Yikuphi ukubonakala okufanelekile kwe-hydroxypropyllyllose methylcellulose?

I-Hydroxypropyl Methylcellulose (HPMC) iyisigcini esivame ukusetshenziswa kwamanzi esisetshenziswa emanzini, izimonyo, ukudla nokwakha. I-HPMC inemisebenzi yokulawula ukubonakala, izilonge ama-emulsions, ngcono izakhiwo ze-mboho kanye nokuqina, ngakho-ke i-viscosity iyipharamitha esemqoka ekusetshenzisweni kwayo.

1. Izici ze-Viscosity ze-HPMC
I-viscosity ye-HPMC ihlobene kakhulu nesisindo sayo samangqamuzana, izinga lokufaka esikhundleni (ie, izinga lokufakwa esikhundleni se-hydroxypropyll kanye namaqembu we-methyl), ukugxila kwesixazululo nakwezinye izinto. Ngokuvamile, ubukhulu besisindo se-molecular, ukukhuphuka kwendlela yekhambi le-HPMC. Ngaphezu kwalokho, izixazululo ze-HPMC ezinesilinganiso esiphakeme sokufaka esikhundleni sezinto eziphakemeyo ngoba izinga lokufaka esikhundleni sokufaka lithinta ukwakheka kwe-chain yamangqamuzana, okuthinta ukusebenza kwayo nokusebenza kwensizwa.

I-viscosity ye-HPMC imvamisa ilinganiswa ngesilinganiso esithile se-shear usebenzisa i-vesili elijikelezayo. Ngokuya ngohlelo lokusebenza lwe-HPMC, inani elidingekayo lesevo lehlukile lihlukile.

2. Izidingo ze-HPMC Viscosity ezihlelweni ezihlukile
Insimu Yezemithi
Embonini yezemithi, i-HPMC ivame ukusetshenziselwa ukupheka amaphilisi, amaphilisi, amaconsi wamehlo nezidakamizwa ezilawulwa ezilawulwayo. Ukulungiselela amaphilisi nama-capsule, i-HPMC idlala indima ebalulekile ekulingweni kokukhululwa kwezidakamizwa njengefilimu yangaphambili nefilimu.

Amalungiselelo wokukhishwa alawulwayo: Amalungiselelo okukhishwa kwezidakamizwa alawulwayo adinga i-HPMC ibe nokubonakala okulinganiselayo. Ngokuvamile, ukubonakala kwesisombululo se-HPMC kufanele kulawulwe phakathi kwama-300 no-2000 mpla, okusiza ukukhishwa okuqinile nokulawulwa komuthi. Uma i-viscosity iphakeme kakhulu, umuthi ungadedelwa kancane; Lapho i-viscosity iphansi kakhulu, umphumela wokukhishwa kwezidakamizwa ungazinzile.

Ukucindezelwa Kwethebhulethi: Ngesikhathi senqubo yokucindezela kwethebhulethi, i-viscosity ye-HPMC inethonya elibalulekile ekusebenzeni kwethebhulethi nokuqhekeka kwesikhathi. Ngalesi sikhathi, i-visa kufanele ibe phakathi kuka-500 no-1500 amalungu e-MPA ukuqinisekisa ukunamathela okuhle nokusebenza kahle kokuqhekeka.

Insimu yokudla
Embonini yokudla, i-HPMC ivame ukusetshenziswa njengesikhulu kanye ne-emulsifier emikhiqizweni efana nemikhiqizo, u-ayisikhilimu kanye neziphuzo zezithelo zezithelo. Imikhiqizo ehlukene inezidingo ezihlukile zokuvulelwa kwe-HPMC:

Iziphuzo zejusi yezithelo: Ezithelweni zejusi yezithelo, ukubonwa kwe-HPMC kufanele kulawulwe phakathi kwama-mpa we-50 no-300. Ukubonakala okuphezulu kakhulu kungadala ukuthi isiphuzo sinambithe kakhulu, esingavumeli ukwamukelwa kwabathengi.

I-Ice Cream: ye-Ice Cream, i-HPMC isetshenziselwa ukuthuthukisa ukuthungwa kwayo nokubusheleleka. Ngalesi sikhathi, inani le-viscosity livame ukulawulwa phakathi kuka-150 no-1000 MPA SOKUQALA ukuqinisekisa ukuthi u-ayisikhilimu unokunye ukuguquguquka okufanele futhi uzizwe.

Inkambu yokwakha
Embonini yezokwakha, i-HPMC ivame ukusetshenziswa ezintweni zokwakha ezifana nesimende, i-gypsum nodaka. Iqhaza le-HPMC kulezi zinto zokwakha ikakhulukazi ukuqina futhi lithuthukise uketshezi. Uhla lwayo lokubonakayo luvame ukubanzi, imvamisa 2000 kuya ku-10000 Mpa. I-HPMC kuleli banga ithuthukisa ngempumelelo ukusebenza kokwakha kwezinto zokwakha, njengokuthuthukisa ukusebenza nokunweba isikhathi sokuvula.

Inkambu yezimonyo
Ensimini yezimonyo, i-HPMC ivame ukusetshenziselwa ukwakhiwa kwemikhiqizo efana nama-lotion, ama-emulsishini, ikakhulukazi ukudlala indima ye-HPMC ngokuvamile okudingeka ibe mnene, cishe ama-1000 kuya ku-3000 MPA S. Ukubona okuphezulu kakhulu kungadala ukusetshenziswa okungalingani komkhiqizo, okuthinta isipiliyoni somsebenzisi.

3. Izici ezithinta ukubonakala kwe-HPMC
Isisindo samangqamuzana: Kukhudlwana isisindo se-molecular ye-HPMC, isikhathi eside i-acat molecular, kanye nokuphakama kwendlela yekhambi. Ku-HPMC ngesisindo esikhulu samangqamuzana, ukubonakala kwesixazululo saso ekuhlushweni okufanayo kuzoba ngaphezulu kakhulu kunalokho kwe-HPMC ngesisindo esiphansi samangqamuzana. Ngakho-ke, ukukhetha i-HPMC ngesisindo se-molecular esifanele kuyisihluthulelo sokulawula ukubonwa.

I-degree yokufaka esikhundleni: izinga lokufaka esikhundleni se-HPMC, okungukuthi, izinga lokufaka esikhundleni se-hydroxypropyl kanye ne-methyl, lizothinta ukubonakala kwalo. Izinga eliphakeme lokufaka esikhundleni senza ama-molecule we-HPMC azinze ngokwengeziwe, futhi ukuxhumana phakathi kwama-molecule kuyanda, okuholela ekuboniseni ukuhlakanipha.

Ukuhlushwa Isixazululo: Ukuhlushwa kwekhambi le-HPMC kunethonya elikhulu ekubonakaleni. Ngokugxila okuphansi, ukubonakala kwesisombululo se-HPMC kuphansi; Ngokugxila okuphezulu, ukuxhumana phakathi kwamaketanga ama-molecular kuyathuthukiswa, futhi i-viscosity inyusa kakhulu. Ngakho-ke, kuzinhlelo zokusebenza ezisebenzayo, i-viscosity yomkhiqizo wokugcina ingalawulwa ngokulungisa ukugcwala kwe-HPMC.

I-Solvents kanye nezimo zemvelo I-solvents ehlukene kanye nezinga lokushisa elihlukile nemibandela ye-PH izoshintsha i-solubity ye-HPMC, ngaleyo ndlela kuthinte ukubonwa kwesixazululo saso.

I-viscosity ye-HPMC ingenye yamapharamitha abalulekile ekusetshenzisweni kwayo emikhakheni ehlukahlukene. Emikhakheni, ukudla, ukwakha, izimonyo kanye nezinye izimboni, ukubonakala kwe-HPMC kufanele kulawulwe ngaphakathi kwebanga elithile ngokuya ngezidingo ezahlukahlukene zomkhiqizo. Ngokulungisa izinto ezifana nesisindo samangqamuzana, izinga lokufaka esikhundleni, okuhlushwa kanye ne-solvent ye-HPMC, i-viscosity yayo ingalawulwa ngokunembile ukuze ihlangabezane nezidingo zezinhlelo zokusebenza ezihlukile. Enqubweni yokukhiqiza yangempela, ukwenza kahle ukubonakala kwezidingo ezithile zesicelo kuyisihluthulelo sokuqinisekisa ikhwalithi yomkhiqizo nokusebenza.