I-bastic intro ye-HEC ne-HPMC

Isingeniso ku-HEC (HydroxYethyl celtulose) ne-HPMC (Hydroxypropyl Methylcellulose)
I-Hydroxyyethyl celtulose (HEC) neHydroxypropyl Methylcellulose (HPMC) yiminye into ebalulekile yokutholwa kwamaselula asetshenziswe kakhulu ezimbonini ezahlukahlukene, kubandakanya nemithi, ukwakha, ukunakekelwa komuntu siqu nokudla. Kokubili i-HEC ne-HPMC kususelwa ku-cellulose, i-polymer yemvelo eningi kakhulu etholakala ezindongeni zamaseli ezitshalo, ezaziwa ngamandla ayo okuhleleka nokuguquguquka.

I-Hydroxyyethyl cellulose (HEC)
Ukwakheka kwamakhemikhali nezakhiwo
I-Hydroxyyethyl celtulose iyi-nonic, i-polymer engenawo amanzi asuselwa ku-cellulose ngenqubo yokusheshisa. Isakhiwo saso samakhemikhali sifaka amaqembu e-ethylene oxide (-CH2CH2OH) anamathele kwi-cellulose backbone, ethuthukisa i-solubity yayo yamanzi kanye nezakhiwo ezinkulu. I-HEC ivela njengomhlophe ku-powder emhlophe futhi yaziwa ngokusobala kwayo okuphezulu kanye nekhono elihle kakhulu elakha amafilimu.

Inqubo yokuhlanganiswa inqubo
Ukuhlanganiswa kwe-HEC kufaka phakathi ukusabela kwe-cellulose nge-ethylene oxide ngaphansi kwezimo ze-alkaline. Inqubo ngokuvamile ifaka:

I-Alkalization: I-Cellulose iphathwa nge-alkali eqinile, efana ne-sodium hydroxide, ukwakha i-alkali cellulose.
I-Etherification: I-Ethylene oxide bese yengezwa e-Alkali Cellulose, okuholela ekwakhekeni kweHydroxyethyllsose.
Ukungathathi hlangothi nokuhlanzwa: Ingxube yokusabela ayithathi hlangothi futhi ihlanzwa ukuze ikhiphe imikhiqizo eyenziwe ngayo, inikezela ngomkhiqizo wokugcina we-HEC.

Izinja
I-HEC isetshenziswa kuzo zonke izimboni ezahlukahlukene ngenxa yezakhiwo zayo ezihlukile:

Izemithi: Isetshenziswa njenge-ejenti yokuqina, ifilimu-yangaphambili, kanye ne-stabilizer kuma-topical gels, okhilimu, kanye namafutha.
Ukunakekelwa komuntu siqu: Kutholakala kuma-shampoos, ama-conditioners, ama-lotions kanye nama-soaps njengomuntu omkhulu kanye ne-emulsifier.
I-Peints kanye ne-Coatings: Ithuthukisa ukubonwa, ukugcinwa kwamanzi, kanye nezakhiwo ezakha amafilimu kumapende osuselwa emanzini.
Ukwakhiwa: Kusebenza njenge-binder, isikhungo, kanye ne-ejenti yokugcinwa kwamanzi emikhiqizweni esekwe ku-gypsum.
Izinzuzo

I-HEC inikeza izinzuzo eziningana:

Imvelo okungeyona eye-ionic: Ikwenza kuhambisane nohlu olubanzi lwe-ionic nengezona izithasiselo.
I-Solubinity yamanzi: Incibilikisa kalula emanzini abandayo nawe-Hot, akha izixazululo ezicacile.
Ukusebenza kahle kokuqina: kuhlinzeka ngokulawulwa okuhle kwe-viscosity ngokwakhiwa okuhlukahlukene.
I-BioCOMTIL: Kuphephile Ukusetshenziswa emikhiqizweni yokunakekelwa kwemithi neyomuntu siqu.

I-Hydroxypropyl methylcellulose (HPMC)
Ukwakheka kwamakhemikhali nezakhiwo
I-Hydroxypropyllylylylk ingenye i-ether engeyona eye-cellulose, ebonakala ngokufakwa esikhundleni samaqembu e-hydroxy ku-molecule ye-cellulose nge-methoxy (-ch2chohchch3) namaqembu we-hydroxypropyll (-ch2chohchch3). Lokhu kuguqulwa kudlulisela izakhiwo ezihlukile ze-gelation ye-thermal futhi kwenza i-HPMC incibilike emanzini abandayo nawashisayo. I-HPMC iyatholakala futhi njengomhlophe ku-powder emhlophe.

Inqubo yokuhlanganiswa inqubo
Ukukhiqizwa kwe-HPMC kubandakanya inqubo efanayo yokusheshisa:

I-Alkalization: I-Cellulose iphathwa nge-alkali eqinile ukwakha i-Alkali Cellulose.
I-Eletherafication: Inhlanganisela ye-methyl chloride ne-propelene oxide yengezwe e-Alkali Cellulose, okuholele ekwakhekeni kwe-hydroxyproselllylyly methylcellulose.
Ukungathathi hlangothi nokuhlanzwa: Ingxube ayithathi hlangothi, kanye nezinyathelo zokuhlanza zenziwa ukuthola umkhiqizo wokugcina we-HPMC.

Izinja
Ukusebenza okuhlukahlukene kwe-HPMC kuvumela ukuthi isetshenziswe emikhakheni ehlukahlukene:

I-Pharmaceuticals: Isebenza njenge-ejenti yokukhishwa okulawulwayo, i-Binder, kanye ne-Film-coating impahla ekusungulweni kwethebhulethi.
Imboni yokudla: isebenza njengesikhulu, i-stabilizer, kanye ne-emulsifier ekudleni okucutshunguliwe.
Ukwakhiwa: Kusetshenziswe njenge-Swerener, i-ejenti yokugcinwa kwamanzi, kanye nokunamathela ku-masters osuselwa kusawoti kanye nezinhlekelele.
Ukunakekelwa komuntu siqu: kutholakala kumazinyo, ama-shampoos kanye ne-lotions for ukuqina kwawo kanye nokuzinza izakhiwo.

Izinzuzo
I-HPMC ithandelwa ngenxa yezizathu eziningana:

I-gelal ye-Thermal: Imibukiso evikela ukufudumeza, inenzuzo ezihlolweni ezithile zezemithi nokudla.
I-Solubinity: incibilika emanzini andayo nawashisayo, avumela ukusetshenziswa okuguquguqukayo ekwakhiweni okuhlukile.
Ikhono elenziwa ngefilimu: Kwakha amafilimu aqinile, aguqukayo, elungele ukugqoka kanye nokwakhiwa okulawulwa okulawulwayo.
Okungelona ubuthi: Kuphephile ukusetshenziswa kuzinhlelo zokusebenza zezemithi, ngokusebenza okuhle kakhulu.

Ukuqhathaniswa kwe-HEC ne-HPMC
Ukufanayo
Imvelaphi: Zombili zisuselwa ku-cellulose futhi zabelana ngezinqubo ezifanayo zokukhiqiza ezibandakanya ukusheshisa.
Izakhiwo: Kokubili i-HEC ne-HPMC ayiwona ama-ionic, ama-polymers ancibilikisiwe amanzi ngokuqina okuhle, ukwakha amafilimu, kanye nokuzinza izakhiwo.
Izicelo: Zisetshenziswa ezinhlobonhlobo zezimboni, kufaka phakathi ama-Pharmaceuticals, ukunakekelwa komuntu siqu, nokwakha.
Ukwehluka
Amakhemikhali afaka esikhundleni samakhemikhali: I-HEC iqukethe amaqembu we-hpdroxyethyl, ngenkathi i-HPMC inamaqembu we-methoxy nama-hydroxypropyly.
I-Thermal Properties: I-HPMC ikhombisa i-gelation eshisayo, ngokungafani ne-HEC, okwenza ilungele izinhlelo ezithile lapho i-gelation edonswe ukushisa inenzuzo khona.
I-Solubinity: Ngenkathi bobabili bangamanzi, ukuba khona kwamaqembu ama-hydroxypropyl ku-HPMC kuthuthukisa i-solubility yayo kuma-solvents ezi-organic kuqhathaniswa ne-hec.

IHydroxYethyl Cellulose (HEC) neHydroxypropyll Methylcellulose (HPMC) yizinto ezibalulekile ezisetshenziselwa izicelo ezibanzi ngezimboni ezahlukahlukene ngenxa yezakhiwo zazo ezihlukile ngenxa yokusebenza. I-HEC ibaluleke kakhulu ngokusobala kwayo okuphezulu nokuhambisana nezithasiselo ezahlukahlukene, ngenkathi i-HPMC ihlukaniswa yizakhiwo zayo zokufudumala kanye ne-solubity ebanzi. Ukuqonda izakhiwo, ukuhlanganiswa, kanye nokusetshenziswa kwalawa ma-polymers kuyasiza ekukhetheni okufunwa kweselula okufanele kwezidingo ezithile zezimboni, ngaleyo ndlela kuthuthukise ukusebenza kahle kanye nekhwalithi yemikhiqizo yokuphela.