Yiziphi izinto ezisuselwa ekutheni zilungele ukukhiqizwa kwamaphilisi alukhuni aluhlaza?

Emlandweni wakudala we-caplule, uGelatin ubelokhu egcina isikhundla sawo njengezinto ezijwayelekile ze-capsule ngenxa yohlobo lwazo olubanzi lwemithombo, ezinzile zomzimba kanye namakhemikhali, kanye nokusebenza okuhle kakhulu. Ngokunyuka okuthandwa ngabantu ngamaphilisi, amakhandlela azenzile asetshenziswa kabanzi emikhakheni yokudla, umuthi kanye nemikhiqizo yokunakekelwa kwempilo.

Kodwa-ke, ukuvela kanye nokusabalala kwesifo senkomo ehlanyayo nesifo sonyawo kanye nomlomo kuphakamise ukukhathazeka ngemikhiqizo ethathwe izilwane. Izinto zokusetshenziswa ezisetshenziswa kakhulu ze-gelatin ziyizinkomo kanye nezikhumba zezingulube nezikhumba, futhi izingozi zalo zihehe kancane ukunaka kwabantu. Ukuze sinciphise ubungozi bokuphepha kwezinto zokwakha ezingenalutho, ochwepheshe embonini bayaqhubeka nokucwaninga nokuthuthukisa izinto zokwakha izitshalo ezifanelekile.

Ngaphezu kwalokho, njengoba izinhlobonhlobo zama-caplule akhuphuka, ukwehlukahlukana kokuqukethwe kwawo kancane kwenza abantu babone ukuthi amaphilisi we-gelatin aze anezinkinga zokuhambisana nezakhiwo ezikhethekile. Isibonelo, okuqukethwe okuqukethe amaqembu ama-Aldehyde noma aphendule amaqembu e-Aldehyde ngaphansi kwezimo ezithile kungaholela ekuxhumaneni ne-gelatin; ukunciphisa okuqukethwe okunciphisa kakhulu kungase kwenziwe ukusabela kwe-maillard (ukusabela kwe-imeyiliid) ngokuphendula kwe-gelatin); Okuqukethwe kwe-hygroscopic kuzodala igobolondo le-gelatin capsule ukuze lilahle amanzi futhi lilahlekelwe ubulukhuni bayo bokuqala. Izinkinga zokuqina ezichazwe ngenhla ze-gelatin eziyize capsule zidonsele ukunakwa okwengeziwe ekuthuthukisweni kwezinto ezintsha ze-capsule.

Imizamo eminingi yenziwe. Inombolo yesicelo se-Chinese Patent Searture 200810061238.3 ifakwe ukusetshenziswa kwe-sodium cellulose sulfate njengezinto eziphambili ze-capsule; 200510013285.3 Kufakwe isicelo sokusetshenziswa kwesitashi noma isitashi sokwakheka kwesitashi njengezinto eziphambili ze-capsule; Wang gm [1] Kubikwe ukukhiqizwa kwe-chitosan capsule izinto zokwenziwa kwezindwangu eziyize; I-Xiaojuju Zhang et al [2] ibike ukuthi amaprotheni we-konjac-soybean angokwezinto eziphambili ze-capsule. Vele, abafundwa kakhulu yizinto zokwakha amaselula. Phakathi kwazo, ama-caplule azenzile enziwe nge-hydroxypropylylylylylylylylylylylylylylylylylylylyllose (HPMC) akhiqizwa ngobuningi.

I-HPMC isetshenziswa kabanzi emkhakheni wokudla nomuthi, futhi iyisivumelwano esivame ukusetshenziswa kwekhemisi, esilotshwe e-pharmacopoeis yamazwe ahlukahlukene; I-FDA ne-European Union ivume i-HPMC njengesengezo sokudla esiqondile noma esingaqondile; I-GRAS iqoshwa njengento ephephile, Cha. GRN 000213; kufakwe database we-jecfa, ins No.464, akukhawuleli umthamo omkhulu wansuku zonke we-HPMC; Ngo-1997, uMnyango Wezempilo waseChina wakuvumela njengesengezo sokudla kanye nesikhulu (No. 20), elungele zonke izinhlobo zokudla, ngokuya ngokukhiqiza kudingeka ukwengeza [2-9]. Ngenxa yomehluko kwizakhiwo ezine-gelatin, ukunikezwa kwe-HPMC okungekho emthethweni kuyinkimbinkimbi ngokwengeziwe, futhi amanye ama-gelling ads adinga ukungezwa, njenge-acacia, i-carrageenan (njll.

I-HPMC Hoze Capsule ingumkhiqizo onomqondo wemvelo. Inqubo yayo yokukhiqiza neyokukhiqiza ibonwa ubuJuda, amaSulumane kanye nezinhlangano zemifino. Ingahlangabezana nezidingo zabantu abanezinkolo ezahlukahlukene kanye nemikhuba yokudla, futhi inokwamukelwa kwezinga eliphakeme. Ngaphezu kwalokho, ama-HPMC azwakala ama-caplule nawo anezakhiwo ezikhethekile ezilandelayo:

Okuqukethwe kwamanzi okuphansi - cishe ama-60% aphansi kune-gelatin angenalutho caplules

Okuqukethwe kwamanzi kwama-gelatin aze caplule ngokuvamile ayi-12.5% ​​-17.5%. Izinga lokushisa kanye nomswakama wemvelo kufanele lilawulwe ngaphakathi kobubanzi obufanele ngesikhathi sokukhiqiza, izinto zokuhamba, ukusetshenziswa kanye nokugcinwa kwamaphilisi angenalutho. Izinga lokushisa elifanelekile ngu-15-25 ° C kanti umswakama ohlobene ngu-35% -65%, ukuze ukusebenza komkhiqizo kugcinwe isikhathi eside. Okuqukethwe kwamanzi kwefilimu le-HPMC kuphansi kakhulu, ngokuvamile ama-4% -5%, acishe abe ngu-60% aphansi kunalewa amaphilisi we-gelatin azuzisayo. Ukushintshaniswa kwamanzi nemvelo ngesikhathi sokugcina isikhathi eside kuzokwengeza okuqukethwe kwamanzi kwama-HPMC angenalutho amakhompiyutha kuphakheji obekiwe, kepha ngeke kwedlule 9% kungakapheli iminyaka emi-5.