Indlela yokuhlonza elula ye-hydroxypropyllylylylylylyllose (HPMC)

I-Hydroxypropyl Methylcellulose (HPMC) iyingxenye yokwenziwa polymer esetshenziswa kabanzi kwezokwelapha, ukudla, ukwakha, izimonyo kanye nezinye izinkambu. Ine-solubility enhle kakhulu yamanzi, izakhiwo ze-colloidal kanye nokuqina, ngakho-ke inezicelo ezibalulekile ezimbonini ezahlukahlukene. Ukuze uqinisekise ikhwalithi yayo nobumsulwa, ukuhlonza okufanele kudingekile. Lokhu okulandelayo kuyizindlela ezilula zokuhlonza ze-hydroxypropylllylyll methylcellulose (HPMC), ukumboza izici ezifana nokubukeka, ukulekelela, ukusabela kwe-infrared kanye nokusabela kwamakhemikhali.

1. Ukubukeka ukubukeka
I-HPMC imvamisa i-White to Powder emhlophe noma into enomzimba, ngaphandle kwephunga futhi ayinambitha. Ngokubheka ukubukeka kwayo, ungahlulela ngokuvamile noma ngabe kuyi-HPMC emsulwa. Noma yikuphi ukuguqulwa kombala noma ukuba khona kokungcola kungakhombisa ukuthi isampula liyingcola noma lingcolisiwe.

2. Ukukhonjwa kwe-solibity
I-HPMC ine-solubity enhle, ikakhulukazi emanzini. Faka inani elincane lesampula emanzini bese uvusa ngobumnene. Uma kungancibilika ngokushesha futhi kwakha isixazululo se-colloidal somfaniswano, kusho ukuthi isampula yi-hydroxypropyllylylylylyl. Ijubane lokuchithwa kanye nokubonakala kwesixazululo kungahle kuhlobane nesisindo se-molecular se-HPMC nokuqukethwe kwamaqembu we-hydroxypropylyl kanye ne-methyl chemical amaqembu.

Ngasikhathi sinye, i-solubity ye-HPMC kuma-organic solvents nayo ingasetshenziswa njengezinga lokuhlonza. I-HPMC iyanyibilika ku-organic solvents eningi (enjenge-acetone, ethanol, njll.), Kepha insoluble kuma-solvents anamafutha. Lesi sici singaphinde siqinisekiswa ngokuhlola i-solubenity yayo kuma-solvents afanele.

3. Infrared Spectroscopy (IR) Ukukhonjwa
I-Spectroscopy ye-infrared (IR) iyithuluzi elinembile lokuhlonza elingasiza ukuqinisekisa ukwakheka kwe-HPMC. Isici esikhulu sesakhiwo se-HPMC ukufakwa kwamaqembu anjenge-methyl (-CH3) ne-hydroxypropyl (-ch2ch (oh) CH3). Ukuba khona kwalawa maqembu kungaqinisekiswa ngeziqongo zokutholwa kwe-IR Spectrum.

Iziqongo zokumuncwa kwezimpawu ze-HPMC's IR Spectrum zifaka:

2920 cm-1 (ch ukudlidliza ukudlidliza)

I-1450 cm-1 (ch egoba ukudlidliza)

I-1100-1200 cm-1 (i-COC elula vibration)

I-3400 cm-1 (oh yokwelula ukudlidliza, inani eliphakeme lingashintsha ngenxa yokuba khona kwamanzi)

Ngokuqhathanisa i-IR Spectrum yesampula ejwayelekile ye-HPMC, ingaqhathaniswa ne-spectrum yesampula engaziwa ukuqinisekisa ubunikazi besampula.

4. Ukuhlonza amakhemikhali okusabela
I-HPMC, njenge-ether compound, inezici ezithile zokuphendula amakhemikhali futhi ingakhonjwa yimicabango elandelayo yamakhemikhali.

(1) ukusabela ngaphansi kwezimo ze-acidic:
Chaza inani elincane le-HPMC emanzini, engeza i-dilute hydrochloric acid, nokushisa. Uma into ye-colloidal ivela kusisombululo, kusho ukuthi iqukethe i-HPMC. Lokhu kuphendula kungakhonjwa ukuqina kwesakhiwo se-hydroxypropyl kanye namaqembu we-methyl ngaphansi kwezimo ze-acidic.

(2) Ukuphendula ngaphansi kwezimo ze-alkali: I-HPMC iyancibilika emanzini ukwakha ikhambi le-colloidal. Akulula ukuncibilikisa ngaphansi kwezimo ze-alkali (ezifana nesixazululo se-sodium hydroxide), ezihlobene ne-hydrophility yayo ne-hydrogel Properties. Uma isixazululo siseTurbid noma sinembe, kusho ukuthi i-HPMC ikhona.

5 Ngokuvamile, i-HPMC izokwakha into ephilayo enokubonakala okuthile ngemuva kokuncibilika emanzini, futhi ukubonakala kwandiswa ngokwanda kwesisindo sayo samangqamuzana.

Ukuze ulinganise i-viscosity, uketshezi lwesisombululo se-HPMC lungalinganiswa ngokusebenzisa i-vezcometer ejikelezayo noma i-tube tube tube. Ngokwesisindo se-molecular se-HPMC kanye nokuqoqwa kwesixazululo, ukubonwa kwaso kungalinganiselwa. Uma i-viscosity yesampula iphansi kakhulu kunalesosixazululo se-HPMC ejwayelekile, ingakhombisa ukuthi izithako zayo zingcolile noma isisindo samangqamuzana siphansi.

I-6. Ukuncibilikisa Iphoyinti / I-Declomposition Point Test HPMC, njenge-molecular isisindo esiphakeme, imvamisa ayinayo indawo ecacile yokuncibilika, kepha izokhombisa ukuthambisa noma ukubola ngesikhathi sokushisa. Lapho i-HPMC ifudumele, izinguquko zayo emazingeni okushisa ahlukene zingabonakala. Ngokuvamile, i-HPMC izoqala ukubola ngo-180-200 ℃, ikhipha ezinye izinto ezishintshashintshayo (njengamanzi nezinto eziphilayo). Ushintsho kwiphuzu lokubola lungaphinde luqinisekise ukuthi ngabe isampula liyi-HPMC emsulwa.

7. I-Solubity kanye Nendlela Yokungezwani Kwaphezulu
Isixazululo esakhiwe ngemuva kokuthi i-HPMC incithakalo icacile inokungezwani okuphansi komhlaba. Ukungezwani komhlaba kwekhambi le-HPMC kungalinganiswa kusetshenziswa i-tensiometer noma indlela ye-Drip. Uma ifana nengxabano engaphezulu yesisombululo esijwayelekile, kusho ukuthi isampula yi-HPMC.

Lokhu okungenhla kwethula izindlela eziningana ezivamile nezilula zokuhlonza i-hydroxyproppropyll (HPMC). Lezi zindlela zithola i-HPMC kusuka kuma-angles amaningi afana nokubukeka, i-solubity, i-infrared dectrum, ukusabela kwamakhemikhali, ukubonwa kwesampula kungaqinisekiswa ngempumelelo, ukuhlinzeka ngesiqinisekiso sohlelo lwayo ezimbonini ezahlukahlukene.