Yiliphi izinga lokushisa le-gel le-hydroxypropyllyllose methylcellulose?

Ukushisa kwe-gel kwe-hydroxypropyllllylyll (hpmc) yipharamitha ebalulekile emikhakheni ehlukahlukene, kufaka phakathi amakhambi, ukudla, izimonyo kanye nokwakha. I-HPMC iyi-polymer ye-semi-zokwenziwa ethathwe ku-cellulose, esetshenziswe kabanzi njengomuntu omkhulu, i-tinder, kanye ne-stabilizer kuhlelo lokusebenza oluningi ngenxa yokusebenzisana kwayo, okungelona ubuthi, kanye nezakhiwo ezenziwe ngefilimu.

Ukuqonda izinga lokushisa le-gel le-HPMC kubalulekile ngoba lithonya ukubonakala kwalo, ukulekelela, nokuziphatha kwe-gelation, okuthinta umsebenzi wokushisa kwe-gel okusetshenzisiwe.

Kuyini izinga lokushisa le-gel?
Ukushisa kwe-gel kwe-polymer kubhekisele emazingeni okushisa lapho kwakha khona ijeli ku-hydration noma ukuqondiswa kwe-solvent. Ku-HPMC, lokhu kungamazinga okushisa lapho i-polymer chains ingena futhi yakha inethiwekhi enezici ezintathu, okuholela ekuthini kwe-gel. Lokhu kuguqulwa kusuka kusisombululo se-Gel State kubalulekile ekusebenzeni kwayo kuzicelo ezahlukahlukene.

Izici ezithinta izinga lokushisa le-gel le-HPMC:
I-degree yokufaka esikhundleni (DS): Ukushisa kwe-gel ye-HPMC kuya ngezinga lokufaka esikhundleni se-hydroxyproppropyl kanye namaqembu we-methyl. Ngokuvamile, i-DS ephakeme iholela emazingeni okushisa aphansi we-gela.

Isisindo se-molecular (MW): Isisindo esiphakeme se-molecular HPMC sivame ukuba namazinga okushisa aphezulu we-gel ngenxa yokukhuphuka kwe-chain entanglement.

Ukuhlushwa kanye ne-solvent: Ukushisa kwe-gel kuthonywa ukugxilwa kwe-HPMC kanye nohlobo lwe-solvent. Ukugxila okuphezulu kanye ne-solvents ethile kunganciphisa izinga lokushisa le-gel.

Izengezo: Isengezo sosawoti, ama-acid, noma amanye ama-polymers angaguqula ukusebenza kwe-gelation ye-HPMC.

I-PH: PH ithinta i-Ionization yamaqembu asebenzayo ku-HPMC, okuthitha amathonya ngokuziphatha kwayo kwe-gelation.

Ukunqunywa kokushisa kwe-gel:
Izindlela eziningana ziqashwa ukunquma izinga lokushisa le-gel le-HPMC:

Ukubukwa okubukwayo: Ukuqapha isisombululo ngokubona izinguquko ekuboneni noma i-turbidity njengoba izinga lokushisa lishintsha.

Izilinganiso ze-Rheological: Sebenzisa ama-rheometers ukukala izinguquko ku-viscosity noma i-elastic modulus njengomsebenzi wokushisa.

Ukuhlukaniswa kwe-Clorimetry (DSC): Ukuthola i-Endothermic Peak ehambelana ne-gel ukwakheka.

I-Turbidimetry: Ukuqapha ukuvela kwesixazululo kusetshenziswa amasu wokuhambisa akhanyayo.

Ukubaluleka Emigodini:
Ama-Pharmaceuticals: Kuzinhlelo zokulethwa kwezidakamizwa, izinga lokushisa le-gel lama-hpmc asuselwa ku-HPMC linquma ama-kinetics okukhishwa kwezidakamizwa kanye namandla e-gel, enomthelela efeckacy nokuqina kokwenziwa kwemithi.

Imboni yokudla: I-HPMC isetshenziswa njengesikhulu, i-stabilizer, kanye ne-ejenti ye-gelling emikhiqizweni yokudla. Ukushisa kwe-gel kuthinta ukuthungwa, umlomo, nokuqina kokudla kokudla.

Izimonyo: Ukushisa kwe-gel kuthonya izakhiwo zesimbozo sokwenziwa kwezimonyo, ukusakazeka komkhiqizo, ukuqina kanye nezimpawu zokuzwa.

Ukwakha: Ezintweni zokwakha ezinjengezidakamizwa ezifana nodaka kanye nokunamathela, izinga lokushisa le-gel's gel lithinta ukusebenzela, ukubeka isikhathi namandla okugcina komkhiqizo.

Ukushisa kwe-gel kwe-hydroxypropylllylylylylylylyllose kudlala indima ebaluleke kakhulu ekusebenzeni kwayo kuyo yonke imboni ehlukahlukene. Ukuqonda izici ezinethonya lokuthonya kanye nokusebenzisa amasu afanelekayo okulinganisa kubalulekile ekwakheni ukwakhiwa komkhiqizo kanye nokuqinisekisa izakhiwo ezifiselekayo. Njengoba izimboni ziyaqhubeka nokusungula, ukukhohlisa kwamazinga okushisa we-gel's we-HPMC kuzohlala kuyindawo yocwaningo nokuthuthuka okusebenzayo, ukushayela ukuthuthuka okuhlukahlukene kwezicelo.