Ake sikhulume nge-hydroxypropyl methyl cellulose HPMC nendlela yokukala i-viscosity yayo.I-viscosity lapha isho i-viscosity ebonakalayo, okuyinkomba ebalulekile ye-hydroxypropyl methyl cellulose.
Okujwayelekile.Izindlela zokulinganisa ezijwayelekile ukulinganisa i-viscosity ejikelezayo, ukulinganisa kwe-capillary viscosity kanye nokulinganisa kokuwa kwe-viscosity.Indlela yokunquma ye-hydroxypropyl methyl cellulose kwakuyi-capillary adhesion.
Indlela yokunquma idigri, kusetshenziswa i-Uchs viscometer.Ngokuvamile ukunqunywa kwesisombululo kuba yisixazululo esingu-2% samanzi, ifomula ithi: V=Kdt.I-V yi-viscosity ku-mpa.s kanye no-K yi-viscometer engaguquki.
D ukuminyana ekushiseni okungaguquki futhi u-T yisikhathi ukusuka phezulu kuye phansi ngokusebenzisa i-viscometer ngemizuzwana.Le ndlela yokusebenza inzima kakhulu, uma kunento engancibiliki.
Amagama kulula ukubangela amaphutha, kunzima ukubona ikhwalithi ye-hydroxypropyl methyl cellulose.Manje isetshenziswa kakhulu ukukala i-viscosity ye-rotary viscometer, ukusetshenziswa okuvamile e-China.
Ifomula ye-viscometer ye-NDJ-1 ithi η=Kα.η yi-viscosity, futhi ku-mpa.s, K iyi-coefficient ye-viscometer, futhi u-α ukufundwa kwe-viscometer pointer.
IHydroxypropyl methyl cellulose 2% indlela yokuhlola i-viscosity:
1, le ndlela ilungele ukunqunywa kwe-viscosity eguquguqukayo ye-non-Newtonian fluids (isixazululo se-polymer, ukumiswa, i-emulsion dispersion liquid noma isixazululo se-surfactant, njll.).
2. Izinsimbi nezinto zikagesi
2.1 I-Rotary viscometer (i-NdJ-1 ne-NDJ-4 idingwa yi-Chinese Pharmacopoeia)
2.2 Amazinga okushisa avamile okugeza amanzi okugeza okuhlala njalo kwezinga lokushisa elingu-0.10C
2.3 Idigri yokulinganisa izinga lokushisa ngu-0.20C, eqinisekiswa ngezikhathi ezithile.
2.4 Imitha yefrikhwensi Ama-Viscometers asebenzisa izindlela zokuzinzisa imvamisa (njenge-NDJ-1 ne-NDJ-4) azogodlwa.Ukunemba okungu-1%.A
8. Isampula ye-Og yakalwa ngokunembile futhi yafakwa ebhekhani elomile, elinethoni elingu-400mL ubude.Faka cishe u-100mL wamanzi ashisayo angama-80-90 degree bese ugoqa imizuzu eyi-10 ukuze uhlukanise.
Hlakaza ngokulinganayo, gudluza bese wengeza amanzi abandayo ku-400mL esewonke.Khonamanjalo, gudluza ngokuqhubekayo imizuzu engama-30 ukwenza isixazululo esingu-2% (W/W), bese usifaka esiqandisini ukuze ukugeza kweqhwa kuphole kuze kube yilapho kwakheka iqhwa elincanyana phezulu.
Khipha bese ufaka ethangini lokushisa elingashintshi ukuze ugcine izinga lokushisa eliphakathi libe ku-20 ℃ 0.1 ℃.
3.1 Ukufakwa nokusebenza kwensimbi kuzokwenziwa ngokuhambisana nemiyalelo yokusebenza kwethuluzi, futhi i-rotor ne-rotor efanele izokhethwa ngokuya ngebanga le-viscosity lomkhiqizo ohloliwe kanye nezinhlinzeko ze-pharmacopoeia ngaphansi kombhalo we umkhiqizo
Isivinini sokujikeleza.
3.2 Lungisa izinga lokushisa lamanzi elingaguquki ngokuya ngokunquma ngaphansi kwento ngayinye yomuthi.
3.3 Umkhiqizo wokuhlola wafakwa esitsheni esishiwo ithuluzi, futhi i-engeli yokuchezuka (a) ikalwa ngokomthetho ngemva kwemizuzu engama-30 yokushisa okungashintshi.Vala injini bese uyiqalisa kabusha ukuze uzimisele futhi
Umehluko phakathi kwamanani amaphakathi akufanele weqe u-3%, ngaphandle kwalokho kufanele kwenziwe isilinganiso sesithathu.
3.4 Bala inani elimaphakathi lokuhlola okubili ngokwefomula ukuze uthole i-viscosity eguquguqukayo yomkhiqizo ohloliwe.
4. Rekhoda futhi ubale
4.1 Rekhoda imodeli ye-viscometer ejikelezayo, inombolo ye-rotor nesivinini esisetshenzisiwe, i-viscometer engaguquki (inani lika-K), izinga lokushisa elilinganisiwe, nesilinganiso ngasinye.Inani.
Ifomula yokubala engu-4.2
I-Dynamic viscosity (MPa”s)=Ka lapho u-K eyi-viscometer engaguquki elinganiswa ngoketshezi olujwayelekile lwe-viscosity eyaziwayo kanye no-A i-Engeli yokuchezuka
Isikhathi sokuthumela: May-18-2022