Ukulungiselela kanye nokusetshenziswa kwe-hydroxypropylylylylym methyl cellulose

I-Hydroxypropylylylylylyllose (i-hypromellose) ingumhlophe onsundu noma i-pellet ye-cellulose noma i-pellet enezici zokuncibilika emanzini abandayo kanye nokungabonakali emanzini ashisayo afana ne-methyl cellulose. I-Hydroxypropyl Group ne-Methyl Group yindandatho ye-glucose ye-ether kanye ne-cellulose anhydrous glucose ihlangene, iyi-ethervuse engenasici exubile. Kuyinto esetshenziswayo, engasebenzi, i-viscoelastic polymer evame ukusetshenziswa ku-ophthalmology njenge-lubrient noma njenge-excipient noma i-excipied ezidakamizweni zomlomo

Ukulungiswa kwe
I-Kraft Phepha Pulp nge-α-cellulose okuqukethwe okungu-97%, i-intercutic viscosity ye-720ml / g nobude obumaphakathi wefiber e-2.6mm bafakwe ku-49% isixazululo ku-50 ℃ imizuzwana engama-40. I-pulp ephumayo yathuthukiswa ukuze isuse imali engaphezulu kuka-49% i-naoh aquali. Isilinganiso sesisindo se (49% naoh emanzini) ku- (Ingxenye eqinile epulp) ku-Suctiongnation Step yayingu-200. Isilinganiso sesisindo (ingxenye ye-Naeh (ingxenye eqinile epulp) yayingu-1.49. Ngakho-ke, i-Alkali Cellulose (20KG) itholwe ngaleyo ndlela ibekwa emhlanganweni wengcindezi we-Jackented ngokuphazamiseka kwangaphakathi bese icishwa futhi ihlanzwe ngegesi ye-nitrogen ukuze isuse ngokwanele i-oksijini e-reactor. Ngemuva kwalokho, izinga lokushisa elikuphendukayo lalilawulwa ngo-60 ℃, ngenkathi kwenziwa okuvuselelwa kwangaphakathi. Kwangezwa i-2.4kg ye-dimethyl ether futhi izinga lokushisa elikuphendukayo lalilawulwa ukuthi lilawulwa ku-60 ° C. ngemuva kokufakwa kwe-molar caltule, 1.97, and the temperature in the reactor was controlled from 60 ° C to 80 ° C. After the addition of chloromethane and propylene oxide, the temperature in the reactor was controlled from 80℃ to 90℃. Ngaphezu kwalokho, ukusabela kwagcinwa ku-90 ° C imizuzu engama-20. Ngemuva kwalokho, igesi liyakhishwa kusuka kumhlaziyi, futhi i-crude hydroxyproppropylllylylylylylylyl methyl cellulose isuswa ku-reactioc. Izinga lokushisa le-crude hydroxypropyll methylcellose lalingu-62 ℃ lapho lisuswa. Kala usayizi we-50% we-50% wesayizi wezinhlayiyana esekwe kusayizi osuselwa kusayizi osuselwa ku-ratio of Crude hydroxypropylyllylylylylylyllose methylcellulose edlula ngosayizi ohlukile wokuvula. Ngenxa yalokhu, ubukhulu obuphakathi kwezinhlayiyana kwezinhlayiyana ezinzima ngu-6.2mmm. I-methylcellopyproselroserprosellose ye-crude yangeniswa ku-biaxial Kneader (LRC Konverer S1, L / D = 10.2, ivolumu yangaphakathi 0,12 l, i-Talloration Speed ​​150rpm) ngejubane le-10kg / hr ukuthola i-crude hydroxypropylyl methysopylyl. Njengoba kulinganiswa ngokufanayo usebenzisa izikrini ezinhlanu ezinosayizi ohlukile wokuvula, ubukhulu bezinhlayiyana eziyingxenye kwakungu-1.4mm. I-slurry yatholwa ngokungeza amanzi ashisayo ku-80 ° C kuya ku-crude hydroxypropyll methylcellulose ethangini nge-methylcellulose eluhlaza okwesikhashana i-hydroxypropylwose methylcellulose) ishintshiwe. I-slurry yavuselelwa emazingeni okushisa ahlala njalo angama-80 ° C imizuzu engama-60. Ngemuva kwalokho, i-slurry inikezwa isihlungi sengcindezi ejikelezayo (i-BHS Sonthofen Product) ngesivinini sokujikeleza esingu-0,5 rpm futhi sifudumele. Izinga lokushisa le-slurry lalingu-93 ℃. I-slurry ihlinzekwa yimpompo enomfutho wokukhipha u-0.2MPA. Usayizi wokuvula wesihlungi sengcindezi ejikelezayo yi-80μm, kanti indawo ye-filtration ingu-0,12m2. I-slurry enikezwe isihlungi se-Rotary Pressure ihlungwa ngesihlungi bese iguqulwa ibe yikhekhe lokuhlunga. Ikhekhe eliphumayo landlisiwe ngomusi ka-0.3MPA namanzi ashisayo ku-95 ° C kuya kwesilinganiso sesisindo esingu-10.0 kwingxenye eqinile ye-hydroxyproppropylles yashelwa yi-methylcellulose. Amanzi ashisayo anikezwa yipompo enomfutho wokukhipha we-0.2MPA. Ngemuva kokuthi amanzi ashisayo ahlinzekwa, u-0.3mpa weSteam uyanikezwa. Umkhiqizo ogeziwe ebusweni besihlungi bese ususwa ku-scraper futhi ukhishwe ngaphandle kwe-washer. Izinyathelo eziqhubekayo ezivela ekunikezelweni kwe-slurry ekukhipheni umkhiqizo ogeziwe. Okuqukethwe kwamanzi komkhiqizo ogeziwe kwakungu-52.8% njengoba kulinganiswa ngokushisa ukomisa i-hygrometer. Imikhiqizo egeziwe ekhishwe kusuka kuhlu lokucindezela lwe-Rotary yomile kusetshenziswa ukomisa komoya ku-80 ° C futhi ichotshozwe emthonjeni onqobayo uMutho lokunqobayo ukuze athole i-Hydroxypropyll methylcellulose.

isicelo
Lo mkhiqizo usetshenziswa njenge-ejenti ekhuthele, ehlakazekile, i-Binder, eMulsifier ne-Stabilizer embonini yezindwangu. Isetshenziswa kabanzi ku-resin zokwenziwa, i-petrochemical, ceramic, iphepha, isikhumba, umuthi, ukudla, izimonyo kanye nezinye izimboni.