Ukwahlulela ikhwalithi ye-hydroxypropylylylylylylym methyl cellulose

I-Hydroxypropyl Methyl Cellulose (HPMC) iyinhlangano eguquguqukayo ethola ukusetshenziswa okubanzi emikhakheni ehlukahlukene, okubandakanya amakhambi, ukwakhiwa, ukudla, izimonyo, nokuningi. Izicelo zalo ezahlukahlukene zivela ezingxenyeni zalo ezihlukile, njengamandla akha ifilimu, umthamo wokuqina, izakhiwo ezibophayo, nezici zokugcina amanzi. Izinga le-HPMC libalulekile ekuqinisekiseni ukusebenza kahle nokuphepha kwemikhiqizo esetshenziswa kuyo.

Ukwakheka kwe-1.Chical:
Ukwakheka kwamakhemikhali kwe-HPMC kubalulekile kwikhwalithi yayo. I-HPMC iyinto etholwa yi-cellulose, eguqulwe nge-hydroxypropylition nezinqubo ze-methylation. Izinga lokufaka esikhundleni se-hydroxypropyllopyl kanye namaqembu we-metholy lithonya kakhulu izakhiwo zalo. Amanani aphezulu we-DS ngokuvamile aphumela ekukhulisweni kwamanzi akhuphukile futhi anciphe izinga lokushisa le-gelation. Amasu wokuhlaziya afana ne-pasletic magnetic resonance (NMR) Spectroscopy kanye ne-infrared (IR) i-spectroscopy ivame ukuqashwa ukunquma ukwakheka kwamakhemikhali kanye nama-DS amasampula we-HPMC.

2.Purity:
Ubumsulwa buyisici esibucayi sekhwalithi ye-HPMC. Ukungcola kungathinta ukusebenza nokuqina kwemikhiqizo. Ukungcola okuvamile kufaka phakathi izixazululo ezisele, izinsimbi ezisindayo, kanye nokungcola kwe-microbial. Izindlela ezahlukahlukene zokuhlaziya ezifana ne-chromatography ephezulu ye-chromatography (HPLC), i-chpc chromatography (GC), futhi i-plasma-mass ehlanganisiwe ehlanganisiwe, i-ICP-MS) isetshenziselwa ukuhlola ubumsulwa amasampula we-HPMC.

Isisindo se-3.Moleecular:
Isisindo samangqamuzana se-HPMC sithonya izakhiwo zalo ze-rhelogical, ukulekelela kanye nekhono elenza ifilimu. Isisindo esiphakeme se-molecular HPMC ngokuvamile sibonisa ubuciko obukhulu bokubonakala kanye namandla efilimu. I-gel Pretomonelity Chromatography (GPC) iyindlela esetshenziswa kabanzi yokunquma ukusatshalaliswa kwesisindo kwamangqamuzana amasampula we-HPMC.

I-4.Viscutity:
I-Viscosity iyipharamitha ebalulekile yekhwalithi ye-HPMC, ikakhulukazi kuzinhlelo zokusebenza ezinjengezakhi zemithi, lapho isebenza khona njenge-ejenti yokuqina. I-viscosity yezixazululo ze-HPMC ithintwa yizinto ezifana nokuhlushwa, izinga lokushisa, kanye nezinga le-shear. Izindlela ezahlukahlukene ze-Viscometric, kufaka phakathi ama-viscompetry ajikelezayo kanye nama-viscompetry e-capillary, aqashwa ukukala ukubonwa kwezixazululo ze-HPMC ezimeni ezihlukile.

Okuqukethwe kwe-5.ph kanye nomswakama:
Ukuqukethwe kwe-PH kanye nomswakama ye-HPMC kungathinta ukuqina nokuhambisana kwayo nezinye izithako zokwakheka. Okuqukethwe komswakama kubaluleke kakhulu njengokuma umswakama ngokweqile kungaholela ekukhuleni kwe-microbial kanye nokonakaliswa kwe-HPMC. Ukuqanjwa kwe-Karl Fischer kuvame ukusetshenziselwa ukunquma okuqukethwe umswakama, ngenkathi amamitha we-PH aqashwa ngokulinganisa i-PH.

Usayizi ongu-6.Pirticle ne-morphology:
Ubukhulu bezinhlayiyana ne-morphology badlala indima ebalulekile ekwakheni izakhiwo kanye nokungafani kwamandla we-HPMC. Amasu anjengokwehluka kwe-laser nokuskena i-elektroni microscopy (SEM) asetshenziswa ukuthi abonise ukusatshalaliswa kosayizi wezinhlayiyana kanye ne-morphology yezinhlayiya ze-HPMC.

Izakhiwo ezingama-7.thermal:
Izakhiwo ezishisayo ezinjengokushisa kwe-Glass Transition (TG) kanye nokushisa okuwohloka okushisayo kunikeza ukuqonda ekuzinzileni nasekusetshenzisweni kwezimo ze-HPMC. Ukuhlukaniswa okuhlukile kwe-calorimetry (DSC) kanye nokuhlaziywa kwe-thermogravimetric (TGA) kuvame ukusetshenziswa ukuhlaziya ukuziphatha okushisayo kwamasampula we-HPMC.

I-8.gelation ne-FIELMOTION
Ngezicelo ezidinga ukwakheka kwe-gel noma ukwakheka kwamafilimu, izinga lokushisa le-gelation kanye nezakhiwo ezenziwe ngefilimu ze-HPMC zingamapharamitha asemqoka. Izilinganiso ze-Rheological kanye nokuhlolwa okwakha amafilimu kwenziwa ukuze kuhlolwe lezi zinto ngaphansi kwezimo ezifanele.

Ukuhlola ikhwalithi ye-hydroxypropyllylylylylylylyllop (HPMC) kubandakanya ukuhlaziya okuphelele kokwakheka kwamakhemikhali, ubumsulwa, isisindo, i-pHDosity, i-viscosity, i-ph, umswakama okuqukethwe, usayizi wezinhlayiyana, nezimpawu ezisebenzayo ezifana ne-gelation kanye nokwakhiwa kwamafilimu. Amasu ahlukahlukene wokuhlaziya aqashwa ukuhlola la mapharamitha, aqinisekise ukuthi i-HPMC ihlangabezana nokucaciswa okudingekayo kwezicelo zayo ezihlosiwe. Ngokugcina amazinga asezingeni eliphakeme, abakhiqizi be-HPMC bangaqinisekisa ukusebenza ngempumelelo, ukuphepha, kanye nokwenza imisebenzi emikhiqizweni ehlukahlukene.