Ukulungiselela nezakhiwo ze-hydroxypropyllylylym methylcellulose

Hydroxypropyl methylcellulose(I-HPMC) iyisitatimende semvelo se-polymer esinezinsizakusebenza eziningi, ezivuselelekayo, kanye ne-solubility yamanzi enhle nezakhiwo ezakha amafilimu. Kuyinto ebonakalayo eluhlaza eluhlaza kokulungiswa kwamafilimu angenawo amanzi.

Ifilimu yokupakisha enamanzi ngohlobo olusha lwezinto ezisetshenziswayo eziluhlaza, oluthole ukunakwa kakhulu eYurophu nase-United States nakwamanye amazwe. Akuphephile nje kuphela futhi kufanelekile ukusebenzisa, kepha futhi kuxazulula inkinga yokufaka imfucumfucu. Njengamanje, amafilimu ancibilikayo amanzi ikakhulukazi asebenzisa izinto ezenzelwe uphethiloli onjenge-polyvinyl alcohol kanye ne-polyethylene oxide njengezinto ezingavuthiwe. Uphethiloli ungumthombo ongavuselelwa kabusha, futhi ukusetshenziswa okukhulu kwemali kuzodala ukushoda kwezisetshenziswa. Kukhona namafilimu ancibilikiswe amanzi asebenzisa izinto zemvelo ezifana nesitashi namaprotheni njengezinto zokwenziwa kwamanzi, kepha la mafilimu ancibilikisiwe amanzi anezakhiwo ezingezinhle zomshini. Kuleli phepha, uhlobo olusha lwefilimu lokupakisha olungenawo lwamanzi lwalulungiselelwe ngesixazululo esikhundla indlela eyenziwe ngefilimu sisebenzisa i-hydroxypropylylylylylylylyly methylcellulose njengento eluhlaza. Imiphumela yokuhlushwa kwe-HPMC yefilimu ekwakheka amafilimu kanye namazinga okushisa amafulegi emandleni ashukumisayo, e-elongation ngekhefu, ukudluliselwa kokukhanya kanye nokudla kwamanzi kwamafilimu we-HPMC ancibilikisiwe amafilimu. I-Glycerol, i-Sorbibibitl kanye ne-Glutaraldehyde basetshenzisiwe qhubeka nokwenza ngcono ukusebenza kwe-HPMC Exfuble Packeble Packloging File. Ekugcineni, ukuze wandise ukusetshenziswa kwe-HPMC Eboxful Packeble Packloging Fluaging ekupakeni kokudla, i-bamboo leaf antioxidant (AOB) yayisetshenziselwa ukuthuthukisa izakhiwo ze-antioxidant zefilimu ye-HPMC Ebodwa Ebolekayo. Okutholakele okuyinhloko kungokulandelayo:

. Lapho ukugxila kwe-HPMC kungu-5% futhi amazinga okushisa akha amafilimu angu-50 ° C, izakhiwo eziphelele zefilimu le-HPMC zingcono. Ngalesi sikhathi, amandla ashubile acishe abe ngu-116mpa, ukugcwala ekhefu cishe ngo-31%, ukudluliselwa kokukhanya kungama-90%, futhi isikhathi sokudilizwa kwamanzi singama-55min.

. Lapho okuqukethwe i-Glycerol kuphakathi kuka-0.05% no-0.25%, umphumela ungcono kakhulu, futhi i-elongation ekhefu le-hpmc lamanzi angenamanzi ancibilikisiwe afinyelela cishe ama-50%; Lapho okuqukethwe kwe-SORBITOL kungu-0,15%, ukugcwala ekhefu kukhuphuka ku-45% noma ngakho. Ngemuva kwefilimu yokupakisha yamanzi ye-HPMC ye-HPMC yaguqulwa nge-glycerol ne-sorbittol, amandla ashubile kanye nezakhiwo ezibonakalayo zehla, kepha ukwehla kwakungabalulekile.

. Lapho ukwengezwa kwe-glutaraldehyde kwakungu-0.25%, izakhiwo zemishini nezindawo zokubona kwamafilimu afinyelela kulokho okuhle. Lapho ukwengezwa kwe-glutaraldehyde kwakungu-0.44%, isikhathi sokudilizwa kwamanzi sifinyelele kumaminithi ayi-135.

. Lapho kufakwa u-0.03% aob, ifilimu le-AOB / HPMC lalinezinga eliphakeme elingaba ngu-89% lama-radicals wamahhala we-DPPH, kanti ukusebenza kahle kwe-scavengeling bekuphezulu kakhulu, okuyi-61% ephakeme kunaleyo yefilimu ye-HPMC ngaphandle kwe-AOB, futhi i-solubelity yamanzi nayo yathuthukiswa kakhulu.

Amagama asemqoka: ifilimu yokupakisha yamanzi; hydroxypropyl methylcellulose; I-Plistic; Umenzeli oxhumanisayo; i-antioxidant.

Okuqukethwe

Isifinyezo ................................................ ...................................................................................... ...........................................................

Abstract ...............................................................................................................................

Okuqukethwe…………………………………………. .....................................................................................................................................

ISAHLUKO SOKUVIKELA ............................................................ ............................................................................................................. ..1

1.1Water- Filfible film ...................................................................................................................................

1.1.1Polyvinyl Alcohol (PVA) ifilimu lamanzi-seluble-soluble ................................................................................................................................................................................................................................................................................................................................................................................................................................. 1

1.1.2polyethylene oxide (pee) ifilimu elinyibilikayo lamanzi .............................................................

1.1.3.3Starch-based water-soluble film ...............................................................................................................................................................

1.1.4 Ama-Protein-based mater-ancibili amafilimu ancibilikayo .................................................................................................................................

1.2 hydroxypropyll methylcellulose ....................................................................... .. .................................................................

1.2.1 ukwakheka kwe-hydroxypropyllylylylk ..................................................................................................................... .3

1.2.2 Amanzi ane-solubility we-hydroxypropyllylylylylyly .......................................................

1.2.3 Izakhiwo ezenziwe ngefilimu zeHydroxypropylylylylylylyl ........................................................... .4

1.3 Ukuguqulwa kwepulasitiki kwe-hydroxypropyllylylyll methylcellulose film ............................................................... ...4

1.4 Ukuguqulwa okuxhumeka kwesiphambano se-hydroxypropyllm methylcellulose film ......................................................... .5

1.5 Izakhiwo ze-antioxidative ze-hydroxypropyllylyll methylcellulose film .......................................................... Okuthengwa edolo

1.6 Isiphakamiso sesihloko .............................................................................................................. ................................................................. .. .7

1.7 Okuqukethwe kocwaningo ...........................................................................................................................................

Ukulungiswa kweSahluko 2 nezakhiwo ze-hydroxypropyllylylylylylylylylylylylylylylylyl methyllulose amanzi okufaka amaphampu efilimu ...................................................................................................................................................

2.1 ISINGENISO ............................................................................................................................... 8

2.2 Isigaba Sokuhlola .............................................................................................................. ....................................................................... .8

2.2.1 Izinto zokuhlola nezinsimbi ......................................................................................................... ......... ..8.8

2.2.2 Ukulungiselela okucacisiwe ...................................................

2.2.3 Isimo nokuhlolwa kokusebenza .............................................

2.2.4 Ukucutshungulwa kwedatha .................................................................. ........................................................................................................................ 10

2.3 Imiphumela Nengxoxo ...................................................................................................................................................................

2.3.1 Umphumela wokuhlushwa kwezixazululo ekwakheni amafilimu kumafilimu amancanyana we-HPMC kumafilimu amancanyana e-HPMC ............................................................................................................................................................................... Okuthenyalwayo

2.3.2 Ithonya lokushisa kokwakheka kwamafilimu kumafilimu amancanyana e-HPMC .................................................................................................................................................................

2.4 ISAHLUKO SAHUNDWARAMU ...........................................

Imiphumela yeSahluko 3 Semapulasitiki kumafilimu wokupakisha wamanzi we-HPMC angenamsebenzi ........................................................................................................................................................................................................................................................... ..17

3.1 ISINGENISO .........................................................................................................................................................................

3.2 Isigaba Sokuhlola ...................................................................................... ...................................................

3.2.1 Izinto zokuhlola nezinsimbi ...............................................................................................................................

3.2.2 Ukulungiselela okucacisiwe ...............................................................................................................................

3.2.3 Inhlawulo nokuhlolwa kokusebenza .............................................

3.2.4 Ukucutshungulwa kwedatha .................................................................................................. ....................................................... ..19

3.3 Imiphumela Nengxoxo ...................................................................................................................................................................

3.3.1 Umphumela we-glycerol ne-sorbittol kwi-infrared amunction Spectrum yamafilimu amancanyana we-HPMC .....................................................................................................................................................

3.3.2 Umphumela we-glycerol ne-sorbittol kumaphethini we-xrd amafilimu amancanyana e-HPMC .........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................

3.3.3 Imiphumela ye-glycerol ne-sorbittol ezindaweni ezisebenza ngemishini yamafilimu amancanyana e-HPMC .............................................................................................................................................................................................................................................................................................................................................................................................................................................................................

3.3.4 Imiphumela ye-glycerol ne-sorbittol ezindaweni ezibonakalayo zamafilimu we-HPMC ...............................................................................................................................................................................................................

3.3.5 Ithonya le-glycerol ne-sorbittol kuma-solubility amanzi amafilimu we-HPMC .......... 23

3.4 ISAHLUKO SAHUNYEMA .....................................................................................................................................................................

Imiphumela yeSahluko 4 Yama-Crosslinking Agents kumafilimu we-HPMC angenamanzi angenamanzi ancibilikisiwe ...............................................................................................................................................................................................................................................................

4.1 ISINGENISO ............................................................................................................................................................. 25

Isigaba Sokuhlola ...............................................................................................................................................................................

4.2.1 Izinto zokuhlola nezinsimbi ...............................................................

4.2.2 Ukulungiselela okucacisiwe .....................................................

4.2.3 Isimo nokuhlolwa kokusebenza ....................................................... .. .............. .26

4.2.4 Ukucutshungulwa kwedatha .................................................................................................................. ........................................................... ...26

4.3 Imiphumela Nengxoxo .........................................................................................................................................................................................................................................................................................................................................................................

4.3.1 I-infrared amunction spectrum ye-glutaraldehyde-crosslinked HPMC mncane Amafilimu .........................................................................................................................................................................................................

4.3.2 Amaphethini we-XRD we-Glutaraldehyde Cross-Ixhumaze amafilimu amancane we-HPMC ................................... ..27

4.3.3 Umphumela we-Glutaraldehyde kuma-solubility amanzi amafilimu we-HPMC .........

4.3.4 Umphumela we-glutaraldehyde ezingxenyeni zemishini yamafilimu amancanyana we-HPMC ... 29

4.3.5 Umphumela we-glutaraldehyde ezingxenyeni zokubona amafilimu we-HPMC .........................................

4.4 Isahluko Sumfind ..................................................................................................................................................................................................... .. 30

ISAHLUKO SAMAHHALA 5 I-ATRIOXIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDID CAWMC SWEFTALILINA FAMELLE FAMECK MAME ................................... ..31

5.1 ISINGENISO ...............................................................................................................................................................................................

5.2 Isigaba Sokuhlola .......................................................................................................................................................................................

5.2.1 Izinto zokuhlola nezinsimbi zokuhlola .........................................................................................

5.2.2 Ukulungiselela okucacisiwe .............................................................................................................................................................

5.2.3 Isimo nokuhlolwa kokusebenza ....................................................... .. .............................................................................................................................................................

5.2.4 Ukucutshungulwa kwedatha ........................................................................................................ ..................................................................................... 33

5.3 Imiphumela nokuhlaziywa .................................................................................................................................

5.3.1 FT-IR Ukuhlaziywa ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................

5.3.2 Ukuhlaziywa kwe-XRD .........................................................................................................................

5.3.3 Izakhiwo ze-antioxidant .......................................................................................................................................................................

5.3.4 I-solubilicility yamanzi .............................................................................................................................................

5.3.5 Izakhiwo zemishini ...................................................................................................................................................................

5.3.6 Ukusebenza kwe-Optical .........................................................................................................................................................

5.4 ISAHLUKO SAHLUKO .......................................................................................................................................

Isahluko 6 Isiphetho ................................................... ....................................................... ...39

Izinkomba .........................................................................................................................................................................................................................................................................................

Imiphumela yokucwaninga ngezifundo ze-degree ......................................................................................................................................... ..44

Ukuvuma .................................................................................................................................................

ISAHLUKO SOKUVIKELA

Njenge-Novel Green Packal Material, ifilimu yokufaka amanzi isetshenziswe kabanzi ekuphaphaleni kwemikhiqizo ehlukahlukene emazweni aphesheya (njenge-United States, eJapan, eFrance, njll.) [1]. Ifilimu elinyibilika amanzi, njengoba igama lisho, ifilimu epulasitiki engachithwa emanzini. Kwenziwe ngezinto ezisetshenziswayo ze-polymer ezingenamanzi ezingancibilika emanzini futhi zilungiselelwe yinqubo ethile eyakha amafilimu. Ngenxa yezakhiwo zayo ezikhethekile, ilungele kakhulu abantu ukupakisha. Ngakho-ke, abacwaningi abaningi sebeqalile ukunaka izidingo zokuvikelwa kwemvelo kanye nokulula [2].

1.1 Ifilimu elinyibilikayo

Njengamanje, amafilimu ancibilikayo amanzi anamafilimu ancibilikisiwe amanzi asebenzisa izinto ezisuselwa emanzini njenge-polyvinyl alcohol kanye ne-polyethylene oxide njengezinto zokwakha, namafilimu ancibilikayo asebenzisa izinto zemvelo ezifana nezinto zokwakha.

1.1.1 I-Polyvinyl Alcohol (PVA) Ifilimu elinyibilikisiwe

Njengamanje, amafilimu asetshenziswa kakhulu asetshenziswa kakhulu emhlabeni emhlabeni ikakhulukazi amafilimu we-PVA ancibilikisiwe. I-PVA i-vinyl polymer engasetshenziswa ngamagciwane njengomthombo wekhabhoni nomthombo wamandla, futhi ingaboshelwa ngaphansi kwesenzo se-bacterium nama-enzymes [3], ukumelana nomoya kanye nezakhiwo zesithiyo segesi kanye ne-gesi izithiyo zegesi [4]. Ifilimu yePVA inezakhiwo ezinhle zemishini, ukuzivumelanisa nezimo okuqinile nokuvikelwa okuhle kwemvelo. Kusetshenziswe kabanzi futhi ineziqu eziphakeme zokuhweba. Kuyinto esetshenziswa kakhulu esetshenziswa kakhulu nefilimu yokupakisha yamanzi enkulu kunazo zonke emakethe [5]. I-PVA inokuwonakaliswa okuhle futhi ingaboshelwa ama-microorganisms ukukhiqiza i-CO2 ne-H2O enhlabathini [6]. Iningi locwaningo ngamafilimu ancibilikisiwe amanzi manje ukuguqula nokuzihlanganisa ukuze uthole amafilimu angcono ancibilikisiwe amanzi. UZhao Linlin, Xiong Hanguo [7] ufundele ukulungiswa kwefilimu epakisha yamanzi nge-PVA njenge-main esetshenziswayo ngokuhlolwa kwe-orthogonal, i-glycen 5%, i-sodium dodecyl sulfate (SDS) 4%. Ngemuva kokumiswa kwe-microwave yefilimu etholakele, isikhathi esinyibilikayo emanzini emanzini okushisa asekamelweni yi-101s.

Uma kuhlulela esimweni sokucwaninga samanje, ifilimu le-PVA lisetshenziswa kabanzi, izindleko eziphansi, futhi lihle kakhulu ezakhiweni ezahlukahlukene. Kuyinto ephelele emanzi angenamkhawulo emanje. Kodwa-ke, njengezinto ezisekelwe petroleum, i-PVA ingumthombo ongavuselelwa, futhi inqubo yayo yokukhiqiza engavuthiwe ingahle ingcoliswe. Yize i-United States, iJapan namanye amazwe bakufake njengento engeyona into enobuthi, ukuphepha kwako kusavulekele ukubuza. Kokubili ukuphefumula nokungena kuyingozi emzimbeni [8], futhi akunakubizwa ngokuthi i-chemistry eluhlaza ephelele.

1.1.2 polyethylene oxide (peo) ifilimu elinyibilikisiwe

I-polyethylene oxide, eyaziwa nangokuthi i-polyethylene oxide, i-thermoplastic, i-polymer enamanzi engaxutshwa namanzi kunoma yisiphi isilinganiso sokushisa [9]. Ifomula yesakhiwo se-polyethylene oxide yi-H - (- OCH2CH2-) n-Oh, futhi isisindo salo esilinganiselwe sizothinta isakhiwo saso. Lapho isisindo se-molecular sisebangeni lama-200 ~ 20000, libizwa nge-polyethylene glycol (isikhonkwane), futhi isisindo samangqamuzana sikhulu kune-20,000 ingabizwa ngokuthi i-polyethylene oxide (abantu) [10]. I-peos iwumpuphu we-granural emhlophe, okulula ukucubungula kanye nokwakheka. Amafilimu e-pee avame ukulungiswa ngokungeza amapulasitiki, abaqinisi kanye nabasizi babantu abahleli be-Permoplastic ukucubungula [11].

Ifilimu ye-Pee CEE CEE iyimanga enamanzi ancibilikisiwe ngamanje, futhi izakhiwo zalo zemishini nazo zinhle, kepha abantu banezimo ezizinzile, kanye nenqubo yokuncipha kancane emvelweni, futhi iningi lemisebenzi emikhulu lingasetshenziswa. I-PVA Film Alternative [12]. Ngaphezu kwalokho, futhi futhi kunobuthi obuthile, ngakho-ke akuvamile ukusetshenziswa kumaphakeji womkhiqizo [13].

1.1.3 Ifilimu elisuselwa emanzini

Isitashi i-polymer ephezulu ye-moleculale ephezulu, futhi ama-molecule awo aqukethe inani elikhulu lamaqembu ama-hydroxyl, ngakho-ke kukhona ukuxhumana okunamandla phakathi kwama-molecule wesitashi, ngakho-ke ukuthi isitashi sinzima ukuncibilika futhi sisebenze, futhi kunzima ukuxhumana namanye ama-polymers. Kuhlanganiswe ndawonye [14,15]. I-solubility yamanzi yesitashi impofu, futhi kuthatha isikhathi eside ukugcwala emanzini abandayo, ngakho-ke isitashi esiguquliwe, okungukuthi, isitashi esinyibilikayo samanzi, kuvame ukusetshenziselwa ukulungiselela amafilimu ancibilikise amanzi. Ngokuvamile, isitashi siguqulwa ngamakhemikhali ngezindlela ezifana nokuchazwa, ukugcwala, ukuxhunyelelwa, ukuxhumanisa ukuguqula ukwakheka kwesitashi, ngaleyo ndlela kuthuthukise i-solubility yamanzi [7,16].

Yazisa amabhondi e-ether emaqenjini amakhemikhali ngezindlela zamakhemikhali noma usebenzise ama-oxidants aqinile ukushabalalisa isakhiwo se-starch esisezingeni eliphakeme sokuthola isitashi esingcono [17], kanye nokuthola isitashi esincibilikisiwe samanzi ngezindawo ezingcono zefilimu. Kodwa-ke, kumazinga okushisa aphansi, ifilimu yesitashi inempahla embi kakhulu emishini kanye nokusobala okusobala, ngakho-ke ezimweni eziningi, kudinga ukulungiswa ngokuxubana nezinye izinto ezifana ne-PVA, futhi inani langempela lokusebenzisa aliphezulu.

1.1.4 Amanzi asuselwa emanzini ancibilikayo

Amaprotheni yinto esebenza ngemvelo esebenzayo yemvelo equkethwe ezilwaneni nasezitshalweni. Njengoba iningi lentengo lamaprotheni liyafakwa emanzini emazingeni okushisa asekamelweni, kuyadingeka ukuxazulula insongi yamaprotheni emanzini emazingeni okushisa asekamelweni ukulungiselela ama-protence anezinhlaka. Ukuze athuthukise ukugcwala kwamaprotheni, adinga ukuguqulwa. Izindlela ezijwayelekile zokuguqulwa kwamakhemikhali zifaka i-dephlalemination, i-phthaamidation, phosphorylation, njll. [18]; Umphumela wokuguqulwa uwukushintsha isakhiwo sezicubu zeprotheni, ngaleyo ndlela akhuphuke i-solubity, i-gelation, ukusebenza okufana nokutholwa kwamanzi nokuqina kuhlangabezana nezidingo zokukhiqiza nokusebenza. Ama-Protein asuselwa emanzini ancibilikisiwe amanzi akhiqizwa ngokusebenzisa imfucumfucu yomkhiqizo wezolimo ne-sideline efana nokwenza izinwele zezilwane njengezinto zokwakha amaprotheni, ngaphandle kwesidingo semboni ye-petrochemical, futhi izinto zokwakha zivuselelwa futhi zinomthelela omncane emvelweni [19]. Kodwa-ke, amafilimu ancibilikayo amanzi alungiselelwe amaprotheni afanayo ne-matrix enezindawo ezingezinhle zemishini kanye ne-solubity enamanzi aphansi emazingeni okushisa aphansi noma amazinga okushisa aphansi, ngakho-ke uhla lwabo lwesicelo luncane.

Ukufingqa, kubaluleke kakhulu ukuthuthukisa impahla yamafilimu entsha, evuselelekayo, engenamanzi engenakuqhathaniswa nokusebenza okuhle kakhulu ukwenza ngcono ukushiyeka kwamanje kwamafilimu wamanje ancibilikisiwe.

I-Hydroxypropyll methyl cellulose (i-hpdroxypropyl methyl celtule, i-HPMC yamafuphi) iyinto enezinto zemvelo ze-polymer, kodwa futhi ingenabungozi, ingenabungozi, insizakalo ephansi, hhayi yokuncintisana nabantu bemvelo [20]]. Ine-solubility yamanzi enhle nezakhiwo ezenziwe ngefilimu, futhi inemibandela yokulungiselela amafilimu angenamanzi angenamanzi.

1.2 hydroxypropyllylyly methylcellulose

I-Hydroxypropyll methyl cellulose (i-hpdroxypropyl methyl celtule, i-HPMC yamafuphi), nayo ifinyezwe njenge-phpromellose, itholakala kwi-cellulose yemvelo ngokwelashwa kwe-alkalization, ukuguqulwa kwemvelo, ukusabela kokungathathi hlangothi nezinqubo zokugeza kanye nokuhlanza izinqubo zokugeza kanye nokugeza nezinqubo zokugeza kanye nokuhlanza nezinqubo zokugeza kanye nokugeza nezinqubo zokugeza kanye nokugeza nezinqubo zokugeza kanye nokugeza nezinqubo zokugeza kanye nokugeza nezinqubo zokugeza. I-cellulose engenawo amanzi okususelwa [21]. I-Hydroxypropylm methylcellulose inezimpawu ezilandelayo:

(1) Imithombo echichimayo futhi evuselelekayo. Izinto ezivuthiwe ze-hydroxypropyllylylyly iyisimo se-cellulose yemvelo eningi kakhulu emhlabeni, okungokwezisetshenziswa ezivuselelekayo ezivuselelekayo.

(2) Imvelo nemvelo enobungane ne-biodebradable. I-Hydroxypropylm methylcellulose ayilona ubuthi futhi ayinabungozi emzimbeni womuntu futhi ingasetshenziswa emithini nasezimbonini zokudla.

(3) Uhla olubanzi lokusebenzisa. Njenge-polymer-soluble polymer, i-hydroxypropyllylylylyllose ine-solubiling enhle yamanzi, ukusakazeka, ukuqina, ukugcinwa kwamanzi kanye namakhemikhali okwakha amafilimu, futhi kungasetshenziswa ukudla, amakhemikhali ama-elekthronikhi kanye nezinye izinkambu zezimboni [21].

1.2.1 Ukwakheka kwe-hydroxypropylllylyll methylcellulose

I-HPMC itholakala kwi-cellulose yemvelo ngemuva kokuzalwa kwe-alkaliset, futhi ingxenye yePolyhydroxypropylll ther ne-methyl inethezekile nge-oxide ne-methyl chloride. I-HPMC methyl subrience ejwayelekile ye-HPMC methyl subdigree evela ku-1.0 kuya ku-2.0, kanye ne-hydroxypropyl aphakathi degree degree degree kusuka ku-0.1 kuya ku-1.0. Ifomula yayo yamangqamuzana ikhonjiswa kuMfanekiso 1.1 [22]

Ngenxa yokubopha okuqinile kwe-hydrogen phakathi kwama-macromolecule wemvelo we-cellulose, kunzima ukuncibilikisa emanzini. I-solubility ye-cellulose etheleleke emanzini ithuthukiswa kakhulu ngoba amaqembu e-ether angeniswa emgqonyeni we-cellulose, obhubhisa ama-hydrogen aphakathi kwama-molecule e-cellulose futhi andise i-solubity yayo emanzini [23]]. I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano ejwayelekile ye-hydroxyaalkyl Alkyl yeqembu ngalinye. - [OCH2CH (CH3)] n oh the hydroxyl geroar ekugcineni kwe-n oh group yiqembu elisebenzayo, elingase liphinde lisebenze, futhi ichungechunge elithile le-hydroxyalky, elinomthelela othile wangaphakathi wepulasitiki ocingweni lwe-macromoleklar; -Iqembu le-End-capping, indawo yokuphendula izokwenziwa ngemuva kokufaka esikhundleni sokufakwa esikhundleni, futhi ingeyeqembu le-hydrophobic elilungiselelwe [21. Amaqembu e-hydroxyl kwi-chain entsha yegatsha elisanda kufakwa kanye namaqembu we-hydroxyl asele ngezinsalela ze-glucose angashintshwa ngamaqembu angenhla, okuholela ezinhlakeni eziyinkimbinkimbi kakhulu kanye nezakhiwo eziguqukayo ngaphakathi kwebanga elithile lamandla angu-24.

1.2.2 Amanzi Elubility ye-hydroxypropyllylyll methylcellulose

I-Hydroxypropyllylylylylylys inezakhiwo eziningi ezinhle kakhulu ngenxa yesakhiwo sayo esiyingqayizivele, okuphawuleka kakhulu kwako okuthi yi-solubity yayo yamanzi. Iyagwinya kwikhambi le-colloidal emanzini abandayo, futhi ikhambi linomsebenzi othile ongaphezulu, ukucaca okuphezulu nokusebenza okuzinzile [21]. I-Hydroxypropylylylylk empeleni i-cellulose ether etholwe ngemuva kokuthi i-methylcellose iguqulwe yi-propylene oxide ukusheshisa nokungafakwa emanzini okuvuthayo [21], kanye namanzi alona amanzi afanayo. I-methyl celtulose idinga ukubekwa ku-0 kuye ku-5 ° C imizuzu engama-20 kuye kwengama-40 ukuthola isisombululo somkhiqizo ngokusobala okuhle nokubonakaliswa okuzinzile [25]. Isixazululo se-hydroxypropyllllylylylyllose umkhiqizo udinga kuphela ukuba ngu-20-25 ° C ukufezekisa ukuzinza okuhle nokubonakala okuhle [25]. Isibonelo, i-hydroxypropproserprose methylcellulose (ukwakheka kwe-gramusa

1.2.3 Izakhiwo ezenziwe ngefilimu ze-hydroxypropylylylylylylylym methylcellulose

I-Hydroxypropylllylylylyl methylcellulose solution inezakhiwo ezinhle kakhulu zefilimu, ezinganikeza izimo ezinhle zokuhlanganiswa kwamalungiselelo emithi. Ifilimu ehlanganayo eyakhiwa yi-Colorsless, I-Odorless, enzima futhi esobala [21].

U-Yan Yanzhong [26] wasebenzisa isivivinyo se-orthogonal ukuphenya izakhiwo ezakha amafilimu ze-hydroxypropylyll methylcellulose. Ukuhlolelwa kwenziwa emazingeni amathathu anokugxila okuhlukile nama-solvents ahlukile njengezici. Imiphumela ikhombisile ukuthi ukwengeza i-10% hydroxypropyllllt methylcellulose ku-50% isixazululo se-ethanol saba nezakhiwo ezinhle kakhulu zefilimu, futhi zingasetshenziswa njengezinto ezenzelwe amafilimu zamafilimu wezidakamizwa agciniwe.

1.1 Ukuguqulwa kwepulasitiki kwe-hydroxypropyllyllose methylcellulose film

Njengomsebenzi ovuselelekayo wemvelo, ifilimu elungiselelwe kusuka ku-cellulose njengento eluhlaza inokuqina okuhle nokukhononda, futhi kuyinto enganakwa lutho ngemuva kokulahlwa kwemvelo. Kodwa-ke, amafilimu ama-cellulose angabonakali anobunzima obubi, futhi i-cellulose ingahle ifakwe ngopulasitiki futhi iguqulwe.

[27] Kusetshenziswe Triethyl Citrate kanye ne-ACETYL TETRABUTYL CITRALE UKUZE UQHAWULEKILE KANYE P lula Imiphumela ikhombisile ukuthi ukunwebeka ekwephuleni kwefilimu ye-cellulose acetate proplionate ifilimu kukhuphuke ngo-36% no-50% lapho ingxenye enkulu ye-Triethyl citrate kanye ne-acetyl tetrabutyl kanye ne-acetyl tetrabutyl ne-10%.

ULuo Qiushui et al [28] watadisha imiphumela yamapulasitiki Glycerol, i-steartic acid kanye ne-glucose ezingxenyeni zemishini ze-methylcellulose membranes. Imiphumela ikhombisile ukuthi izinga eliphakeme le-methyllllile membrane lalingcono lapho okuqukethwe kwe-glycerol bekungu-1.5%, kanti isilinganiso se-methyllsle

I-Glycerol iwuketshezi olungenamibala, olumnandi, olucacile, olubonakalayo ngokunambitheka okumnandi okufudumele, okwaziwa kakhulu ngokuthi i-glycerin. Ilungele ukuhlaziywa kwezixazululo zamanzi, amathambi, amapulasitiki, njll. Ingachithwa ngamanzi kunoma yisiphi isilinganiso, kanye nesixazululo se-Glycerol solution esiphansi singasetshenziswa njengokuthathela uwoyela ukuze kuthathwe uwoyela. I-Sorbibibitol, i-hygroscopic emhlophe noma i-crystalline powder, ama-flales noma amagremu, amaphunga. Inemisebenzi yokutholwa komswakama nokugcinwa kwamanzi. Ukungeza okuncane ekukhiqizeni i-CHEWING GUM noswidi kungagcina ukudla kuthambile, kuthuthukise inhlangano futhi kunciphise ukuqina futhi kudlale indima yesihlabathi. I-Glycerol ne-Sorbibibity zombili izinto ezincibilikayo, ezingahlanganiswa ne-cellulose afellule-23]. Zingasetshenziswa njengamapulangwe epulasitiki e-cellulose. Ngemuva kokungeza, bangathuthukisa ukuguquguquka nokubumbana lapho kwekhefu lwamafilimu we-cellulose. [29]. Ngokuvamile, ukugcwala kwesixazululo kungu-2-5%, futhi inani lesesimo lingu-10-20% we-cellulose ether. Uma okuqukethwe kwepulasitiki kuphezulu kakhulu, i-shrinkage ye-shrinkan ye-colloid dehydration izokwenzeka ekushiseni okuphezulu [30].

1.2 Ukuguqulwa kwe-crosslinking ye-hydroxypropylllllm methylcellulose film

Ifilimu elinyibilikayo lamanzi linamanzi amahle we-solubity, kepha akulindelekile ukuthi lihlaze ngokushesha lapho lisetshenziswa kwezinye izikhathi, njengezikhwama zokufaka imbewu. Imbewu isongwe ngefilimu elinyibilikayo, elingakhulisa izinga lokusinda lembewu. Ngalesi sikhathi, ukuze uvikele imbewu, akulindelekile ukuthi ifilimu izoncipha ngokushesha, kepha ifilimu kufanele iqale idlale umphumela othile wokugcina amanzi embewini. Ngakho-ke, kuyadingeka ukwandisa isikhathi esinyibilikayo samafilimu. [21].

Isizathu esenza i-hydroxypropyllllllylyl ine-solubening enhle yamanzi ukuthi kunenombolo enkulu yamaqembu e-hydroxyl ehlelweni lawo ama-hydroxydes ukwenza ama-hydroxyprosel reaks methylcellose amaqembu e-hydroxypropylwose we-hydroxypropylyl methylcellulose ancishisiwe, ngaleyo ndlela Ukunciphisa i-solubility yamanzi ye-hydroxypropyllyllose film, kanye nokusabela okuxhumanisa phakathi kwamaqembu ama-hydroxyl nama-aldehydes kuzokhiqiza izibopho eziningi zamakhemikhali, ezingathuthukisa nezindawo zemishini yefilimu ngezinga elithile. Ama-Aldehydes axhumene ne-hydroxypropylylylylykyl methylcellose afaka i-glutaraldehyde, i-glyoxal, i-formaldehyde, njll. Kuphephile, ngakho-ke i-Glutaraldehyde ngokuvamile isetshenziswa njenge-ejenti exhumanisa nokuxhuma kwabaphethe. Inani lalolu hlobo lwe-ejenti elixhumanisa isixazululo ngokuvamile liyi-7 kuye ku-10% yesisindo se-ether. Izinga lokushisa lokwelashwa licishe libe ngu-0 kuye ku-30 ​​° C, futhi isikhathi siyimizuzu eyi-1 ~ 120 [31]. Ukusabela okuxhumanisa ngokuwela kudinga ukwenziwa ngaphansi kwezimo ze-acidic. Okokuqala, i-acid ye-acid enamandla ye-inorganic noma i-organic carboxylic yengezwe kwikhambi ukuguqula i-PH yesisombululo esingaba ngu-4-6, bese ama-aldehydes angeziwe ekwenzeni ukusabela okuxhumanisayo [32. Ama-Acid asetshenzisiwe afaka i-HCL, H21SO4, i-acetic acid, i-citric acid, nokunye okunjalo. I-acid ne-aldehyde nayo ingangezwa ngasikhathi sinye ukwenza ikhambi lifeze ukusabela okuxhumanisayo ku-PH Range oyifunayo [33].

1.3 Izakhiwo ze-antioxidative of hydroxypropyllyllyll methylcellulose films

I-Hydroxypropyllylylylylyly icebe izinsizakusebenza, kulula ukwakha ifilimu, futhi inomphumela omuhle wokugcina omusha. Njengokugcina kokugcina, inekhono elikhulu lokuthuthuka [34-36].

UZhuang Rongyu [37] wasebenzisa i-hydroxyproppropylllyllose (hpmc) ifilimu edliwayo, wayibopha ngotamatisi, wabe eseyigcinele ngo-20 ° C izinsuku eziyi-18 ukutadisha ukuqina kwayo nombala wayo. Imiphumela ikhombisa ukuthi ubunzima be-utamatisi nge-HPMC coating buphakeme kunalokho ngaphandle kokugoqa. Kwafakazelwa nokuthi ifilimu edliwayo ye-HPMC ingabambezela ukuguqulwa kombala utamatisi kusuka pink kuya obomvu lapho kugcinwa ngo-20 ℃.

[38] Ufunde imiphumela ye-hydroxypropyllyllop methylcellulose (HPMC) Ukwelashwa ngekhwalithi, ukuhlanganiswa kwe-anthocyanin kanye nomsebenzi we-antioxidant we- "Wuzhong" Bayberry Four ngesikhathi sokugcinwa okubandayo. Imiphumela ikhombisile ukuthi ukusebenza kwe-anti-oxidation ye-bayberry ephathwe ngefilimu ye-HPMC kwenziwa ngcono, futhi izinga lokubola ngesikhathi sokulondolozwa sehlile, futhi umphumela wefilimu elingu-5% HPMC lalihamba phambili.

Wang kaikai et al. [39] esetshenzisiwe "I-Wuzhong" Bayberry izithelo njengezinto zokuhlola ukutadisha umphumela we-humdylypropprosel methylcelloser methylcellop (hpmc) ikhwalithi ye-hydroxcellopprosel methylcelloser methylcellulose (HPMC) ikhwalithi ye-hydlxelropprosel methylcellulose (HPMC) Ikhwalithi yekhwalithi kanye ne-antioxidant impahla ye-baybervest izithelo ngesikhathi sokugcina ngo-1 ℃. umphumela womsebenzi. Imiphumela ikhombisile ukuthi izithelo ze-barberry-ze-bayberry ze-riboflavin-composite zisebenza kakhulu kune-riboflavin noma i-HPMC ehlanganisiwe, ukunciphisa ngempumelelo izinga lokubola kwezithelo ze-bayberry ngesikhathi sokugcina, lapho kuqhubeka isikhathi sesitoreji sezithelo.

Eminyakeni yamuva, abantu banezidingo eziphakeme neziphakeme zokuphepha kokudla. Abaphenyi ekhaya nakwamanye amazwe bashintshe kancane kancane ukugxila kwabo kokucwaninga ngezimali zokudla ezintweni ezifakwayo. Ngokungeza noma ukufafaza ama-antioxidants ezintweni zokupakisha, zinganciphisa i-oxidation yokudla. Umphumela wezinga lokubola [40]. Ama-antioxidants zemvelo akhathazeke kabanzi ngenxa yokuphepha kwawo okuphezulu nemiphumela emihle yezempilo emzimbeni womuntu [40,41].

I-Antioxidant yamaqabunga e-bamboo (aob amafuphi) iyi-antioxidant yemvelo enephunga lemvelo lemvelo lemvelo kanye ne-solubity yamanzi enhle. Kubhalwe ku-National Standard GB2760 futhi yavunywa uMnyango Wezempilo njenge-antioxidant yokudla kwemvelo. Ingasetshenziswa futhi njengesengezo sokudla semikhiqizo yenyama, imikhiqizo yasemanzini kanye nokudla okukhukhumele [42].

ILanga Lina njll. [42] Kubukezwe izakhi eziphambili nezakhiwo zama-bamboo leaf antioxidants futhi wethule ukusetshenziswa kwama-bamboo amaqabunga ama-antioxidants ekudleni. Ukungeza i-0.03% AOB kumayonnaise entsha, umphumela we-antioxidant ubonakala kakhulu ngalesi sikhathi. Qhathanisa nenani elifanayo lama-antioxidants e-telphenol, umphumela wawo we-antioxidant ngokusobala ungcono kunaleso sama-polyphenols wetiye; Ukungeza u-150% kubhiya ku-MG / L, izakhiwo ze-antioxidant kanye nokuqina kwesitoreji kukhuphuke kakhulu, futhi ubhiya unokuhambisana okuhle nomzimba wewayini. Ngenkathi uqinisekisa ikhwalithi yangempela yomzimba wewayini, futhi kwandisa iphunga nokunambitheka okuqondile kwamaqabunga ama-bamboo [43].

Ngamafuphi, i-hydroxypropyl methylcellulose inezakhiwo ezinhle ezenziwe ngamafilimu kanye nokusebenza okuhle kakhulu. Kuyinto futhi eluhlaza okotshani nokungcola, engasetshenziswa njengefilimu yokupakisha emkhakheni wokufaka [44-48]. I-Glycerol ne-Sorbibitlol zombili zepulasitiki ezincibilikayo. Ukungeza i-Glycerol noma i-SorbibitoL kukhambi elakha amafilimu we-cellulose kungathuthukisa ubulukhuni be-hydroxypropylyllose film, ngaleyo ndlela kwamukele ukugcwala ekhefu lefilimu [49-51]. I-Glutaraldehyde iyisibulala magciwane esivame ukusetshenziswa. Uma kuqhathaniswa namanye ama-Aldehydes, kuphephile, futhi kune-DialdHyde Group ku-molecule, kanye nejubane lokuxhumanisa ngokuhamba ngokushesha. Ingasetshenziswa njengokuguqulwa okuxhumeka kwesiphambano se-hydroxypropyllllyrprose methylcellulose film. Ingaguqula i-solubility yamanzi yefilimu, ukuze ifilimu lisetshenziswe ngezikhathi eziningi [52-55]. Ukungeza ama-bamboo amaqabunga ama-antioxidants ku-hydroxypropyllyrpropyl methylcellulose film ukuthuthukisa izakhiwo ze-antioxidant ze-hydroxypropylylylylylylylylylylylylylylylylylylyllose film futhi wandise uhlelo lokusebenza lwayo ekupakisweni kokudla.

1.4 Isiphakamiso sesihloko

Kusuka esimweni sokucwaninga samanje, amafilimu ancibilikayo amanzi ikakhulukazi ahlanganiswa ngamafilimu e-PVA, amafilimu asuselwa esitokisini kanye namaprotheni asuselwa emanzini asuselwa emanzini. Njengezinto ezisekelwe petroleum, i-PVA kanye nabantu bayizinsizakusebenza ezingavuselelwa, futhi inqubo yokukhiqiza yezinto zabo eziluhlaza ingangcoliswa. Yize i-United States, iJapan namanye amazwe bakufake njengento engeyona into enobuthi, ukuphepha kwako kusavulekele ukubuza. Kokubili ukuphefumula nokungena kuyingozi emzimbeni [8], futhi akunakubizwa ngokuthi i-chemistry eluhlaza ephelele. Inqubo yokukhiqiza yezinto zokwelulwa zamanzi ezisuselwa ku-starch kanye namaprotheni ayinangozi futhi umkhiqizo uphephile, kepha unobubi bokwakheka kwefilimu kanzima, ukunwebeka okuphansi kanye nokuqhekeka okulula. Ngakho-ke, ezimweni eziningi, kudingeka zilungiselelwe ngokuxuba nezinye izinto ezifana ne-PVA. Inani lokusebenzisa aliphezulu. Ngakho-ke, kubaluleke kakhulu ukuthuthukisa impahla yefilimu entsha, evuselelekayo, engenamanzi engenakuqhathaniswa nokusebenza okuhle kakhulu ukwenza ngcono iziphambeko zefilimu yamanje enamanzi.

I-Hydroxypropylm methylcellulose iyinto ebonakalayo yemvelo ye-polymer, engacebisi kuphela kwizinsizakusebenza, kodwa futhi ivuseleleke. Ine-solubility yamanzi enhle nezakhiwo ezenziwe ngefilimu, futhi inemibandela yokulungiselela amafilimu angenamanzi angenamanzi. Ngakho-ke, leli phepha lihlose ukulungiselela uhlobo olusha lokupakisha amanzi nge-hydroxypropyly methylcellulose njengezinto eziluhlaza, futhi ngeze zihlelekile ngezimo zokulungiselela (i-glycerol kanye ne-sorbitol). ), i-ejenti exhumanisa (i-Glutaraldehyde), i-antioxidant (bamboo leaf antioxidant), futhi ithuthukise izakhiwo zayo, ukuze ilungiselele iqembu le-hydroxypropyl ngempahla ebanzi ebanzi njengezindawo zemishini, izakhiwo zamanzi, i-antioxidant Properties. Ifilimu yokupakisha yamanzi engenamanzi engenakuvulwa yamanzi ibaluleke kakhulu ngohlelo lokusebenza njengezinto ezifakwayo zamafilimu angenamanzi.

1.5 Okuqukethwe kocwaningo

Okuqukethwe kocwaningo kungokulandelayo:

1) Ifilimu lokufaka amanzi le-HPMC lilungiselelwe ngesisombululo sokuphonsa indlela eyakha amafilimu, futhi izakhiwo zefilimu zahlaziywa ukutadisha ithonya lokuqunjelwa kwe-HPMc film yefilimu kanye namazinga okushisa angenamanzi we-HPMC.

2) Ukutadisha imiphumela ye-glycerol ne-sorbittol sporic

3) Ukutadisha umphumela we-ejenti yokuxhumanisa i-Glutaraldehyde e-solubity yamanzi, izakhiwo zemishini kanye nezindawo zokubona kwamafilimu okupakisha amanzi we-HPMC.

4) Ukulungiselela i-AOB / HPMC Exluble Packeble Fpack FACHELL. Ukumelana ne-oxidation, i-solubility yamanzi, izakhiwo zemishini kanye nezindawo zokubona amafilimu a-aob / hpmc afundwayo.

Isahluko 2 Ukulungiselela Nezakhiwo zeHydroxypropylylylylylylylylylylylylylylylyrkylyllopylyl methyl cellulose Amanzi okupakisha amanzi

2.1 Isingeniso

I-Hydroxypropyll methylcellulose iyinhlangano etholwa yimvelo yemvelo. Akulona ubuthi, ukungangcolisi, okuvuselelekayo, okuzinzile, futhi kunamanzi amahle we-solubility kanye nezakhiwo ezenziwe ngefilimu. Kuyinto engaba khona yefilimu engenamakhi yefilimu.

Lesi sahluko sizosebenzisa i-hydroxypropyll methylcellulose njengezinto ezingavuthiwe ukulungiselela i-hydroxypropylllylylylylylylylylylylylylylylylylylylylylylylylylylylylylylylylylylylylylyl methylcellulose solution nge-2% kuya ku-6% Izakhiwo zekristalu zefilimu zazibonakaliswa yi-X-RAY PREFRACTION, namandla ashukumisayo, ukukhishwa kwekhefu kanye ne-haze ye-hydroxypropyll film ye-methdypropyll methyling methylcellulose methylinglel methylingl methylingl methylingl methylingl methyling methylcellulose methyliats methylcellulose ifilimu lokuhlola amanzi kanye nokuhlolwa kwamanzi kanye ne-solubity amanzi.

2.2 UMnyango Wezokuhlola

2.2.1 izinto zokuhlola nezinsimbi

2.2.2 Ukulungiselela

1) Isisindo: Linganisa inani elithile le-hydroxypropyllylyll methylcellulose ngebhalansi ye-elektroniki.

2) Ukuchithwa: Faka isisindo se-hydroxypropyll methylcellulose kumanzi alungiselelwe alungiselelwe, uvuse ekushiseni okujwayelekile kanye nengcindezi kuze kube yilapho ichithiwe ngokuphelele, bese uyivumela imele isikhathi esithile sokwakheka okuthile. ulwelwesi lwe-membrane. Kwenziwe ngo-2%, 3%, 4%, 5% no-6%.

3) Ukwakheka kwefilimu: ① Ukulungiselela amafilimu anezixazululo ezahlukahlukene zefilimu: Faka izixazululo zokwakha amafilimu ze-HPMC zokugxila okuhlukile ezitsheni ze-Pelri ezihlukile ukuze zikhohlise amafilimu, bese ziwabeka kuhhavini omiswe ngo-40 ~ 50 ° C ukuze zome futhi wakhe amafilimu. Ifilimu ye-hydroxypropyll methylcellose filk yokufaka amanzi anobukhulu bama-25-50 μm alungisiwe, futhi ifilimu ihlutshiwe bese ifakwa ebhokisini lokomisa. I-②prepation yamafilimu amancane anemivimbi ehlukene eyakha ifilimu (amazinga okushisa ngesikhathi sokwakha kanye nefilimu) I-hydroxypropyll methyllellose ifilimu yokupakisha yamanzi enobukhulu obungama-45 μm yalungiswa, futhi ifilimu lafulathwa lifakwe ebhokisini lokomisa elizosetshenziswa. I-hydroxyproppropyllose methylcellulose amafilimu okupakisha amanzi ane-soluble abizwa ngokuthi yi-HPMC ifilimu elifushane.

2.2.3 Isimo nokulinganisa ukusebenza

2.2.3.1 Wide-Angle X-RAY IQINISO (XRD) Ukuhlaziywa

I-Wide-Angle X-RAY TAGRACTION (XRD) ihlaziya isimo se-crystalline sento ezingeni lamangqamuzana. I-x-ray diffractometer ye-arl / xtra uhlobo olukhiqizwe yi-Thermo Arl inkampani eSwitzerland yasetshenziselwa ukuzimisela. Izimo Zokulinganisa: Umthombo we-X-ray wayeyi-Cu-Kα I-scan angle isuka ku-0 ° kuya ku-80 ° (2θ). Ukuskena isivinini 6 ° / min.

2.2.3.2 Izakhiwo zemishini

Amandla asheshayo kanye nokubumbana ekwephuleni kwefilimu kusetshenziswa njengemibandela yokwahlulela izakhiwo zayo zemishini, namandla ashubile (amandla ashukumisayo) kubhekisa ekucindezelweni kwepulasitiki okuphezulu, kanti iyunithi ikhiqiza i-MPA ephezulu yepulasitiki, kanye neyunithi yi-MPA. I-Elongation ekhefu (ukwephula i-elongation) isho isilinganiso se-elongation lapho ifilimu iphukile kubude bokuqala, kuvezwe ku-%. Uhlobo lwe-Instron (5943) Uhlobo lwe-Electronic Universal Inval Instrate Machine of Instrun (Shanghai) imishini yokuhlola, ngokusho kwendlela yokuhlola ye-GB13022-92 yezindawo ezi-25 ° C, ukhetha amasampula ngobukhulu obungenamfaniswano kanye nokungcola komhlaba kuyahlolwa.

2.2.3.3 Izakhiwo ze-Optical

Izakhiwo ze-Optical ziyinkomba ebalulekile yokubonakala kwamafilimu okupakisha, ikakhulukazi kufaka phakathi ukudluliselwa kanye ne-haze yefilimu. Ukudluliselwa kanye neHaze lamafilimu alinganiswa kusetshenziswa umhloli we-haze transmitance. Khetha isampula yokuhlola enobuthi obuhlanzekile futhi akukho okungaqaleki, bawubeke ngobumnene endaweni yokuhlola, bayilungise ngendebe yokuhlola, bese ulinganisa ukudluliselwa kokukhanya, bese ukala ukudluliselwa kokukhanya kanye ne-haze yefilimu ekushiseni kwegumbi (25 ° C no-50% RH). Isampula ihlolwe amahlandla ama-3 nenani eliphakathi lithathiwe.

2.2.3.4 I-solubity yamanzi

Sika ifilimu elingu-30mm × 30mm elinobukhulu obungama-45μM, engeza ama-100ml wamanzi ku-weaker engu-200ml, beka ifilimu maphakathi nendawo yamanzi, bese ukala isikhathi sefilimu ukuba inyamalale ngokuphelele [56]. Isampula ngayinye yalinganiswa amahlandla ama-3 kanti inani elijwayelekile lathathwa, futhi iyunithi laliyimin.

2.2.4 Ukucutshungulwa kwedatha

Idatha yokuhlola yacutshungulwa yi-Excel futhi yahlelwa nge-software yemvelaphi.

2.3 Imiphumela Nengxoxo

2.3.1.1 amaphethini we-XRD amafilimu amancanyana we-HPMC ngaphansi kokugxila kwezixazululo ezahlukene zefilimu

I-Fig.2.1 xrd yamafilimu we-HPMC ngaphansi kokuqukethwe okuhlukile kwe-HP

I-Dide-Angle X-RAY TRIFTRACTION ukucubungula kwesimo se-crystalline yezinto ezingeni lamangqamuzana. Umdwebo 2.1 yiphethini yokuphazamiseka kwe-XRD yamafilimu amancanyana e-HPMC ngaphansi kokugxila kwesisombululo esihlukile sefilimu. Kuneziqongo ezimbili zokuphazamiseka [57-59] (eduze kuka-9.5 ° no-20.4 °) kwifilimu ye-HPMC esithombeni. Kungabonakala kulokho okuvela ekukhulisweni kwe-HPMC okuhlushwa, iziqongo ezihlukile zefilimu ye-HPMC ezungeze u-9.5 ° no-20.4 ° zithuthukiswa okokuqala. bese kuba buthaka, izinga lokuhlelwa kwamangqamuzana (ukuhlelwa okuyaliwe) kwanda kuqala bese kwehla. Lapho okuhlushwa kungu-5%, ukuhleleka okuhlelekile kwama-molecule we-HPMC akulungele. Isizathu sokuthi le nto engenhla kungenzeka ukuthi ngokwanda kokuhlushwa kwe-HPMC, inani le-crystal nuclei kukhambi elakha amafilimu liyakhuphuka, ngaleyo ndlela lenze ilungiselelo le-HPM molecular. Lapho ukugxila kwe-HPMC kudlula i-5%, i-XRD DifTraction Peak yefilimu iyakhononda. Kusukela endaweni yokubuka ama-molecular chain ukuhlela, lapho ukugxila kwe-HPMC kukhulu kakhulu, i-viscosity yekhambi elakha amafilimu liphezulu kakhulu, okwenza kube nzima ngamaketanga ama-molelisar ukunyakaza futhi akwazi ukuhlelwa ngesikhathi samafilimu we-HPMC ancipha.

2.3.1.2 Izakhiwo zemishini zamafilimu amancane we-HPMC ngaphansi kokugxila kwezixazululo ezahlukene zefilimu.

Amandla asheshayo kanye nokubumbana lapho kwephuka ifilimu kusetshenziswa njengezindlela zokwahlulela izakhiwo zalo zemishini, futhi amandla ashubile abhekisele ekucindezelweni lapho i-deform yepulasitiki ephezulu kakhulu. I-elongation ekhefu iyisilinganiso sokufuduka kwabasekuqaleni kwefilimu ekhefu. Ukulinganiswa kwezindawo zemishini yefilimu kungahlulela ukusetshenziswa kwayo kwamanye amasimu.

Fig.2.2 Umphumela wokuqukethwe okuhlukile kwe-HPMC ngezindawo zemishini yamafilimu we-HPMC

Kusuka ku-Fig. 2.2, umkhuba oguqukayo wamandla ashukumisayo kanye nokubumbana ekwephuzele ifilimu le-HPMC ngaphansi kokugxila kwefilimu, kungabonakala ukuthi amandla e-HPMC akhuphuka ngokuhlushwa kwesixazululo sefilimu ye-HPMC. Lapho ukugxila kwesixazululo kungu-5%, izakhiwo zemishini zamafilimu we-HPMC zingcono. Lokhu kungenxa yokuthi lapho ukuqunjelwa koketshezi okwenziwe ngefilimu kuphansi, isixazululo sokuphambuka siphansi, ukuxhumana phakathi kwamaketanga ama-molecular kubuthakathaka, ngakho-ke ama-molecule awakwazi ukuhlelwa ngendlela ehlelekile, ngakho-ke amandla e-crystallization wefilimu aphansi futhi izici zalo zemishini zimpofu; Lapho ukuhlushwa kwe-liquid ekwakheka ifilimu kungu-5%, izakhiwo zemishini zifinyelela inani elikhulu; Njengoba ukugcwaliswa koketshezi ekwakheka amafilimu kuyaqhubeka ukwanda, ukusakaza kanye nokuxhashazwa kwekhambi kube nzima ngokwengeziwe, okuholela ekunciphiseni amafilimu we-HPMC atholakele kanye nama-60], okuholela ekunciphiseni kwezindawo zamafilimu we-HPMC. Ngakho-ke, ukugcwaliseka kwe-5% HPMC ekwakheni ngefilimu ekwakheka ifilimu kufanelekile kakhulu. Ukusebenza kwefilimu etholakele nakho kungcono.

2.3.1.3 Izakhiwo ze-Optical zamafilimu amancane we-HPMC ngaphansi kokugxila kwezixazululo ezahlukene zefilimu

Emafilimu okupakisha, ukudluliselwa okukhanyayo kanye ne-haze amapharamitha abalulekile akhombisa ukucaca kwefilimu. Umdwebo ongu-2 Kungabonakala kusuka kuMdwebo wokuthi ngokwanda kwesisombululo sefilimu ye-HPMC, ukudluliselwa kwefilimu ye-HPMC kancane kwehla kancane kancane, futhi i-Haze inyuke kakhulu ngokwanda kwesisombululo esakha amafilimu.

I-Fig.2.3 Umphumela wokuqukethwe okuhlukile kwe-HPMC empahleni ebonakalayo yamafilimu we-HPMC

Kunezizathu ezimbili eziyinhloko: Okokuqala, kusukela ekubukeni kwenombolo yenombolo yesigaba esihlakazekile, lapho okuhlushwa kuphansi, okuhlushwa izinombolo kunomphumela ovelele ezindaweni ezibonakalayo ze- [61]. Ngakho-ke, ngokwanda kokuqoqwa kwesixazululo esakha amafilimu se-HPMC, izinqumo zefilimu ziyancishiswa. Ukudluliselwa kokukhanya kwehle kakhulu, futhi i-Haze inyuke kakhulu. Okwesibili, kusukela ekuhlaziyweni kwenqubo yokwenza amafilimu, kungaba yingoba ifilimu yenziwa yisisombululo esichitha indlela eyakha amafilimu. Ukwanda kobunzima bokunwebeka kuholela ekunciphiseni ubushelelezi bendawo yefilimu nokuncipha kwezindawo zefilimu ye-HPMC.

2.3.1.4 I-solubility yamanzi yamafilimu amancanyana e-HPMC ngaphansi kokugxila okuhlukile kwefilimu

I-solubility yamanzi yamafilimu ancibilikayo amanzi ahlobene nokuhlushwa kwawo kwefilimu. Sika amafilimu angama-30mm × 30mm enziwe ngefilimu ehlukile eyakha ukugxila, bese umaka ifilimu nge "+" ukukala isikhathi sefilimu ukuba inyamalale ngokuphelele. Uma ifilimu emboza noma inamathela ezindongeni ze-beaker, ushede. Umdwebo ongu-2.4 ngumdwebo womthamo we-solubility yamanzi yamafilimu we-HPMC ngaphansi kokugxila okuhlukile kwefilimu. Kungabonakala kusuka kuMdwebo wokuthi ngokwanda kokuhlushwa okungamampunge kwefilimu, isikhathi esinyibilikayo samanzi samafilimu we-HPMC eba isikhathi eside, okukhombisa ukuthi i-solubity yamanzi yamafilimu we-HPMC iyancipha. Kucatshangelwa ukuthi isizathu kungenzeka ukuthi ngokwanda kwesixazululo sokwakha amafilimu we-HPMC, ukubonwa kwesixazululo kuyanda, okuholela ekunciphiseni ifilimu le-HPMC emanzini kanye nokuncipha kwe-solubity yamanzi.

I-Fig.2.4 Umphumela wokuqukethwe okuhlukile kwe-HPMC kuma-solubity amanzi amafilimu we-HPMC

2.3.2 Umphumela wokushisa kwemithi yefilimu kumafilimu amancane we-HPMC

2.3.2.1 Amaphethini we-XRD amafilimu amancanyana e-HPMC kumazinga ehlukene amazinga okushisa ahlukahlukene

I-Fig.2.5 XRD yamafilimu we-HPMC ngaphansi kokushisa okuhlukile kwefilimu

Umdwebo ongu-2,5 ukhombisa amaphethini we-XRD amafilimu amancane we-HPMC kumafuzo ahlukene okwakha amazinga okushisa. Iziqongo ezimbili zokuphazamiseka ngo-9.5 ° no-20.4 ° zahlaziywa ngefilimu le-HPMC. Ngokombono wokuqina kweziqongo ezihlukile, ngokwanda kwamazinga okushisa akha amafilimu, iziqongo eziphakeme ezindaweni ezimbili zanda okokuqala bese zihle zincipha, bese kuthi amakhono e-crystallization aqala ukwehla. Lapho amazinga okushisa akha amafilimu ayengu-50 ° C, amalungiselelo awo awokuyalwa kwama-molecule we-HPMC ngokubuka komphumela wokushisa kwe-nucleaus, lapho izinga lokuvundwa liphezulu, izinga lokukhula kwe-crystal nuclei lincane, futhi i-crystallization inzima; Njengoba izinga lokushisa lefilimu elikhuphuka kancane kancane likhula, isilinganiso sokukhuphuka kwe-nucleculation, ukunyakaza kwe-molecular chain kusheshiswa kalula, futhi kulula ukwakha i-crystallization, ngakho-ke i-crystallization izofinyelela inani eliphakeme ekushiseni okuthile; Uma izinga lokushisa lefilimu liphezulu kakhulu, ukunyakaza kwamangqamuzana kunzima kakhulu, ukwakheka kwe-crystal nucleus kunzima, futhi ukwakheka kokusebenza kahle kwenuzi kuphansi futhi kunzima ukwakha amakristalu [62,63]. Ngakho-ke, i-Crystaltaltity yamafilimu we-HPMC akhuphuka kuqala abese encipha ngokwanda kwamazinga okushisa akha amafilimu.

2.3.2.

Ukushintshwa kwamazinga okushisa akha amafulethi kuzoba nethonya elithile lethonya ezingxenyeni zemishini yefilimu. Umdwebo ongu-2.6 ukhombisa ukuthambekela okuguqukayo kwamandla ashukumisayo kanye nokubumbana ekwephuleni kwamafilimu we-HPMC kumafilimu ahlukene okwakha amazinga okushisa ahlukene. Ngasikhathi sinye, kwabonisa umkhuba wokwanda kokuqala bese kuncipha. Lapho ifilimu eyakha izinga lokushisa lalingu-50 ° C, amandla asheshayo kanye nokubumbana ekwephuleni kwefilimu le-HPMC kufinyelelwe amanani aphezulu, okwakungama-116 MPA kanye nama-32%, ngokulandelana.

I-Fig.2.6 Umphumela wokushisa kwefilimu okwenziwe ngezindawo zemishini yamafilimu we-HPMC

Ngokombono wokuhleleka kwamamolekyur, kukhulu ukuhleleka okuhlelekile kwama-molekyuli, okungcono amandla ashubile [64]. Kusuka ku-Fig. 2.5 Amaphethini we-XRD wamafilimu we-HPMC kumazinga okushisa ahlukene eformani, kungabonakala ukuthi ngokwanda kokushisa kwemithi yefilimu, ukuhleleka okuhleliwe kwama-molecule we-HPMC akhula kuqala bese kuncipha. Lapho izinga lokushisa lefilimu lefilimu lingu-50 ° C, izinga lokuhlelwa oku-odwayo liyindawo enkulu kunazo zonke, ngakho-ke amandla ashubile amafilimu we-HPMC akhula kuqala bese encipha ngokwanda kwamazinga okushisa akha amafilimu angu-50 ℃. Ukugcwala ekhefu kukhombisa umkhuba wokwanda kokuqala bese kuncipha. Isizathu kungenzeka ukuthi ngokwanda kwamazinga okushisa, ukuhleleka okuhlelekile kwama-molecule okuqala kwandisiwe bese kuncipha, futhi isakhiwo se-crystalline esakhiwe e-polymer matrix kuhlakazeka ku-matrix ye-polymer. E-matrix, kwakhiwa isakhiwo esixhumeke ngokomzimba, esidlala indima ethile ekutholeni [okungu-65], ngaleyo ndlela kukhuthaza ukugcwala kwefilimu le-HPMC ukuze kubonakale inani eliphakeme ekushiseni kokwakheka kwamafilimu okungu-50 ° C.

2.3.2.3 Izakhiwo ze-Optical zamafilimu we-HPMC emafulethini ahlukene okwakha amazinga okushisa

Umdwebo ongu-2.7 uyi-Cloge Curve yezakhiwo ze-Optical zamafilimu we-HPMC kumafilimu ahlukene akha amazinga okushisa. Kungabonakala kusuka kuMdwebo wokuthi ngokwanda kwamazinga okushisa akha amafilimu, ukudluliselwa kwefilimu le-HPMC kancane kancane, kancane kancane i-Haze iyancipha, futhi izakhiwo ze-hpmc kancane kancane ziba ngcono kancane kancane.

I-Fig.2.7 Umphumela wokushisa kwefilimu okwenziwe ngempahla ebonakalayo ye-HPMC

Ngokusho kwethonya lokushisa nama-molecule wamanzi kwifilimu [66], lapho amazinga okushisa aphansi, ama-molecule wamanzi akhona ku-HPMC ngesimo samanzi aboshwe, kepha amanzi aboshwe azokwenza kancane kancane, futhi i-HPMC isesimweni sengilazi. Ukuthambekela komoya wefilimu kwakha izimbobo ku-HPMC, bese kusabalalisa ukwakheka ezimbobo ngemuva kokunganaki okukhanyayo [67], ngakho-ke ukukhanya kwefilimu kuphansi futhi iHaze iphakeme; Njengoba izinga lokushisa likhuphuka, izingxenye zamangqamuzana ze-HPMC ziqala ukunyakaza, izimbobo zakhiwa ngemuva kokugcwala kwamanzi okuguqukayo, izimbobo zokusakaza kancane kancane, ukudluliselwa kancane [68], ngakho-ke kukhuphuka kancane [68], ngakho-ke kuncipha ukudluliswa kwefilimu.

2.3.2.4 I-solubity yamanzi yamafilimu we-HPMC kumafutho ahlukene abumba amazinga okushisa

Umdwebo ongu-2.8 ukhombisa ama-curve wamanzi we-solubity amafilimu we-HPMC kumafuzo ahlukene okwakha amazinga okushisa. Kungabonakala esimweni sokuthi isikhathi se-solubity samanzi sanda ngokwanda kwamazinga okushisa akha amafilimu, okungukuthi, ukugcwala kwamanzi kwamafilimu we-HPMC kuba kubi kakhulu. Ngokunyuka kwamazinga okushisa akha amafilimu, izinga lokuhwamuka kwama-molekyuli amanzi kanye ne-gelation asheshisiwe, ukunyakaza kwamaketanga ama-molecular kuyasheshiswa, futhi ukuhlelwa kwamangqamuzana kuncishisiwe, futhi ukuhlelwa kwamangqamuzana kuyancipha, okwenza kube nzima kuma-molecule wamanzi. I-solubity yamanzi nayo iyancishiswa.

Fig.2.8 Umphumela wokushisa kwefilimu okwenziwayo kuma-solubility amanzi efilimu le-HPMC

2.4 Isifinyezo salesi sahluko

Kulesi sahluko, i-hydroxypropyllykyl isetshenziswe njengento eluhlaza ukulungiselela amafilimu we-HPMC ancibilikisa amanzi ngesixazululo sokuphonsa indlela eyakha amafilimu. I-Crystallity yefilimu ye-HPMC yahlaziywa nge-XRD Difraction; Izakhiwo zemishini zefilimu yokufaka amanzi e-HPMC zihlolwe futhi zahlaziywa ngumshini wokuhlola we-Micro-elekthronikhi we-Tensile we-Tensile, futhi izakhiwo zefilimu ye-HPMC zihlaziywa yi-Light Transfer Tester. Isikhathi sokuchithwa emanzini (isikhathi samanzi se-solubicility) sisetshenziselwa ukuhlaziya ukuhlaziya amanzi aso. Iziphetho ezilandelayo zidonswa kulolu cwaningo olungenhla:

1) Izakhiwo zemishini zamafilimu we-HPMC akhuphuke kuqala bese wehla ngokwanda kokuqothuka kwesixazululo esakha amafilimu, futhi okokuqala kwancipha bese kwehla ngokwanda kwamazinga okushisa akha amafilimu. Lapho ukugcwala kwekhambi le-HPMC ekwakha amafilimu kwakungu-5% futhi izinga lokushisa elakha amafilimu lalingu-50 ° C, izakhiwo zemishini zefilimu zilungile. Ngalesi sikhathi, amandla ashukumisayo acishe abe ngu-116MPA, futhi ukugcwala ekhefu cishe ngo-31%;

2) Izici ze-Optical zamafilimu we-HPMC ancipha ngokunyuka kokuqoqwa kwesixazululo esakha amafilimu, futhi kancane kancane kwanda ngokwanda kwamazinga okushisa akha amafilimu; Ngokuphelele Ukuthi ukugcwaliswa kwesixazululo esakha amafilimu akufanele kudlule ama-5%, futhi izinga lokushisa elakha amafilimu akufanele lidlule ku-50 ° C

3) Amanzi we-solubility amafilimu we-HPMC akhombisa ukuthambekela okungezansi ngokunyuka kokuhlushwa kwesixazululo esakha amafilimu kanye nokwanda kokushisa kwefilimu. Lapho kusetshenziswa isixazululo se-5% hpmc yefilimu i-5% kanye namazinga okushisa akha amafilimu angu-50 ° C.

Isahluko 3 Imiphumela yamapulasitiki kumafilimu wokupakisha wamanzi we-HPMC

3.1 Isingeniso

Njengohlobo olusha lwe-polymer materecc mater-seluble packing filfilimu inethemba elihle lokuthuthuka. I-Hydroxypropyll methylcellulose iyinhlangano etholwa yimvelo yemvelo. Akulona ubuthi, kungangcolisi, okuvuselelekayo, okuzinzile ngamakhemikhali, futhi kunezakhiwo ezinhle. Ukuncibilika kwamanzi futhi kwakha amafilimu, kuyizinto ezisetshenziselwa amafilimu ezingenamanzi.

Isahluko esedlule saxoxa ngokulungiswa kwe-HPMC EXS-BAMEble Packing Flualing Film ngokusebenzisa i-hydroxypropyll methylcellulose njengezinto ezisetshenziswayo ezisetshenziswayo nge-hydroxypropyll methylcellulose methylcellulose amafilimu wamanzi angenamanzi. Umthelela Wokusebenza. Imiphumela ikhombisa ukuthi amandla ashubile wefilimu acishe abe ngu-116MPA futhi ukugcwala ekhefu kungu-31% ngaphansi kwezindlela ezinhle zokuhlushwa kanye nezimo zenqubo. Ukuqina kwamafilimu anjalo ampofu kwezinye izinhlelo zokusebenza futhi kudinga ukuthuthuka okwengeziwe.

Kulesi sahluko, i-hydroxypropyllylylylyls isetshenziswa njengento eluhlaza, kanti ifilimu yokufaka amanzi ilungiswa ngesisombululo sokuphonsa indlela eyakha amafilimu. , ukugcwala ekhefu), izakhiwo ze-Optical (Transmitance, Haze) kanye ne-solubity yamanzi.

3.2 UMnyango Wezokuhlola

3.2.1 izinto zokuhlola nezinsimbi

Ithebula 3.1 Izinto zokuhlola kanye nokucaciswa

Ithebula 3.2 Amathuluzi okuhlola nokucaciswa

3.2.2 Ukulungiswa kwesampula

1) Isisindo: Linganisa inani elithile le-hydroxypropyllyrproses (5%) ne-sorbibitol (0.05%, 0.05%, 0.05%, 0.05%, 0.05%) nge-0.05%, 0.45%, 0.45%).

2) Ukuchithwa: Faka isisindo se-hydroxypropyll methylcellulose ngamanzi alungiselelwe alungiselelwe, uvuse ekushiseni okujwayelekile kanye nengcindezi kuze kube yilapho ichithiwe ngokuphelele, bese wengeza i-glycerol noma i-sorbibittol ezingxekeni ezihlukene eziningi ngokulandelana. Esixazululweni se-hydroxyproppropyl methylcellulose, uvuse isikhathi esithile ukuyenza ixutshwe ngokulinganayo, futhi iyeke ime imizuzu emi-5 (defouming) ukuthola ukugxila okuthile koketshezi ekwakheka ifilimu.

3) Ukwenza Kwefilimu: Faka uketshezi olwakha amafilimu esitsheni se-petri esilazi bese usiphonsa ukuze wakhe ifilimu, makame isikhathi esithile sokuyenza i-gel, bese uyibeka kwifilimu ukwenza ifilimu ngokukhulu kuka-45 μm. Ngemuva kokuthi ifilimu ibekwe ebhokisini lokomisa ukuze lisetshenziswe.

3.2.3 Isimo nokuhlolwa kokusebenza

3.2.3.1 Ukuhlaziywa kwe-spectroscopy (i-FT-IR)

I-infrared amunction Spectroscopy (FTIR) iyindlela enamandla yokubonisa amaqembu asebenzayo aqukethe ekwakhekeni kwamangqamuzana nokuhlonza amaqembu asebenzayo. I-infrared insurption spectrum yefilimu yokupakisha ye-HPMC yalinganiswa kusetshenziswa i-nicolet 5700 Fourier Transform Infrared Spectrometer ekhiqizwe yi-Thermoelectric Corporation. Indlela yefilimu emincane yasetshenziswa kulolu vivinyo, i-Scanning Range ibingu-500-4000 cm-1, kanti inani lokuskena lalingu-32. Amafilimu ayisampula awomile e-ORPREDROScopy.

3.2.3.2 Ububanzi bokuhlaziywa kwe-X-ray

3.2.3.3 Ukunqunywa kwezimpahla zemishini

Amandla asheshayo kanye nokubumbana lapho kwephuka ifilimu kusetshenziswa njengemingcele yokwahlulela izakhiwo zayo zemishini. I-elongation ekhefu iyisilinganiso sokufuduka kobude bokuqala lapho ifilimu iphukile, ku-%. Usebenzisa i-Instron (5943) miniature umshini wokuhlola wokuhlola we-Instrunive Universal of Instrun (Shanghai), ngokuya nge-GB1302-92 Indlela yokuhlola ye-Tensaile yamafilimu epulasitiki, avivinyeka ngo-25 ° C, amasampula anobukhulu obungahloliwe.

3.2.3.4 Ukunqunywa Kwezakhiwo Zamehlo: Kuyafana ne-2.2.3.3

3.2.3.5 Ukunqunywa kwamanzi nge-solubity

Sika ifilimu elingu-30mm × 30mm elinobukhulu obungama-45μM, engeza ama-100ml wamanzi ku-weaker engu-200ml, beka ifilimu maphakathi nendawo yamanzi, bese ukala isikhathi sefilimu ukuba inyamalale ngokuphelele [56]. Isampula ngayinye yalinganiswa amahlandla ama-3 kanti inani elijwayelekile lathathwa, futhi iyunithi laliyimin.

3.2.4 Ukucutshungulwa kwedatha

Idatha yokuhlola yacutshungulwa yi-Excel, futhi igrafu yadonswa isoftware yemvelaphi.

3.3 Imiphumela Nengxoxo

3.3.1 imiphumela ye-glycerol ne-sorbibitlol ku-infrared amunction Spectrum yamafilimu we-HPMC

(a) glycerol (b) i-sorbibitol

I-Fig.3.1 FT-IR yamafilimu we-HPMC ngaphansi kwe-Glycerol ehlukile noma i-Sorbibolum Concentrat

I-infrared amunction Spectroscopy (FTIR) iyindlela enamandla yokubonisa amaqembu asebenzayo aqukethe ekwakhekeni kwamangqamuzana nokuhlonza amaqembu asebenzayo. Umdwebo 3.1 ukhombisa ukubonwa okungenankinga kwamafilimu we-HPMC anengezelwa e-Glycerol ehlukile ne-Sorbittol. Kungabonakala esifanekisweni sokuthi iziqongo ze-skeleton vibration peats zamafilimu we-HPMC ikakhulukazi ezifundeni ezimbili: 2600 ~ 3700cm-1 no-750 ~ 1700cm-1 [5718cm-1

Ama-band aseduze amuncwabibangelwa ukudlidliza okwenziwe nge-oh bond, 2935cm-1 yinto ephakeme ye--CH2, 1050cm-1 yindawo ephakeme ye-hydroxyl, kanye ne-1657cm Inani eliphakeme le-Hydroxyl Group eqenjini le-hydroxyl ekwehleni kokudlidliza kohlaka, i-945cm-1 yi-rokazi amuncy tok of -c3 [69]. Iziqongo zokumuncwa ngo-1454cm-1, 1373CM-1, 1315CM-1, 1315CM-1 no-945cm-1 zabelwa ukunyakaza kwe-asymmetric, ukudlidliza kwe-symmetrical, endizeni nasezindizeni enobangelwa yi-9]. Ngemuva kwepulasitiki, azikho iziqongo ezintsha ezivele zivele kwi-infrared depyrum yefilimu, okukhombisa ukuthi i-HPMC ayizange ithole ushintsho olubalulekile, okungukuthi, ipulasitiki ayizange ichithe isakhiwo sayo. Ngokungezwa kwe-glycerol, inani eliphakeme lokudlidliza -Oh ku-3418cm-1 lefilimu le-HPMC elibuthakathaka, kanye nenani eliphakeme ngo-1657cm-1, amaqembu amuncu abuthaka, kanye namaqembu amunwe abuthaka, kanye namaqembu amuncu abuthakathaka abuthaka; Ngokungezwa kwe-Sorbibibit kwifilimu ye-HPMC, iziqongo zokudlidliza ze-The -Oh ku-3418cm-1 zibuthakathaka, kanye neziqongo zokutholwa ku-1657cm-1 zibuthakathaka. . Izinguquko zalezi zingxenye zokuhlonza zibangelwa yimiphumela ebabazekayo kanye nokubopha ama-hydrogen nge-hydrogen, okubenza bashintshe ngamabhendi aseduze -Ch3 no -ch2. Ngenxa yokuncane, ukufakwa kwezinto ezingama-molecular kuvimbela ukwakheka kwama-hymolecular hydrogen bond, ngakho-ke amandla ashubile efilimu elihlanganisiwe ancipha [70].

3.3.2 Imiphumela ye-Glycerol ne-Sorbibittol kumaphethini we-XRD amafilimu we-HPMC

(a) glycerol (b) i-sorbibitol

I-Fig.3.2 xrd yamafilimu we-HPMC ngaphansi kwe-glycerol ehlukile noma i-sorbitolum excracra

I-Wide-Angle X-RAY TAGRACTION (XRD) ihlaziya isimo se-crystalline yezinto ezingeni lamangqamuzana. I-x-ray diffractometer ye-arl / xtra uhlobo olukhiqizwe yi-Thermo Arl inkampani eSwitzerland yasetshenziselwa ukuzimisela. Umdwebo 3.2 yiphethini le-XRD lamafilimu we-HPMC anengezelwe ahlukile e-Glycerol ne-SorbibibitoL. Ngokungezwa kwe-glycerol, ubukhulu beziqongo eziphakeme ngo-9.5 ° no-20.4 ° bobabili buthaka; Ngokungezwa kwe-SORBOLOL, lapho inani lokungeza lalingu-0.15%, i-Diftaction Peak ku-9.5 ° yathuthukiswa, kepha inani eliphakeme libe buthaka, kepha inani eliphakeme kakhulu lefilimu le-HPMC laliphansi kwe-SORBITOL. Ngokungezwa okuqhubekayo kwe-SORBOLOL, i-Diftaction Peak ngo-9.5 Lokhu kungenxa yokuthi ukungezwa kwama-molecule amancane e-glycerol kanye ne-sorbitlol kuphazamisa ukuhleleka okuhlelekile kwamaketanga ama-molecular futhi kubhubhise isakhiwo sekristalu sokuqala, ngaleyo ndlela kunciphisa ukukristalu kwefilimu. Kungabonakala kusuka kumuntu i-Glycerol inethonya elikhulu ekuthuthukisweni kwamafilimu we-HPMC, okukhombisa ukuthi i-Glycerol ne-HPMC banokuhambisana okuhle, ngenkathi i-SORBITOL ne-HPMC benokufaneleka okungafanele. Ukusuka ekuhlaziyeni kwezokwakheni kwamapulasitiki, i-Sorbibibitol inesakhiwo soshukela esifana naleso se-cellulose, futhi umphumela wakubokuphazamiseka wayo mkhulu, okuholela ekuhlanganyeleni okubuthakathaka phakathi kwama-molecule we-sorbitol kanye ne-cellulose molecule, ngakho-ke kunomthelela omncane kwi-cellulose crystallization.

[48].

3.3.3 Imiphumela ye-glycerol ne-sorbittol ezindaweni ezisebenza ngemishini yamafilimu we-HPMC

Amandla asheshayo kanye nokubumbana lapho kwephuka ifilimu kusetshenziswa njengamapharamitha ukwahlulela izakhiwo zawo zemishini, futhi ukukala kwezindawo zemishini kungahlulela ukusetshenziswa kwayo emikhakheni ethile. Umdwebo 3.3 ukhombisa ushintsho kumandla ashukumisayo kanye nokubumbana ekwephuleni kwamafilimu we-HPMC ngemuva kokungeza amapulasitiki.

Umdwebo

Kungabonakala kusuka kuMdwebo 3.3 (a) ukuthi ngokungezwa kwe-glycerol, ukugcwala kwefilimu ye-HPMC kukhula kuqala bese kuncipha, lapho amandla ashubayo aqala ukuncipha ngokushesha, khona-ke akhuphuka kancane bese eqhubeka nokuncipha. I-elongation ekhefu lefilimu le-HPMC lenyuka okokuqala bese lincipha, ngoba i-glycerol inamaqembu amaningi we-hydrophilic, okwenza ama-molecule angokwengeziwe namanzi anomphumela we-hydration oqinile [71], ngaleyo ndlela ethuthukisa ukuguquguquka kwefilimu. Ngokunyuka okuqhubekayo kokungezelelwa kwe-glycerol, ukugcwala kwefilimu ye-HPMC kuyancipha, ngoba i-glycerol yenza igebe le-mecMc likhuphuke, futhi ifilimu lithambekele ekuphumeni, ngaleyo ndlela lehlile lapho kuncipha lapho kuncishiswa khona ifilimu. Isizathu sokuncipha okusheshayo kwamandla ashukumisayo yile: Ukungezwa kwama-molecule amancane e-Glycerol kuphazamisa ukuhlelwa kwamaketanga ama-HPMC, kwehlisa amandla okusebenzisana phakathi kwe-macromolecule, futhi kunciphise amandla ashubile efilimu; amandla ashubile akhuphuka amancane, ngokombono wamalungiselelo okulandela ama-molecular, i-glycerol efanelekile inyusa ukuguquguquka kwamaketanga ama-molefanel avumelana nezinga elithile, futhi enza amandla ashukumisayo enyuka kancane; Kodwa-ke, lapho kune-glycerol eningi kakhulu, amaketanga ama-molecular ahlelwe ngasikhathi sinye njengelungiselelo elihlelekile, kanti izinga lokuhleleka liphakeme kunaleso salolo lungiselelo [72], elinciphisa amandla aphansi wefilimu le-HPMC. Njengoba umphumela oshukumisayo ungasebenzi amandla ashubile efilimu le-HPMC, inani le-Glycerol elingeziwe akufanele libe likhulu kakhulu.

Njengoba kukhonjisiwe kuMdwebo 3.3 (B), ngokufakwa kwe-Sorbibibibit, ukugcwala kwefilimu ye-HPMC kukhula okokuqala kwabe sekuncipha. Lapho inani le-sorbibitl lalingu-0.15%, ukugcwala ekwephuleni kwefilimu le-HPMC kufinyelelwe ama-45%, bese kuba khona ukunwebeka ekwephuzele kancane kancane. Amandla ashubeni ancipha ngokushesha, bese eshintsha azungeze ama-50MP ngokungezwa okuqhubekayo kwe-sorbibibibibittol eqhubekayo. Kungabonakala ukuthi lapho inani le-sorbibitlol elingeziwe lingu-0.15%, umphumela weplastiki ungcono kakhulu. Lokhu kungenxa yokuthi ukungezwa kwama-molecule amancane we-sorbitol kuphazamisa ukuhlelwa kwamaketanga amamolekyuli, okwenza igebe phakathi kwama-molecule likhudlwana, amandla okusebenzisana ancishisiwe, ngakho-ke ama-molecule alula ukuslayida, ngakho-ke ama-molecule alula ukushelela, ngakho-ke ukugcwala kwesephukile kwefilimu kukhuphuka kanye nokwehla kwamafilimu. Njengoba inani le-sorbibitolol laqhubeka likhuphuka, ukugcwala kwekhefu lefilimu kuncishisiwe futhi, ngoba amamolekyuli amancane e-sorbibitol ayesatshalaliswa ngokugcwele phakathi kwama-macromolecule, aphumela ekunciphiseni kancane kancane kwama-macromolecule phakathi kwama-macromolecule phakathi kwama-macromolecule kanye nokuncipha kokunwebeka ekwephulweni kwefilimu.

Qhathanisa imiphumela yepulasitiki ye-glycerol ne-sorbittol kumafilimu we-HPMC, engeza i-0.15% Glycel ingakhuphula ukunwebeka ekwephuleni kwefilimu cishe ngo-50%; Ngenkathi ungeza i-0.15% Sorbibibitlol angakhulisa kuphela ukunwebeka lapho kufinyelela khona ifilimu elifinyelela cishe ku-45%. Amandla ashubile anciphile, futhi ukwehla kwakukuncane lapho kufakwa i-glycerol. Kungabonakala ukuthi umphumela weplastiya we-glycerol kwifilimu ye-HPMC ungcono kunalokho kwe-sorbibittol.

3.3.4 Imiphumela ye-glycerol ne-sorbittol ezindaweni ezibonakalayo zamafilimu we-HPMC

(a) glycerol (b) i-sorbibitol

I-Fig.3.4 Umphumela we-glycerol noma i-sorbitolumon optical impahla yamafilimu we-HPMC

Ukudluliselwa okukhanyayo kanye neHaze amapharamitha abalulekile wokubonakala kwefilimu yokupakisha. Ukubonakala nokucaciswa kwezimpahla ezihlanganisiwe kuncike ekuthandeni okukhanyayo kanye ne-haze yefilimu yokufaka. Njengoba kukhonjisiwe kuMdwebo 3.4, ukungezwa kwe-Glycerol ne-Sorbibitho bobabili kwathinta izakhiwo ze-Optical zamafilimu we-HPMC, ikakhulukazi. Umdwebo 3.4 (a) uyigrafu ekhombisa umphumela wesengezo se-Glycerol ezingxenyeni zokubona zamafilimu we-HPMC. Ngokungezwa kwe-glycerol, ukudluliselwa kwamafilimu we-HPMC akhuphuke okokuqala bese ancipha, afinyelela inani eliphakeme eliphakeme ngo-0.25%; I-Haze inyuke ngokushesha futhi kancane kancane. Kungabonakala ekuhlaziyeni okungenhla ukuthi lapho inani lokungezwa kwe-glycerol lingu-0.25%, izakhiwo zefilimu zingcono, ngakho-ke inani le-glycerol akufanele lidlule ku-0.25%. Umdwebo 3.4 (b) uyigrafu ekhombisa umphumela we-Sorbittol ukwengezwa kwezindawo ezibonakalayo zamafilimu we-HPMC. Kungabonakala kusuka kuMdwebo wokuthi ngokungezwa kwe-Sorbibibit, amafilimu we-HPMC akhuphuka kuqala, khona-ke kuncipha kancane bese kukhuphuka, futhi ukudluliswa kwandisiwe kuqala bese kukhuphuka. Kwehle, futhi ukudluliselwa kokukhanya kanye noHaze kwavela iziqongo ngasikhathi sinye lapho inani le-sorbibibing lalingu-0.45%. Kungabonakala ukuthi lapho inani le-sorbitlol elingeziwe liphakathi kuka-0.35 no-0.45%, izakhiwo zalo zokukhanya zingcono. Ukuqhathanisa imiphumela ye-glycerol ne-sorbittol ezindaweni ezibonakalayo zamafilimu we-HPMC, kungabonakala ukuthi i-sorbibibibibithol inomthelela omncane kwizakhiwo ze-optical zamafilimu.

Ngokuvamile ukukhuluma, izinto zokwakha ezinokuhanjiswa okuphezulu zizoba ne-haze ephansi, futhi okuphambene nalokho, kepha akunjalo njalo. Ezinye izinto zokwakha zinokudluliselwa okuphezulu okukhanyayo kepha futhi namanani aphezulu we-haze, njengamafilimu amancanyana afana nengilazi enesiqhwaga [73]. Ifilimu elungiselelwe kulolu vivinyo ingakhetha i-Plistic efanelekile nenani lokungezwa ngokwezidingo.

3.3.5 Imiphumela ye-glycerol ne-sorbittol kuma-solubility amanzi amafilimu we-HPMC

(a) glycerol (b) i-sorbibitol

I-Fig.3.5 Umphumela we-Glycerol noma i-sorbitolumon amanzi anlubility yamafilimu we-HPMC

Umdwebo 3.5 ukhombisa umphumela we-glycerol ne-sorbittol kuma-solubility amanzi amafilimu we-HPMC. Kungabonakala kusuka kuMdwebo wokuthi ngokwanda kokuqukethwe kwepulasitiki, isikhathi se-solubel yamanzi isikhathi eside, okungukuthi, i-solubility yamanzi yefilimu ye-HPMC iyancipha kancane kancane, futhi i-glycerol inomthelela omkhulu kumafilimu we-HPMC kune-Sorbibittol. Isizathu esenza i-hydroxypropylllllllylyly methylcellose ine-solubility enhle yamanzi ngenxa yobukhona benani elikhulu lamaqembu ama-hydroxyl ku-molecule yalo. Ukusuka ekuhlaziyweni kwe-infrared spectrum, kungabonakala ukuthi ngokungezwa kwe-glycerol ne-sordity, i-hydroxyl vibration inani lefilimu le-hpmc liyaba buthaka, okubonisa ukuthi inani lamaqembu we-hpmpc liyancipha, ngakho-ke i-hydrophilic file iyancipha.

3.4 izingxenye zalesi sahluko

Ngokuphathelene nokuhlaziywa kokusebenza okungenhla kwamafilimu we-HPMC, kungabonakala ukuthi amapulasitiki i-Glycerol ne-Sorbibitlol athuthukisa izakhiwo zemishini zamafilimu we-HPMC futhi akhuphule ubumbano ekhefu lamafilimu. Lapho ukwengezwa kwe-glycerol kungu-0.15%, izakhiwo zemishini zamafilimu we-HPMC zihle, amandla ashubile acishe abe ngu-60MPA, kanti amandla ekhefu acishe abe ngu-50%; Lapho ukwengezwa kwe-glycerol kungu-0.25%, izakhiwo ze-optical zingcono. Lapho okuqukethwe kwe-SORBITOL kungu-0,15%, amandla ashubile efilimu le-HPMC acishe abe yi-55mpa, futhi ukugcwala ekhefu kukhuphuka ku-45%. Lapho okuqukethwe kwe-SORBITOL kungu-0.45%, izakhiwo zefilimu zingcono. Womabili amapulasitiki anciphise i-solubility yamanzi yamafilimu we-HPMC, kanti i-SORBITOL yayinomthelela omncane kuma-solubility amanzi amafilimu we-HPMC. Ukuqhathaniswa kwemiphumela yalawo mapulasitiki amabili kwizakhiwo zamafilimu we-HPMC kukhombisa ukuthi umphumela weplastiya we-glycerol kumafilimu we-HPMC ungcono kunalokho kwe-sorbibibittol.

ISAHLUKO 4 imiphumela yama-ejenti awela ama-HPMC angenamanzi angenamanzi

4.1 Isingeniso

I-Hydroxypropyl methylcellulose iqukethe amaqembu amaningi ama-hydroxyls namaqembu ama-hydroxypropoxy, ngakho-ke ine-soubelity enhle yamanzi. Leli phepha lisebenzisa i-solubity yalo emihle yamanzi ukulungiselela inoveli eluhlaza okwesibhakabhaka nefilimu yokupakisha yamanzi enobungane. Ngokuya ngesicelo sefilimu elinyibilika amanzi, ukuchithwa okusheshayo kwefilimu elinyibilika amanzi kuyadingeka kuzinhlelo eziningi, kepha kwesinye isikhathi ukuqedwa okubambezelekile nakho kufiswa [21].

Ngakho-ke, kulesi sahluko, i-Glutaraldehyde isetshenziswa njenge-ejenti eguquguqukayo eguquguqukayo yefilimu yokufaka amanzi e-hydroxypropyllylylylylylylylyll methylcellulose, futhi ingaphezulu yalo lixhumene ne-solubiling yamanzi ukunciphisa i-solubility yamanzi yefilimu futhi ukubambezele isikhathi se-soulility yamanzi. Imiphumela ye-Glutaraldehyde ye-Volomu yesengezo e-solubility yamanzi, izakhiwo zemishini kanye nezindawo zokubona ze-hydroxypropylylylylylylylylylylylylylylks zafundwa ikakhulu.

4.2 Ingxenye yokuhlola

4.2.1 izinto zokuhlola nezinsimbi

Ithebula 4.1 Izinto zokuhlola kanye nokucaciswa

4.2.2 Ukulungiselela

1) Isisindo: Linganisa inani elithile le-hydroxypropylllylylyllose (5%) ngokulingana nge-elektroniki;

2) Ukuchithwa: I-hydroxyproppropylylylylyl ingeziwe emanzini alungiselelwe, ivuselelwa emazingeni okushisa asekamelweni kanye nengcindezelo ye-glutaraldehyde (0.44%, 0.44%, i-0.44%), kanye noketshezi olwenziwe ngefilimu nge Amanani ahlukahlukene we-glutaraldehyde angeziwe;

3) Ukwenza Kwefilimu: Faka ifilimu ukwakha uketshezi esitsheni se-petri esilazi bese ulibeka ebhokisini lokomisa umoya ka-40 ~ 50 °

4.2.3 Isimo nokuhlolwa kokusebenza

4.2.3.1 Ukuhlaziywa kwe-Spectroscopy (i-FT-IR)

I-infrared yokumunca kwe-HPMC yanqunywa kusetshenziswa i-Nicolet 5700 Fourier infrared spectrometer ekhiqizwa yinkampani yaseMelika ye-Thermoelectric evale i-spectrum.

4.2.3.2 Ububanzi bokuhlaziywa kwe-X-ray

I-Wide-Angle X-RAY TAGRACTION (XRD) ukuhlaziywa kwesimo se-crystallization sento esezingeni lamangqamuzana. Kuleli phepha, isimo se-crystallization sefilimu elincanyana sinqunywe kusetshenziswa i-arl / xtra X-ray difloctometer ekhiqizwe yi-Thermo Arl yaseSwitzerland. Izimo Zokulinganisa: Umthombo we-X-ray uyi-nickel Filter Cu-Kα Lilly (40 KV, 40 MA). Skena angle kusuka ku-0 ° kuya ku-80 ° (2θ). Skena ijubane 6 ° / min.

4.2.3.3 Ukunqunywa kwamanzi i-solubity: okufanayo ne-2.2.3.4

4.2.3.4 Ukunqunywa Kwezakhiwo Zomshini

Usebenzisa instron (5943) miniature umshini wokuhlola wokuhlola we-Instron Universal of Instrun (Shanghai), ngokusho kwendlela yokuhlola ye-GB1302-92 yezindawo ezingama-25 ° C, ukhethe amasampula ngobukhulu bomfaniswano kanye nendawo ehlanzekile ngaphandle kokungcola.

4.2.3.5 Ukunqunywa Kwezakhiwo Zamehlo

Usebenzisa i-Transmittance Transmittance Haze umhloli, khetha isampula ukuze uhlolwe ngendawo ehlanzekile futhi akukho okushintshiwe, futhi ulinganise ukudluliselwa kokukhanya kanye ne-haze yefilimu ekushiseni kwegumbi (25 ° C no-50% RH).

4.2.4 Ukucutshungulwa kwedatha

Idatha yokuhlola yacutshungulwa yi-Excel futhi ifakwe i-software yemvelaphi.

4.3 Imiphumela Nengxoxo

4.3.1 I-infrared amunction Spectra yamafilimu we-putaraldehyde-crossinked HPMC amafilimu

I-Fig.4.1 FT-IR yamafilimu we-HPMC ngaphansi kokuqukethwe okuhlukile kwe-Glutaraldehyde

I-spectroscopcopy yokumunca infrared iyona ndlela enamandla yokubonisa amaqembu asebenzayo aqukethe esakhiweni samangqamuzana futhi akhombe amaqembu asebenzayo. Ukuze uphinde uqonde ushintsho oluhlelekile lwe-hydroxypropylllyllose ngemuva kokuguqulwa, kwenziwa izivivinyo ze-infrared kumafilimu we-HPMC ngaphambi nangemva kokuguqulwa. Umdwebo 4.1 ukhombisa ububanzi be-infrared of HPMC amafilimu ama-HPMC anamanani ahlukene we-glutaraldehyde, kanye nodoti wamafilimu we-HPMC

Iziqongo zokumunca isifuba se-vibrational of -oh ziseduze kuka-3418cm-1 no-1657c-1. Qhathanisa ububanzi obungenakuqhathaniswa ne-infcrossled infrared of HPMC yamafilimu we-HPMC, kungabonakala ukuthi ngokungezwa kwe-glutaraldehyde, amaqoqo abunjiwe angu-3418cm-1 no-1657cm-1 kanye ne-1657cm-1 no-1657cm - Iqembu le-hydroxypropopoxy lalibuthakathaka kakhulu, libonisa ukuthi inani lamaqembu ama-hydroxypropopoxy lawo I-molecule ye-HPMC yancishiswa, eyabangelwa ukusabela okuxhumanisa phakathi kwamaqembu athile we-hpmc kanye ne-DialdHyde Group ku-Glutaraldehyde [74]. Ngaphezu kwalokho, kwatholakala ukuthi ukungezwa kwe-glutaraldehyde akuzange kuguqule isikhundla senani eliphakeme lokumunca nge-HPMC, okubonisa ukuthi ukungezwa kwe-glutaraldehyde akuzange kubhubhise amaqembu e-HPMC uqobo.

4.3.2 Amaphethini we-XRD wamafilimu we-HPMC angena-crossinked

Ngokwenza ukuguquguquka kwe-X-ray ngezinto ezibonakalayo futhi kuhlaziye iphethini yayo yokungafani, kuyindlela yocwaningo yokuthola imininingwane efana nesakhiwo noma i-molecule yama-athomu noma ama-molecule ngaphakathi kwezinto ezibonakalayo. Umdwebo 4.2 ukhombisa amaphethini we-XRD amafilimu we-HPMC anezengezo ezahlukahlukene ze-Glutaraldehyde. Ngokunyuka kwe-Glutaraldehyde kwezengezo, ubukhulu beziqongo ze-HPMC cishe ngo-9.5 ° no-20.4 °, ngoba ama-Aldehydes ku-Glutaraldehyde Molecule ebuthaka. Ukusabela okuxhumanisayo okwenzeka phakathi kweqembu le-hydroxyl kanye ne-hpdroxyl gerow ku-molecule ye-HPMC, ekhawulela ukuhamba kwe-chain yama-molecular [75], ngaleyo ndlela kunciphisa amandla okuhleleka we-molecule ye-HPMC.

I-Fig.4.2 XRD yamafilimu we-HPMC ngaphansi kokuqukethwe okuhlukile kwe-Glutaraldehyde

4.3.3 Umphumela we-Glutaraldehyde kuma-solubility amanzi amafilimu we-HPMC

Fig.4.3 Umphumela we-Glutaraldehyde kuma-solubility amanzi amafilimu we-HPMC

Kusuka kuMdwebo 4.3 Umphumela wezengezo ezahlukene ze-glutaraldehyde kumafilimu wamanzi amafilimu we-HPMC, kungabonakala ukuthi ngokwanda kwemithamo ye-Glutaraldehyde, isikhathi se-solubel yamanzi isikhathi eside. Ukusabela okuxhumanisayo okuphambanisa kwenzeka nge-Aldehyde Group ku-Glutaraldehyde, okuholela ekunciphiseni okukhulu kwenombolo yamaqembu e-HPMC, ngakho-ke ukunweba i-solubity yamanzi yefilimu ye-HPMC.

4.3.4 Umphumela we-glutaraldehyde kwizakhiwo zemishini zamafilimu we-HPMC

Fig.4.4 Umphumela we-Glutaraldehyde kumandla ashukumisayo kanye nokugqashuka kwamafilimu we-HPMC

Ukuze uphenye umphumela wokuqukethwe kwe-Glutaraldehyde kwizakhiwo zemishini zamafilimu we-HPMC, amandla ashubile kanye nokubumbana lapho kuhlolwe amafilimu aguquliwe. Isibonelo, i-4.4 yigrafu yomphumela wengezo se-Glutaraldehyde kumandla ashubile kanye nokugcwala ekhefu lefilimu. Ngokunyuka kwesengezo se-glutaraldehyde, amandla ashukumisayo kanye nokubumbana ekwephuleni kwamafilimu we-HPMC akhuphuke kuqala bese wehla. umkhuba we. Njengoba ukuxhumeka kwesiphambano se-glutaraldehyde kanye ne-cellulose kungokwanda ukubhebhana, ngemuva kokungeza i-glutaraldehyde kwifilimu ye-HPMC, amaqembu ama-hpdroxyde e-molecule ye-glutaraldehyde esebenzisa ukusabela okuxhumeka kwe-ether, ekhuphula izingxenye zemishini Amafilimu we-HPMC. Ngokungezwa okuqhubekayo kwe-Glutaraldehyde, ukuhlanganisa ukuxhumanisa kusisombululo kukhuphuka, okukhawulela ukuslayida phakathi kwama-molecule, futhi izingxenye zamangqamuzana azithambekele kalula ngaphansi kwesenzo samafilimu angemuva, okubonisa ukuthi izakhiwo zemishini zamafilimu amancane we-HPMC ziyenqaba ama-macroscopically [76]. Kusuka kuMdwebo 4.4, umphumela we-Glutaraldehyde kwizakhiwo zemishini zamafilimu we-HPMC ukhombisa ukuthi lapho ukwengeza i-Glutaraldehyde kungu-0.25%, futhi umphumela we-crosslinking we-HPMC amafilimu angcono.

4.3.5 Umphumela we-glutaraldehyde ezingxenyeni zokubona amafilimu we-HPMC

Ukudlulisela okukhanyayo kanye ne-haze kungamapharamitha amabili asemqoka kakhulu wokusebenza kwamafilimu. Lapho kudlula khona okudlulayo, okungcono kokubonakala kwefilimu; IHaze, eyaziwa nangokuthi turbinity, ibonisa izinga lokungakhethi kwefilimu, futhi likhulu kakhulu i-Haze, okubi kakhulu kwefilimu. Umdwebo 4.5 ungumthelela othonya lokungezwa kwe-glutaraldehyde ezingxenyeni zokubona zamafilimu we-HPMC. Kungabonakala kusuka kuMdwebo wokuthi ngokwanda kokungezwa kwe-glutaraldehyde, ukudluliselwa okukhanyayo kuqala kukhuphuka kancane, bese kukhuphuka ngokushesha bese kuncipha kancane bese kuncipha kancane; I-Haze yaqala ukuncipha futhi yanda. Lapho ukwengeza i-Glutaraldehyde kwakungu-0.25%, i-Transmitance yefilimu ye-HPMC ifinyelele inani eliphakeme lama-93%, futhi i-Haze ifinyelele inani eliphansi le-13%. Ngalesi sikhathi, ukusebenza kwe-optical bekungcono. Isizathu sokwanda kwezakhiwo ezibonakalayo ukusabela okuxhumanisa phakathi kwama-molecule we-glutaraldehyde ne-hydroxypropyll methylcellulose, futhi ilungiselelo le-intermolecular lihlangene kakhulu futhi liyunifomu, elikhulisa izakhiwo ze-hpmc [77-79]. Lapho i-ejenti exhumanisa ngokweqile, amasayithi axhumanisa ngokuwela aphethwe, ukuslayida okuphakathi kwama-molecule wohlelo kunzima, futhi into yejeli kulula ukwenzeka. Ngakho-ke, izakhiwo ezibonakalayo zamafilimu we-HPMC ancishisiwe [80].

Umdwebo4.5 Umphumela we-Glutaraldehyde empahleni ebonakalayo yamafilimu we-HPMC

4.4 Izingxenye zalesi sahluko

Ngokuhlaziya okungenhla, kudonswa iziphetho ezilandelayo:

1) I-infrared Supplerum yefilimu ye-Glutaraldehyde-Cressinked-Cressinked ye-HPMC ikhombisa ukuthi ifilimu le-Glutaraldehyde ne-HPMC libheka ukusabela okuxhumanisayo.

2) Kufanelekile ukwengeza i-Glutaraldehyde ebangeni le-0.25% kuya ku-0.44%. Lapho inani lokungezwa le-glutaraldehyde lingu-0.25%, izakhiwo eziphelele zemishini kanye nezakhiwo ze-optical zefilimu le-HPMC zingcono; Ngemuva kokuxhumanisa ukunqamula, i-solubility yamanzi yefilimu ye-HPMC yande futhi i-solubility yamanzi incishisiwe. Lapho inani lokungezwa le-glutaraldehyde lingu-0.44%, isikhathi se-solubility samanzi sifinyelela cishe ngo-135min.

ISAHLUKO 5 I-ATRIOXIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDIDAD WAMC BAMEble Packeble Packaling Fille

5.1 Isingeniso

Ukuze wandise ukusetshenziswa kwe-hydroxypropylll methylcellose filk ekuphaketheni ukudla, lesi sahluko sisebenzisa i-bamboo leaf antioxidant (AOB) njengendlela yokwengeza yemvelo ye-antioxidant, futhi sisebenzisa isixazululo sendlela yokwenza amaqabunga ama-antioxidants ahlukahlukene. I-Antioxidant HPMC Exboluble Packing Flualiging film, funda izakhiwo ze-antioxidant, i-solubility yamanzi, izakhiwo zemishini kanye nezici zokubona zefilimu, futhi zinikeze isisekelo sohlelo lokusebenza lwayo ezinhlelweni zokupakisha zokudla.

5.2 Ingxenye yokuhlola

5.2.1 izinto zokuhlola nezinsimbi zokuhlola

I-Tab.5.1 Izinto zokuhlola kanye nokucaciswa

Tab.5.2 Izinsizakusebenza zokuhlola kanye nokucaciswa

5.2.2 Ukulungiselela

Lungiselela amafilimu we-hydroxypropyll methylcellose amafilimu angenamanzi angenamanzi anamanani ahlukene ama-bamboo amaqabunga ama-antioxidants ngendlela yokusakaza izixazululo, alungise ngokulinganayo, bese wengeza i-hydroxypropyll methylulose methylcellulose methylcellulose, bese ufaka u-0.05%, 0.05%, 0.05%, 0.05%, 0.07%, 0.05%, I-0.09%) yama-bamboo amaqabunga ama-antioxidants kwikhambi elakha amafilimu, bese uqhubeka nokuvusa

Ukuxutshwa ngokuphelele, ake ume emazingeni okushisa asekamelweni imizuzu emi-3-5 (ukungcolisa) ukulungiselela izixazululo zefilimu ze-HPMC eziqukethe izingxenyana ezihlukile ze-bamboo amaqabunga ama-antioxidants. Yomisa kuhhavini osomile, bese uyibeka kuhhavini osomile ukuze usetshenziswe kamuva ngemuva kokukhipha ifilimu. Ifilimu elungiselelwe ama-hydroxyproppropyl whellulose fille filimu efakwe ngamanzi angezwe nge-bamboo leaf antioxidant kubhekiselwa kuyo njengefilimu ye-AOB / HPMC emfushane.

5.2.3 Isimo nokuhlolwa kokusebenza

5.2.3.1 Ukuhlaziywa kwe-spectroscopy (i-ft-ifrared

I-infrared incrareption Spectra yamafilimu we-HPMC alinganiswa kwimodi ye-ATR esebenzisa i-NICOLET 5700 Fourier Transform Infrared Spectrometer ekhiqizwe yi-Thermoelectric Corporation.

5.2.3.2 ubukhulu be-X-RAY X-RAY

5.2.3.3 Ukunqunywa kwezakhiwo ze-antioxidant

Ukuze ulinganise izakhiwo ze-antioxidant zamafilimu we-HPMC alungiselelwe kanye namafilimu we-AOB / HPMC, indlela ye-DPPH yamahhala ye-radical scavenging yasetshenziswa kulolu vivinyo ukukala izinga lokuvimbela amafilimu kumafilimu.

Ukulungiselela Isixazululo se-DPPH: Ngaphansi kwezimo ezinomthunzi, chaza 2 mg we-DPPP ku-40 ml we-ethanol solvent, futhi ubuntu imizuzu emi-5 ukwenza umfaniswano wesisombululo. Gcina esiqandisini (4 ° C) ukuze usetshenziswe kamuva.

Ebhekisa kwindlela yokuhlola ye-zhong yuansheng [81], ngokuguqulwa okuncane, ukulinganisa kwenani le-A0: Thatha i-2 ml yamanzi e-DPPh ukuze unikine futhi uhlanganise inani (519nm) nge-UV spectrophotometer. yi-a0. Ukukalwa kwenani: Faka u-2 ml wesisombululo se-DPPH ku-tube yokuhlola, bese ufaka i-1 ml ye-HPMc fill solution ukuxuba kahle, ulinganise inani nge-UV spectrophotometer, uthathe amanzi njengokulawula okufanayo kweqembu ngalinye. Indlela yokubala yokubala ye-DPPH yamahhala ye-DPPH yamahhala isho ifomula elandelayo,

Kwifomula: A ukumunca isampula; I-A0 ukulawula okungenalutho

5.2.3.4 Ukunqunywa kwezimpahla zemishini: Kuyafana ne-2.2.3.2

5.2.3.5 Ukunqunywa Kwezakhiwo Zamehlo

Izakhiwo ze-Optical kuyizinkomba ezibalulekile zokubonakala kwamafilimu okupakisha, ikakhulukazi kufaka phakathi ukudluliselwa kanye ne-haze yefilimu. Ukudluliselwa kanye neHaze lamafilimu alinganiswa kusetshenziswa umhloli we-haze transmitance. Ukudluliselwa kokukhanya kanye neHaze lamafilimu alinganiswe emazingeni okushisa asekamelweni (25 ° C no-50% RH) kumasampula wokuhlola anezindawo ezihlanzekile futhi akukho okuvuthisiwe.

5.2.3.6 Ukunqunywa kwamanzi i-solubity

Sika ifilimu engu-30mm × 30mm ngobukhulu obungama-45μM, engeza ama-100ml wamanzi ku-weaker engu-200ml, beka ifilimu maphakathi nendawo yamanzi, bese ukala isikhathi sefilimu ukuba inyamalale ngokuphelele. Uma ifilimu inamathela odongeni lwe-beaker, idinga ukulinganiswa futhi, futhi umphumela uthathwa njengezilinganiso ezi-3, iyunithi min.

5.2.4 Ukucutshungulwa kwedatha

Idatha yokuhlola yacutshungulwa yi-Excel futhi ifakwe i-software yemvelaphi.

5.3 Imiphumela nokuhlaziywa

5.3.1 FT-IR Ukuhlaziywa

Fig5.1 I-FTIR ye-HPMC ne-AOB / HPMC yamafilimu

Kuma-molecule ezi-organic, ama-athomu akha amabhondi zamakhemikhali noma amaqembu asebenzayo asesimweni sokudlidliza njalo. Lapho ama-molecule e-organic exhumeka ngokukhanya okungekho emthethweni, amabhondi zamakhemikhali noma amaqembu asebenzayo kuma-molecule angadonsa ukunyakaza, ukuze imininingwane ngamakhemikhali wamakhemikhali noma amaqembu asebenzayo ku-molecule angatholakala. Umdwebo 5.1 ukhombisa i-ftir spectra yefilimu ye-HPMC ne-AOB / HPMC film. Kusuka kuMdwebo 5, kungabonakala ukuthi ukudlidliza kwamathambo okucacile kwe-hydroxypropyllllylylylylylylylylylylylylylylylyll methylcellulose kugxile kakhulu ku-2600 ~ 3700 cm-1 no-750 ~ 1700 cm cm cm-1. Imvamisa enamandla yokudlidliza esifundeni esingu-950-1250 cm-1 ikakhulukazi isifunda esibonisa ukudliwa kwamathambo. I-Band Absorption yefilimu ye-HPMC eduze kwe-3418 cm-1 ibangelwa ukudlidliza okwenziwe nge-Oh Bond, kanye nenani eliphakeme leqembu le-hydroxypropoxy eqenjini le-hydroxypropoxy ku-1657 cm-1 kubangelwa ukudlidliza kokululwa kohlaka [82]. Iziqongo zokumuncwa ngo-1454cm-1, 1373CM-1, 1315cm-1, 1315cm-1 no-945cm-1 zazingezelwa ukunyakaza kwe-asymmetric, ukudlidliza kwe-symmetrical, endizeni nasezindizeni ezinolaka nge--503]. I-HPMC yaguqulwa nge-AOB. Ngokungezwa kwe-AOB, isikhundla senani eliphakeme lesici se-AOB / HPMC alizange lisuke, libonisa ukuthi ukungezwa kwe-AOB akuzange kubhubhise amaqembu e-HPMC uqobo. Ukudlidliza okwelule kwe-OH Bond ku-Bhange ye-Absorption yefilimu ye-AOB / HPMC eduze kwe-3418 cm 12], kungabonakala ukuthi ukungezwa kwe-AOB kunomthelela kuma-permolecular ama-hydrogen bond.

5.3.2 Ukuhlaziywa kwe-XD

Fig.5.2 XRD we-HPMC ne-AOB /

I-Fig.5.2 XRD ye-HPMC ne-AOB / HPMC yamafilimu

Isimo se-Crystalline samafilimu sahlaziywa nge-Wide-ray difraction. Umdwebo 5.2 ukhombisa amaphethini we-XRD amafilimu we-HPMC namafilimu we-AAOB / HPMC. Kungabonakala kusukela kuhlamvu lokuthi ifilimu ye-HPMC ineziqongo ezi-2 ezihlukile (9.5 °, 20.4 °). Ngokungezwa kwe-AOB, iziqongo ezihambisanayo cishe ngo-9.5 ° no-20.4 ° zibuthakathaka kakhulu, okukhombisa ukuthi ama-molecule efilimu ye-AOB / HPMC ahlelwe ngendlela ehlelekile. Amandla anciphile, okukhombisa ukuthi ukungezwa kwe-AOB kuphazamise ukuhlelwa kwe-hydroxypropylyllyllose methylcellose cweach, wachitha nokwakheka kwe-crystal yasekuqaleni kwe-molecule, futhi kunciphise ukuhlelwa okujwayelekile kwe-hydroxypropylylylylylylylylyl.

5.3.3 Izakhiwo ze-antioxidant

Ukuze uhlole umphumela wokungezwa kwe-AOB okuhlukile kumafilimu we-oob / hpmc, amafilimu anezengezo ezahlukahlukene ze-AOB (0, 0.01%, 0.05%, 0.09%) aphenywa, ngokulandelana. Umphumela wesilinganiso sokuhlaselwa kwesisekelo, imiphumela ikhonjiswa kuMfanekiso 5.3.

Umdwebo5.3 Umphumela wamafilimu we-HPMC ngaphansi kokuqukethwe kwe-AOB ku-DPPH

Kungabonakala kusuka kuMfanekiso 5.3 ukuthi ukungezwa kwe-antioxidant ye-AOB antioxidant kakhulu ye-DPPP radicals ngamafilimu we-HPPC, okungukuthi, ukwanda kwe-ATPPPAsks kukhuphuke ekuqaleni kwesikhathi lapho kwehla kancane kancane. Lapho inani lokungezwa le-AOB lingu-0.03%, ifilimu ye-AOB / HPMC inomphumela omuhle kakhulu kumazinga okufaka ama-DPPH ama-radicals we-DPPH afinyelela kuma-89.34%, okungukuthi, ifilimu le-AOB / HPMC linokusebenza okuhle kakhulu koxidation ngalesi sikhathi; Lapho okuqukethwe kwe-AOB bekungu-0.05% no-0.07%, isilinganiso samafilimu we-DPPH samahhala sefilimu ye-AOB / HPMC sasiphakeme kunalokho kweqembu le-0.01%, kepha liphansi kakhulu kunaleqembu le-0.03%; Lokhu kungahle kube ngenxa ye-antioxidant yemvelo eyengeziwe ukwengezwa kwe-AOB okuholwa yi-agglomeration yama-molecule e-aob kanye nokusatshalaliswa okungalingani kwifilimu, ngaleyo ndlela kuthinta umphumela we-antioxidant Films of AoB / HPMC. Kungabonakala ukuthi ifilimu ye-AOB / HPMC elungiselelwe ku-Adminer inokusebenza okuhle kwe-anti-oxidation. Lapho inani lokungezwa lingu-0.03%, ukusebenza kwe-anti-oxidation yefilimu ye-AOB / HPMC kunamandla kakhulu.

5.3.4 I-solubity yamanzi

Kusuka kuMdwebo 5.4, umphumela we-bamboo leaf antioxidants kuma-solubility amanzi we-hydroxypropyllll films, kungabonakala ukuthi izengezo ezahlukahlukene ze-AOB zinomphumela omkhulu kumafilimu wamanzi. Ngemuva kokungeza i-AOB, ngokwanda kwenani le-AOB, isikhathi esinyibilikayo samanzi sasifushane, esibonisa ukuthi ukugcwala kwamanzi kwefilimu ye-AOB / HPMC bekungcono. Lokho kusho ukuthi, ukungezwa kwe-AOB kuthuthukisa i-AoB / HPMC yamanzi anlubility yefilimu. Ukusuka ekuhlaziyweni kwe-XD yangaphambilini, kungabonakala ukuthi ngemuva kokungeza i-AOB, ifilimu yefilimu ye-AOB / HPMC iyancishiswa, futhi amandla phakathi kwama-molecule wamanzi abuthakathaka, ngakho-ke ifilimu ye-AOB / HPMC ithuthukiswa ngezinga elithile. Ukuhlukunyezwa kwamanzi kwefilimu.

I-Fig.5.4 Umphumela we-AOB in soluble yamanzi amafilimu we-HPMC

5.3.5 Izakhiwo zemishini

I-Fig.5.5 Umphumela we-AOB kumandla ashukumisayo kanye nokugqashuka kwamafilimu we-HPMC

Ukusetshenziswa kwezinto ezicijile amafilimu kubanzi kakhulu futhi kuningi kakhulu, futhi izakhiwo zalo zemishini zinethonya elikhulu ekuziphatheni kwensiza kwama-membrane-based systems, esephenduke i-hotspot enkulu yocwaningo. Umdwebo we-5.5 ukhombisa amandla ashukumisayo kanye nokugcwala ngama-curve wekhefu amafilimu we-AOB / HPMC. Kungabonakala esifanekisweni esingezelelweyo se-AOB sinemiphumela ebalulekile kwizakhiwo zemishini zamafilimu. Ngemuva kokungeza i-AOB, ngokwanda kwesengezo se-AOB, AOB / HPMC. Amandla ashubile wefilimu akhombisa ukuthambekela phansi, kuyilapho ukugcwala kwekhefu kukhombisa ukuthambekela kokuqala kwanda kwalapho kuncipha. Lapho okuqukethwe kwe-AOB bekungu-0.01%, ukugcwala ekwephuleni kwefilimu kufinyelele inani eliphakeme elingaba ngu-45%. Umphumela we-AOB kwizakhiwo zemishini zamafilimu we-HPMC asobala. Ukusuka ekuhlaziyweni kwe-XRD, kungabonakala ukuthi ukungezwa kwe-antioxidant aob kunciphisa i-crystaltaltity yefilimu ye-AOB / HPMC, ngaleyo ndlela kunciphisa amandla ashubile efilimu ye-AOB / HPMC. I-elongation ekwephuleni ikhefu lenyuka liyakhula bese liyancipha, ngoba i-AOB ine-solubility yamanzi nokuhambisana kwamanzi nokuhambisana, futhi kuyinto encane yamangqamuzana. Ngesikhathi senqubo yokuhambisana ne-HPMC, amandla okuxhumana phakathi kwama-molecule abuthakathaka futhi ifilimu lithanjiswa. Isakhiwo esiqinile senza ifilimu ye-AOB / HPMC ithambile futhi ukugcwala kwekhefu lefilimu kuyanda; Njengoba i-AOB iyaqhubeka nokwanda, ukugcwala kwefilimu ye-AOB / HPMC kuyancipha, ngoba ama-molecule e-AOB / HPMC enza i-macromolecule ye-macromolecule, futhi akukho phuzu lokuvama phakathi kwe-AOB / HPMC Ifilimu liyancipha.

5.3.6 Izakhiwo ze-Optical

Fig.5.6 Umphumela we-AOB EPHELELE IPASTILIKI LAMAKHASIMU WE-HPMC

Umdwebo we-5.6 uyigrafu ekhombisa ushintsho ekudluliseleni naseHaze lamafilimu we-AOB / HPMC. Kungabonakala kulokho okuthi ngokwanda kwenani le-AOB elingeziwe, ukudluliselwa kwefilimu le-AOB / HPMC kuyancipha futhi kukhuphuke ukwanda kweHaze. Lapho okuqukethwe kwe-AOB kungedlula i-0.05%, amazinga okushintsha wokudluliselwa kokukhanya kanye ne-haze yamafilimu we-AOB / HPMC ayehamba kancane; Lapho okuqukethwe kwe-AOB kudlula u-0.05%, amazinga okushintsha wokudluliselwa kwe-Light Transmittance kanye ne-haze asheshisiwe. Ngakho-ke, inani le-AOB elingeziwe akufanele lidlule ku-0.05%.

5.4 izingxenye zalesi sahluko

Ukuthatha i-bamboo leaf antioxidant (AOB) njenge-antioxidant yemvelo ne-hpmpypropyll methylcellulose (HPMC) njenge-matrix ekwakheka ifilimu, uhlobo olusha lwefilimu yemvelo ye-antioxidant yalungiswa ngesisombululo sokuhlanganisa nokuphonsa indlela eyakha amafilimu. Ifilimu yokupakisha yamanzi ye-AOB / HPMC engenayo elungiselelwe kulokhu kuhlolwa inezakhiwo ezisebenzayo ze-anti-oxidation. Ifilimu ye-AOB / HPMC ene-0.03% AOB inesilinganiso esingama-89% ama-radicals wamahhala we-DPPH, kanye nokusebenza kahle kwe-scaveling kungcono kakhulu, okungcono kunalokho ngaphandle kwalokhu ngaphandle kwalokhu ngaphandle kwe-AOB. Ifilimu le-HPMC ku-61% ngcono. I-soubelility yamanzi nayo ithuthukiswa kakhulu, futhi izakhiwo zemishini nezindawo zokubona zincishisiwe. Ukumelana nokuphikiswa kwe-oxidation okuthuthukile kwezinto zefilimu ze-AOB / HPMC zikhulise uhlelo lwayo ekuphaketheni ukudla.

Isahluko Se-ViE

1) Ngokunyuka kwesixazululo sokwakha izixazululo ze-HPMC, indawo yefilimu yanda okokuqala yabe sekwehliswa. Lapho i-HPMC ekwakheni iFilling Solution Isixazululo sasingama-5%, izakhiwo zemishini zefilimu le-HPMC zazingcono, futhi amandla ashubile ayengu-116MPA. Ukugcwala ekhefu cishe ngo-31%; izakhiwo ze-optical kanye nokuncipha kwamanzi.

2) Ngokukhuphuka kwamazinga okushisa akha amafilimu, izindawo zemishini zamafilimu anda kuqala bese zehla, izakhiwo zokukhanya zithuthukile, futhi amanzi e-solubity ancipha. Lapho amazinga okushisa akha amafilimu angu-50 ° C, ukusebenza okuphelele kungcono, amandla ashubile acishe abe ngu-116mpa, ukudluliselwa kokukhanya kucishe kube ngu-95min, ngakho-ke isikhathi sokushisa samafilimu sisebenza ngo-50 ° C.

3) Usebenzisa amapulasitiki ukwenza ngcono ubulukhuni bamafilimu we-HPMC, ngokufakwa kwe-Glycerol, ukunwebeka ekwephuleni kwamafilimu we-HPMC kukhuphuke kakhulu, kanti amandla ashubile ancipha. Lapho inani le-Glycerol elingeziwe laliphakathi kuka-0.15% no-0.25%, ukugcwala ekhefu lefilimu le-HPMC kwakungama-50%, futhi amandla ashubile ayecishe abe ngu-60MPA.

4) Ngokungezwa kwe-sorbibibittol, ukugcwala ekwephuleni kwefilimu kukhuphuka kuqala bese kuncipha. Lapho ukwengeza kwe-SORBOL kucishe kube ngu-0.15%, ukugcwala ekhefu kufinyelela kuma-45% kanti namandla ashubile acishe abe ngu-55MPA acishe abe yi-55mpa.

5) Ukungezwa kwamapulasitiki amabili, i-glycerol ne-sorbitol, zombili zinciphise izakhiwo ze-optical kanye ne-solubity yamanzi yamafilimu we-HPMC, futhi ukwehla kwakungekuhle. Ukuqhathanisa umphumela wepulasitiki walawo mapulasitiki amabili kumafilimu we-HPMC, kungabonakala ukuthi umphumela weplastiya we-glycerol ungcono kunaleso sorbibibibibit.

6) ngokusebenzisa i-infrared amunction Spectroscopy (FTIR) kanye nokuhlaziywa kwe-X-RAY X-RAY X-RAY, ukuxhumeka kwe-Glutaraldehyde ne-HPMC kanye ne-crystallity ngemuva kokuxhumana ngokuxhuma. Ngokungezwa kwe-ejenti exhumanisa i-glutaraldehyde, amandla ashubile kanye nokubumbana ekwephuleni kwamafilimu alungiselelwe we-HPMC anda kuqala abe esencipha. Lapho ukwengezwa kwe-glutaraldehyde kungu-0,5%, izakhiwo eziphelele zemishini zamafilimu we-HPMC zingcono; Ngemuva kokuxhumanisa ukuwela, isikhathi sokuqina kwamanzi isikhathi eside, futhi ukuhlukunyezwa kwamanzi kuyancipha. Lapho ukungezwa kwe-glutaraldehyde kungu-0.44%, isikhathi sokuzinikela samanzi sifinyelela cishe nge-135min.

7) Ukungeza inani elifanele le-antioxidant yemvelo yemvelo kwikhambi elakha amafilimu lefilimu le-HPMC, ifilimu elungiselelwe ye-AOB / HPMC EXSHELLE-AMULEKILE EXOLLULEKILE IMITHETHO inezindawo ezisebenzayo ze-anti-oxidation. Ifilimu le-AOB / HPMC eline-0.03% aob angezwe u-0.03% AOB to Scavenge DPPH Free Radicals Izinga lokususa licishe libe ngu-89%, kanti ukusebenza kahle kwe-61% kuphakeme kakhulu kunalokho kwefilimu le-HPMC ngaphandle kwe-AOB. I-solubility yamanzi nayo yathuthukiswa kakhulu, futhi izakhiwo zemishini kanye nezakhiwo ze-optical zincishisiwe. Lapho inani lokungezwa le-0.03% aob, umphumela wefilimu ulungile, futhi ukuthuthukiswa kokusebenza kwe-anti-oxidation yefilimu ye-AOB / HPMC kunwebisa ukusetshenziswa kwalokhu okufakwayo kwamafilimu.