Uyini umehluko phakathi kwe-HPMC ne-MC kwizicelo zemithi?

I-Hydroxypropyl Methylcellulose (HPMC) ne-methylcellulose (MC) zombili izinto ezisetshenziselwa izinhlelo zokusebenza ezisetshenziswa kabanzi kwizicelo zemithi ngenxa yezindawo zazo eziguquguqukayo ngenxa yezakhiwo zazo eziguquguqukayo ngenxa yezindawo zazo eziguquguqukayo. Naphezu kokufana kwabo, banomehluko ohlukile ekwakhiweni kwamakhemikhali, izakhiwo, kanye nezicelo ezibenza zilungele izinhloso ezahlukahlukene embonini yezemithi.

Ukwakheka kwamakhemikhali nesakhiwo
I-Hydroxypropyl methylcellulose (HPMC):

I-HPMC iyi-ether eguqulwe ngamakhemikhali. Kususelwa ku-cellulose ngokuyiphatha nge-methyl chloride ne-propelene oxide, eyethula ama-methoxy (-Ch2chohchch3) amaqembu (-Ch2chohchch3) e-cellulose backbone. Izinga lokufaka esikhundleni (DS) kanye ne-molar actiation (MS) ukunquma isilinganiso salawa maqembu. I-DS imele inani eliphakathi lamaqembu ama-hydroxyl afakwe esikhundleni seyunithi ngayinye ye-anhydroglucose, ngenkathi ama-MS akhombisa inani eliphakathi lamaqembu ama-hydroxypropylyl anamathiselwe.

Methylcellulose (MC):

I-MC ingenye i-ether ye-cellulose, kepha ayiguqulwanga kancane uma iqhathaniswa ne-HPMC. Kukhiqizwa ngokwelapha iselula nge-methyl chloride, okuholela ekufumbeni kwamaqembu ama-hydroxy namaqembu we-methoxy. Lokhu kuguqulwa kulinganiswa ngezinga lokufakwa esikhundleni (DS), okuyinto, ye-MC, amabanga avela ku-1,3 kuye ku-2.6. Ukungabikho kwamaqembu ama-hydroxypropyl ku-MC akuhlukanise ku-HPMC.

Izakhiwo Ezibonakalayo
I-Solubity ne-gelation:

I-HPMC iyanyibilika kuwo womabili amanzi abandayo nawashisayo, akha isixazululo se-colloidal. Lapho ushisa, i-HPMC ibhekana ne-germoreversible gelalation, okusho ukuthi kwakha ijeli lapho kufudunyezwa futhi kubuyela kwikhambi lapho kupholisa. Le mpahla iwusizo ikakhulukazi ekukhishweni kwezidakamizwa ezilawulwayo futhi njengesibambiso se-viscosity ezixazululweni zamanzi.

Ngakolunye uhlangothi, i-MC, incanela emanzini abandayo kepha insoluble emanzini ashisayo. Kukhombisa futhi i-thermogelation; Kodwa-ke, izinga lokushisa layo le-gelation livame ukwedlula lelo le-HPMC. Lesi sici senza i-MC ilungele izinhlelo zokusebenza ezikhethekile zemithi lapho izinga lokushisa eliphansi le-gelation linenzuzo.

I-Viscosity:

Kokubili i-HPMC ne-MC kungakhulisa kakhulu ukubonwa kwezixazululo zamanzi, kepha i-HPMC ivame ukunikeza uhla olubanzi lwe-viscosities ngenxa yamaphethini alo ahlukahlukene ahlukahlukene. Lokhu kuhluka kuvumela ukulawulwa okuqondile ngokwengeziwe ekuqanjweni okudinga amaphrofayli athile okususelwa.

Ukusebenza kuma-Pharmaceuticals
I-HPMC:

Ukukhishwa kwe-Matrix okulawulwayo:
I-HPMC isetshenziswa kabanzi ekuhlinzekweni kwama-matrix okulawulwa. Amandla awo okuvuvukala futhi akha ungqimba lwejeli lapho uthintana nolwelashisi esiswini lusiza ukulawula isilinganiso sokukhishwa kwezidakamizwa. Isendlalelo sejeli sisebenza njengesithiyo, siguqula ukuxhashazwa kwesidakamizwa nokwelula ukukhishwa kwaso.

I-Film coating:
Ngenxa yezakhiwo zayo ezinhle kakhulu zefilimu, i-HPMC isetshenziswa kabanzi ekuhlanganisweni kwamathebulethi kanye nama-pellets. Inika isithiyo esivikelayo ngokumelene nomswakama, umoya-mpilo, nokukhanya, okuthuthukisa ukuqina kanye nempilo yeshelufu yomkhiqizo. Ngokwengeziwe, izimbobo ze-HPMC zingasetshenziselwa ukunambitheka masking kanye nokwenza ngcono ukubukeka kwamathebulethi.

I-Binder ekusungulweni kwethebhulethi:
I-HPMC nayo iqashwa njenge-binder in izinqubo ze-granution ezimanzi. Iqinisekisa amandla wemishini yamathebulethi, okwenza ukubopha izinhlayiya ze-powder ngesikhathi sokucindezela.

Umemeze wokumisa nokuqina:
Emakwakheni uketshezi, i-HPMC isebenza njenge-ejenti yokumisa nokuqina. I-viscosity yayo ephezulu iyasiza ekugcineni ukuhanjiswa komfaniswano wezinhlayiya ezimisiwe futhi kuthuthukise ukuvumelana kokwakhiwa.

MC:

I-Tablet Binding:
I-MC isetshenziswa njenge-binder ekusungulweni kwethebhulethi. Inikeza izakhiwo ezinhle zokubopha namandla emishini kumathebulethi, kuqinisekisa ubuqotho babo ngesikhathi sokuphatha nokugcina.

Ukuqhekeka:
Kwezinye izimo, i-MC ingasebenza njengokuqhekeka, isiza amaphilisi ukuze ahlukanise izingcezwana ezincane lapho axhumana noketshezi lwesisu, ngaleyo ndlela anikeze ukukhishwa kwezidakamizwa.

Izakhiso Zokukhishwa Ezilawulwayo:
Yize kuncane kakhulu kune-HPMC, i-MC ingasetjenziswa ekwakhiweni kokukhishwa okulawulwayo. Izakhiwo zalo ze-thermogelalation zingaxhashazwa ukulawula iphrofayili yokukhishwa kwezidakamizwa.

Ukuqina nokuqina kwe-ejenti:
I-MC isetshenziswa njenge-ejenti yokuqina kanye nokuzinza kokuma kwendlela ehlukahlukene eqinile neyama-semi-aqinile. Amandla awo okukhulisa i-viscosity asiza ekugcinweni kokuqina kanye ne-homogeneity yomkhiqizo.

Izicelo ezithile ku-Pharmaceuticals
Izicelo ze-HPMC:

Amalungiselelo we-Ophthalmic:
I-HPMC isetshenziswa kaningi kuzixazululo ze-ophthalmic kanye nama-gels ngenxa yezakhiwo zayo zokugcoba kanye ne-viscoelastic. Inika ukugcinwa komswakama futhi idlule isikhathi sokuxhumana sesidakamizwa nge-ocular ebusweni.

Izinhlelo zokulethwa kwezidingo:
I-HPMC iqashwa kwiTransdermal Patches lapho amandla ayo akha amafilimu asiza ekwakheni i-matrix elawulwayo yokukhishwa kwezidakamizwa ngokulethwa kwezidakamizwa.

Izakhiwo ze-mucoadhesive:
Izakhiwo ze-mucMheseve ze-HPMC zenza zilungele izinhlelo ze-buccal, ze-nasal, kanye nama-vaginal devil devitory zokulethwa kwezidakamizwa, kuthuthukisa isikhathi sokuhlala sokwakhiwa endaweni yesicelo.

Izicelo ze-MC:

Izakhi ze-Topical:
I-MC isetshenziswa kumakhilimu we-topical, ama-gels, kanye namafutha lapho isebenza khona njenge-ejenti yokuqina nokuzinza, ngcono ukusakazeka kanye nokuvumelana komkhiqizo.

Ukudla nokudla okunempilo:
Ngaphandle kwemithi yezemithi, i-MC ithola izinhlelo zokusebenza emikhiqizweni yokudla kanye nenzuzo njenge-swerener, i-emulsifier, ne-stabilizer, nomthelela kulolu cwaningo kanye nokuqina kwemikhiqizo ehlukahlukene.

Ngamafuphi, i-HPMC ne-MC zombili ziyizinto ezibalulekile ze-cellulose decivatives ezinezimpawu ezihlukile ezibenza zilungele izinhlelo ezahlukahlukene zezemithi. I-HPMC, nge-soulility yayo eyenziwe kabili ngamanzi ashisayo nebandayo, uhla oluphezulu lobumba, kanye namakhono okwakha amafilimu, kuthandwe ikakhulukazi ukwakheka kokukhishwa okulawulwayo, ukumboza ithebhulethi, kanye namalungiselelo we-ophthalmic. I-MC, ngenkathi elula ekwakhekeni, inikezela ngezinzuzo ezihlukile ku-solubity enamanzi ebandayo kanye namazinga okushisa aphansi we-gelation, okwenza kube lusizo njenge-binder, ukuqhekeka, kanye ne-ejenti yokuqina kwezicelo ezithile. Ukuqonda umehluko ezinhlakeni zabo zamakhemikhali, izakhiwo ezibonakalayo, kanye nokusebenza okuvumela amathimu ukuthi akhethe i-cellulative etholwayo yokuthola izidingo ezithile zemikhiqizo yezemithi.