Iliphi inani le-PH le-HPMC?

Ivelu ye-PHC (Hydroxypropyl Methylcellulose) incike ekuhlushwa kwayo kusixazululo, izinga lokushisa kanye nekhwalithi kanye nobumsulwa bamanzi asetshenzisiwe. Imvamisa, inani le-PH ye-HPMC kwisixazululo samanzi liphakathi kuka-5.0 no-8.0, ngokuya ngezimo zokuqothula kanye nemininingwane enikezwe ngumenzi.

1. Izici eziyisisekelo ze-HPMC
I-HPMC iyinhlangano yokususelwa e-Ion-ionic cellulose esetshenziswa kakhulu kwizimboni zezemithi, zokudla kanye nezimonyo, ngokuqina okuhle, ukuqina nokuqina. Akukona-ionic, kuncibilike emanzini abandayo kepha hhayi emanzini ashisayo, futhi isixazululo ngokuvamile asithathi hlangothi noma sinama-acidic kancane. Ezihlotsheni zezimboni, i-HPMC yamukelwa kabanzi ngempumelelo yokuphepha kwayo kanye nezinto ezizinzile.

2. Uhla lwe-PH lwekhambi lamanzi le-HPMC
Ngokwemininingwane yelebhu kanye nocwaningo lwezincwadi, inani le-PHC elinezixazululo eziphansi zamanzi eziphansi (ezifana ne-1-2%) ngokuvamile ziphakathi kuka-5.0 no-8.0. Imiyalo yomkhiqizo enikezwe ngumenzi ngokuvamile inikeza uhla olufanayo lwe-PH ukuze abasebenzisi babheke kwinqubo yokucushwa. Isibonelo, inani le-PH yemikhiqizo ethile ye-HPMC kwisisombululo esingamanzi esingu-0,1% cishe singama-5.5 kuye ku-7.5, asondele kakhulu ekungathathi hlangothi.

Isixazululo esiphansi sokuhlushwa: ekuhluphisweni okuphansi (<2%), inani le-PH le-HPMC ngemuva kokuncibilika emanzini ngokuvamile asondelene nokungathathi hlangothi.

Isixazululo esiphezulu sokuhlushwa: Ekugxileni okuphezulu, i-viscosity yesixazululo iyanda, kepha ivelu ye-PH isashintshashintsha ekwakhiweni eduze kokungathathi hlangothi.

Umphumela wokushisa: I-solubity ye-HPMC ithintwe kakhulu izinga lokushisa. Kuyancibilika kalula emanzini abandayo futhi kuthambekele kalula emanzini aphezulu okushisa. Lapho ulungiselela ikhambi le-HPMC, kuvame ukunconyelwa ukusebenzisa amanzi abandayo ukugwema izinguquko ze-solubity ezibangelwa ukushisa okuphezulu ngokweqile.

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Imvamisa, ngesikhathi sokukhiqiza nokusebenzisa, lapho uthola inani le-PH yekhambi lamanzi le-HPMC, kusetshenziswe imitha ye-PH ye-CALIBCE Kodwa-ke, lezi zinto ezilandelayo zingathinta imiphumela yokulinganisa:

Ukuhlanzeka kwamanzi: Amanzi avela emithonjeni ehlukene angaqukatha usawoti oncibilikisiwe, amaminerali, njll., Okuthinta imiphumela yokulinganisa i-PH. Ngokuvamile kunconyelwa ukusebenzisa amanzi a-deionized noma amanzi afakwe emanzini ukulungiselela isisombululo se-HPMC ukuqinisekisa ukunemba kwemiphumela.
Ukuhlushwa Isixazululo: Ukuhlushwa kwe-HPMC, kukhuphuka okukhulu kwekhambi, okuletha ubunzima bokulinganisa kwe-PH, ngakho-ke izixazululo eziphansi (<2%) zisetshenziswa ngokuvamile.
Imvelo yangaphandle: izinga lokushisa, ukulinganiswa kwamathuluzi wokulinganisa, njll. Kungadala ukuphambuka kwe-PH okuncane.

4. Izidingo zakwa-PH kwizimo zesicelo se-HPMC
Lapho i-HPMC isetshenziswa ekudleni nasezokwelapha, ukuqina kwayo nokuguquguquka kwayo kudingeka kubhekwe. Isibonelo, kumathebulethi wezemithi namalungiselelo e-capsule, i-HPMC isetshenziswa njenge-persener, i-ejenti yokukhishwa kwezimali kanye nokuqina kwe-coating, kanye nokuqina kwe-pH kuyinto ebalulekile. Izidakamizwa eziningi zidinga ukukhishwa endaweni esondelene nengathathi hlangothi noma kancane acidic, ngakho-ke izici ze-PH ze-HPMC zilungele kakhulu le nhloso.

Imboni yokudla: Lapho i-HPMC isetshenziswa njengesikhudlwana nesikhuthalo, kuvame ukuthembela ukuthi inani layo le-PH liseduze nokungathathi hlangothi ukuze lithinte ukunambitheka nokuqina komkhiqizo.
Imboni yezemithi: Kumathebulethi kanye nama-caplule, i-HPMC isetshenziselwa ukulawula ukukhishwa kwezidakamizwa, futhi i-PH ezinzile eduzane nokungathathi hlangothi kusiza ukugcina umuthi.

I-5. Indlela yokulungisa ye-PH yekhambi lamanzi le-HPMC
Uma inani le-PH lesisombululo se-HPMC lidinga ukuguqulwa kuhlelo lokusebenza oluthile, lungahle luhlelwe kahle ngokungeza i-acid noma i-alkali. Isibonelo, inani elincane le-Dilute hydrochloric acid noma i-sodium hydroxide solution lingasetshenziswa, kepha kufanele lilawulwe ngokucophelela ukuze ligweme ukwedlula uhla lwezokuphepha noma oluthinta ukuqina kwe-HPMC.

Inani le-PH le-HPMC kwisixazululo se-aqued ngokuvamile liphakathi kuka-5.0 no-8.0, eliseduze nokungathathi hlangothi. Izidingo ze-PH zezindawo ezihlukile zohlelo zingahluka kancane, kepha imvamisa azikho ukulungiswa okukhethekile okudingekayo.