllylylylylylylylylylylylylylyllyllyllyrlopyllyllopyllop aqulose isixazululo, ngakho-ke incane emehlweni, engeza umuthi wamehlo, njenge-lubricant yokuxhumana ne-eyeball lens.
I-4, i-ejenti ye-gelatinous: Njengombhalo wesisekelo wezokwelapha noma amafutha angaphandle.
I-5, ifaka izidakamizwa: njenge-ejenti yokuqina, i-ejenti yokugcinwa kwamanzi.
Imboni Yezithando
1, Izinsizakusebenza ze-elekthronikhi: njenge-ceramic kagesi denser, i-bauxite Ferrite Pressure ingcindezi yokuzinamathela, ingasetshenziswa nge-1.2-plylene glycol.
2, glaze: Kusetshenziswe njenge-Curamic glaze kanye ne-porcelain nge-koqweqwe lwawo, kungathuthukisa ukuhlanganisa nokucubungula.
I-3, udaka oluzenzakalelayo: engeza ku-refractory ductartar noma impahla ye-cast winingle, ingathuthukisa ipulasitiki nokugcinwa kwamanzi.
Eminye Imboni
1, i-fiber: njengokuphrinta udayi wokuphrinta ama-pigment, amadayi e-boron ehlathini, amadayi asuselwa usawoti, udayi wezindwangu, ngaphezu kokusebenza kwe-kapok Ripple, angasetshenziswa nge-resin yokushisa i-resin.
I-2, Iphepha: Isetshenziselwa i-Carbon Paper Leather Gluing kanye nokucutshungulwa kwamafutha nezinye izici.
3, Isikhumba: Njengokugcina kokugcina noma ukusetshenziswa okunamathelayo.
I-4, uyinki esekwe emanzini
5, ugwayi: Njengokunamathela kogwayi ophindaphindwayo.
I-Pharmacopoeia Standard
Umthombo nokuqukethwe
Lo mkhiqizo ngu-2- hydroxypropyll ether methyl cellulose. IHydroxypropyllylylyl ihlukaniswe izinhlobo ezine ngokuya ngokuqukethwe kwe-methoxy ne-hydroxyproppy, okungu-2208, okungu-22210, okungu-2910, okuqukethwe yi-hydroxypropoxy (-Och10) kanye ne-hydroxypropoxy (-Och10)) kufanele kuhambisane nezinhlinzeko zethebula elinamathiselwe.
isimilo
Lo mkhiqizo ungumhlophe noma omhlophe we-quibrous noma omhlophe; Ngaphandle kwe-odorless.
Lo mkhiqizo ucishe wawungabonakali e-anom athanol, ether kanye ne-acetone; Ukuvuvukala emanzini abandayo ukwakha ikhambi elicacile noma elincanyana le-colloid.
Ukukhomba
(1) Thatha i-1g yomkhiqizo, ushise amanzi ayi-100ml (80 ~ 90 ℃), uvuse ngokuqhubekayo, upholile kubhavu weqhwa, bese wakhe uketshezi olunamathelayo; Beka i-2ML yesisombululo kushubhu lokuhlola, kancane kancane engeza i-1ml ye-0.035% anthracene sulfuric acid solution eduze kodonga lwe-tube, yibeke imizuzu engu-5, futhi indandatho eluhlaza okwesibhakabhaka ivela esibonakalayo phakathi kweziphuzo ezimbili.
(2) Inani elifanele loketshezi lwe-viscous ngaphansi kokuhlonza (1) lithululelwa epuletini lengilazi. Ngemuva kokuhwamuka kwamanzi, kwakhiwa ungqimba lwefilimu elinzima.
-hlola
1, ph
Ngemuva kokupholisa, lungisa isixazululo ku-100g ngamanzi bese uvusa kuze kuchithwe ngokuphelele. Nquma ngokomthetho (Isithasiselo ⅵ h, Ingxenye II ye-Pharmacopoeia, i-2010 Edition). Ivelu ye-PH kufanele ibe ngu-5.0-8.0.
2, I-Viscosity
I-2.0% (G / G) ukumiswa kwalungiswa ngokuthatha i-10.0g yomkhiqizo nokungeza amanzi angama-90 ℃ ukwenza isisindo esiphelele sesampula namanzi 500.0g njengomkhiqizo owomile. Ukumiswa kwavuselelwa ngokuphelele imizuzu eyi-10 kuze kube yilapho izinhlayiya zazihlakazeke ngokuphelele futhi zimanzi. Ukumiswa kwaphola kubhavu weqhwa futhi kwaqhubeka nokuvusa imizuzu engama-40 ngesikhathi senqubo yokupholisa. I-Viscosimeter eyodwa ye-Cylinder Rotary (NDJ-1 ingasetshenziselwa amasampula anokubonana okungaphansi kwe-100pa · Ama-viscosimeter angenayo, noma elinye i-viscosimeter efanelekile (indlela yesibili ye-ⅵ g ku-appendix II ka-2010 i-edition). Uma i-visualcoty ebilekwe ingaphansi kwama-600MPA S, i-viscosity kufanele ibe ngu-80% ~ 120% we-viscosity ebibelwe; Uma i-Viscosity Eleveli inkulu kakhulu noma ilingana ne-600MPA S, i-viscosity kufanele ibe ngo-75% kuya ku-140% we-viscosity ebibelwe.
3 udaba lokungena ngaphakathi emanzini
Thatha i-1.0g yomkhiqizo, ufake ku-beaker, engeza amanzi ashisayo angu-100ms ku-80-90 ℃, avuvukele imizuzu engu-15, engeza amanzi angu-300ml (uma kunesidingo, akhuphule ivolumu yamanzi ngokufanelekile ukuze uqinisekise ukuthi isixazululo siyahlungwa), sikuvuse ngokugcwele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, sihluphe ngokuphelele, wukuhlunga nge-cha. 1 Ingilazi eqinile ebiyele enobuhlakani obuye bomile ukuze kuhlale njalo ngo-105 ℃, futhi hlanza i-beaker ngamanzi. Uketshezi luhlungwa lungilazi olungenhla luncibilika olungenakuncipha futhi omiswe ngesisindo esingu-105 ℃, ngezinsalela eziyinsalela ezingadluli i-5mg (0.5%).
4 Ukwehla kwesisindo okusomile
Thatha lo mkhiqizo bese uyomisa ngo-105 ℃ amahora ama-2, futhi ukulahlekelwa isisindo ngeke kudlule u-5.0% (Isithasiselo ⅷ l, Ingxenye II, I-Pharmacopoeia 2010 Edition).
Izinsalela ezi-5 ezivuthayo
Thatha i-1.0g yalo mkhiqizo bese uyihlola ngokuya ngomthetho (Isithasiselo
6 insimbi esindayo
Thatha izinsalela ezisele ngaphansi kwezinsalela ze-incandescent, hlola ngokuhambisana nomthetho (indlela yesibili yesithasiselo
I-7 arsenic usawoti
Thatha i-1.0g yalo mkhiqizo, engeza i-1.0g calcium hydroxide, hlanganisa, engeza amanzi ukuze uvuse ngokulinganayo, bese ufaka umlilo omncane, uphinde ufake umlobi we-chordix, kufanele uhambisane neminye imitha (0.0002%).
Ukuzimisela kokuqukethwe
1, Methoxyl
I-Methoxy, i-ethoxy ne-hydroxypropoxy (i-appendix vii f, ingxenye II, uhlelo lwe-2010 lwe-pharmacopoeia) lwazimisele. Uma indlela yesibili (indlela ye-volumetric) isetshenziswa, thatha umkhiqizo, uyicabangele ngokunembe futhi ukukala ngokomthetho. Inani le-methoxy elinganiselwe (%) lidonswa kumkhiqizo wenani le-hydroxypropoxy (%) kanye (31/75 × 0.93).
2, i-hydroxypropoxy
I-Methoxy, i-ethoxy ne-hydroxypropoxy (i-appendix vii f, ingxenye II, uhlelo lwe-2010 lwe-pharmacopoeia) lwazimisele. Uma indlela yesibili (indlela yevolumu) isetshenziswa, thatha umkhiqizo mayelana ne-0.1G, isisindo ngokunembile, unqume ngokomthetho, futhi uthole.
I-pharmacology kanye ne-toxicology
I-Hydroxypropyllylylylylylyllllulose iyingxenye ye-cellulose methyl nengxenye ye-hydroxypropyll ether, ingachithwa emanzini abandayo ukwakha izinyembezi ze-viscoelastic (ikakhulukazi ama-mucin) asondelene nezinyembezi zokufakelwa. Indlela yokusebenza ukuthi i-polymer inamathela ebusweni beso nge-adsorption, ngaleyo ndlela enze isenzo sokuncishiswa kwe-conjunctival, ngaleyo ndlela sithuthukise isimo sokugcinwa kwamehlo esimweni sokuncishiswa kwezinyembezi. Le adsorption izimele ngokubonakala kwesixazululo futhi ngaleyo ndlela ivumela umphumela ongewona owomanzi ngisho nezixazululo ezisezingeni eliphansi. Ngaphezu kwalokho, ukumanzisa i-corneal kukhuphuke ngokunciphisa i-angle yokuxhumana yendawo ehlanzekile ye-corneal.
Pharmacokinetics
Ayikho imininingwane ye-pharmacokinetic okubikwe ukusetshenziswa kwe-topical kwalo mkhiqizo.
Izinkomba
Moisten ngamehlo ngemfihlo enganele ngezinyembezi futhi uqede ukungaphatheki kwamehlo.
Umsebenzi
Bobabili abadala nezingane bangayisebenzisa. Amaconsi ama-1-2, kathathu ngosuku; Noma njengoba kunqunywe ngudokotela.
Ukuphendula okuphikisayo Hlela inkulumo
Ezimweni ezingavamile kungadala ukungakhululeki kwamehlo okufana nobuhlungu bamehlo, umbono ofiphele, ukugcwala okuqhubekayo kwe-conjunctival noma ukucasulwa kwamehlo. Uma lezi zimpawu ezingenhla zisobala noma ziphikelela, yeka ukusebenzisa umuthi bese uya esibhedlela ukuze zihlolwe.
ithebaba
I-Contraindicated kubantu abangayilali kulo mkhiqizo.
Izindaba ezidinga ukunakwa
1. Ungathinti ikhanda le-Drop Bottle e-eyelid nakwezinye izindawo zokuvimbela ukungcoliswa
2. Sicela ugcine umkhiqizo ungafinyeleleki ezinganeni
3. Inyanga eyodwa ngemuva kokuvula ibhodlela, alifanele ukuqhubeka nokulisebenzisa.
4. Umuthi wokukhulelwa kanye nokuthambisa abesifazane: AKUKHO imibiko yomonakalo wokuzala noma ezinye izinkinga ezibangelwa yi-Hydroxypropyllloses emzimbeni womuntu; Akunakusabela okuphikisayo okubikwe ezinganeni ngesikhathi sokuqina. Ngakho-ke, akukho madikidi okhethekile wokukhulelwa nokuthambisa abesifazane.
I-5 Ngakho-ke, izingane kanye nabantu abadala bangasebenzisa lo mkhiqizo ngokuya ngohlelo olufanayo.
I-6, umuthi wabantu asebekhulile: ukusetshenziswa kwe-hydroxypropyllyly methylcellosise ezigulini ezikhulile, uma kuqhathaniswa namanye amaqembu eminyaka, akubangeli imiphumela emibi ehlukene noma ezinye izinkinga. Ngokuvumelana nalokhu, umuthi wesiguli osenesigqi awunawo umbango okhethekile.
7, Isitoreji: Isitoreji Somoya.
Ukusebenza Kwezokuphepha
Ubungozi bezeMpilo
Lo mkhiqizo uphephile futhi awunalo ubuthi, ungasetshenziswa njengezengezo zokudla, akukho ukushisa, akukho ukucasulwa kokuxhumana ngolwelwesi lwesikhumba kanye ne-mucous membrane. Ngokuvamile kubhekwa njengephephile (FDA1985). Ukuthathwa kwansuku zonke okuvumelekile kuyinto engama-25mg / kg (i-FA / WHO 1985). Imishini yokuvikela kufanele igqokwe ngesikhathi sokusebenza.
Umthelela wezemvelo
Gwema ukungcoliswa komoya okubangelwa uthuli ukundiza.
Izingozi Zomzimba Nezemiphakathi: Gwema Ukuxhumana Nemithombo Yemililo, futhi uvikele ukwakha uthuli olukhulu endaweni evaliwe ukuvikela izingozi eziqhumayo.
Izinto ezigciniwe zithunyelwe
Naka ukuvikelwa kwelanga emvuleni nasemswakama, gwema ukukhanya kwelanga okuqondile, okuvalwe endaweni eyomile.
Isikhathi sokuphepha
S24 / 25: Gwema ukuxhumana nesikhumba namehlo.
Gwema ukuxhumana nesikhumba namehlo.
Isikhathi sePosi: Dec-02-2021