Ingabe i-HPMC yokwenziwa noma yemvelo?

I-Hydroxypropyl Methylcellulose (HPMC) iyindawo ehlukahlukene esetshenziswa ezimbonini ezahlukahlukene, ezisukela emikhakheni ekwakheni. Izakhiwo zayo kanye nezinhlelo zokusebenza zithole ukunakwa okukhulu, okuholela emibuzweni ngemvelaphi yayo nokwakheka okuqondile - noma ngabe kungokwenziwa noma okwemvelo.

1. Ukuqonda i-hydroxypropylllyllose methylcellulose (HPMC)

I-HPMC ingukusulwa okuguqulwe ngamakhemikhali kwe-cellulose, okwenzeka ngokwemvelo polysaccharide etholakala ezindongeni zeseli zezitshalo. Kuthathwe ngokuthezeka kwe-cellulose nge-propelene oxide kanye ne-methyl chloride, okuholela engxenyeni eyingqayizivele ehlukile ehlukile kubukhosi bayo.

2. Inqubo ye-synthesis

Ukuhlanganiswa kwe-HPMC kufaka izinyathelo eziningana. Ekuqaleni, iselula ikhishwa emithonjeni yezitshalo enjenge-solip pulp noma amabutho ekotini. Le mbumbulu ithola ukwelashwa nge-Alkali ukwenza i-Alkali Cellulose. Kamuva, kwenziwa i-oxylene oxide ne-methyl chloride ku-Alkali Cellulose ngaphansi kwezimo ezilawulwayo, okuholela ekufakweni kwamaqembu ama-hydroxypropyl namaqembu we-methyl. Izinga lokufaka esikhundleni (DS) linquma izakhiwo ze-HPMC ephumela, kufaka phakathi i-viscosity yayo, i-solubity, kanye nokuziphatha okushisayo.

3. Isakhiwo samangqamuzana

Ukwakheka kwamangqamuzana kwe-HPMC kuhlanganisa uchungechunge lwama-glucose amayunithi, aze ku-cellulose, nge-hydroxypropyl kanye namaqembu we-methyls anamathele kwezinye izikhundla ze-hydroxyl (-oh). Lezi zinto ezifakiwe zidlulisela i-hydrophobicity kanye nesithiyo esiyisithiyo, ukuguqula izici zomzimba nezamakhemikhali ze-polymer. Izinga nokusatshalaliswa kwalezi zinto ezifakiwe kuthonya izakhiwo ze-polymer, okwenza kube ngezifiso ngezicelo ezahlukahlukene.

4. Izicelo ze-HPMC

I-HPMC ithola ukusetshenziswa okubanzi kuyo yonke imboni ehlukahlukene ngenxa yezakhiwo zayo ezihlukile:

Izemithi: Emakhethini emithi, i-HPMC isebenza njengesithako esibucayi ezinhlelweni zokulethwa kwezidakamizwa, kufaka phakathi amaphilisi, amaphilisi kanye nokwakhiwa kwezindawo eziphezulu. Isebenza njenge-binder, i-viscosity modindows, kanye nefilimu yangaphambili, iqinisekisa ukukhishwa okulawulwa kwezithako ezenziwa ngemithi (API) kanye nokwenza ngcono ukulandelwa kweziguli.

Ukwakhiwa: I-HPMC isetshenziswa ezintweni zokwakha ezinjenge-cemerasters zodaka, ama-plasters kanye nama-tile anamathela. Isebenza njengomphathi omkhulu, i-ejenti yokugcina amanzi, kanye ne-rheology modifier, ukuthuthukisa ukukhiqizwa, ukunamathela, nokuqina kwemikhiqizo yokugcina.

Imboni yokudla: I-HPMC ivunyelwe ukusetshenziswa njengesengezo sokudla, ngokuyinhloko njengomuntu omkhulu, i-stabilizer, kanye ne-emulsifier ekudleni okuhlukahlukene okucutshunguliwe, kufaka phakathi amasoso, ama-dessert kanye nemikhiqizo yobisi. Imvelo yayo ye-inert kanye nokuntuleka kobuthi kukwenza kube okuphephile ukuze kusetshenziswe.

Imikhiqizo yokunakekelwa komuntu siqu: I-HPMC ifakwa kwizimonyo, ama-skincare, kanye nokwakheka kwezinwele zokunakekelwa kwezinwele kwezokwakha amafilimu, ukuqina, kanye nokuzinza izakhiwo. Ithuthukisa ukuthungwa komkhiqizo, ukubukeka, kanye nokusebenza ngaphandle kokubangela ukucasuka kwesikhumba.

I-5. Zokwenziwa vs. ukuhlukaniswa kwemvelo

Ukuhlukaniswa kwe-HPMC njengokungenziwa kokwenziwa noma kwemvelo kuyindaba yenkulumompikiswano. Ngakolunye uhlangothi, i-HPMC isuselwa ku-cellulose, i-polymer eyenzeka ngokwemvelo eminingi egcwele ezitshalweni. Kodwa-ke, ukuguqulwa kwamakhemikhali abathintekayo ekuhlolweni kwalo nge-propelene oxide kanye ne-methyl chloride - kuphumela endaweni enezinto eziguquliwe ezingenakutholakala kumlingani wayo wemvelo. Ngaphezu kwalokho, inqubo yokukhiqiza ye-HPMC ifaka ukusabela kwamakhemikhali ezimboni ezimboni, okungaphakamisa ukukhathazeka mayelana nokuhlukaniswa kwayo njengomkhiqizo wemvelo.

Abasekeli bokuhlukaniswa kokwenziwa bathi ukuguqulwa kwamakhemikhali okwenziwe ku-cellulose kuyiguqula kube yindawo ehlukile ngezimpawu zokwenziwa. Bagcizelela ukubandakanyeka kwama-reagents zokwenziwa kanye nezinqubo ekwenziweni kwe-HPMC, kugqamisa ukuhamba kwayo ekutholeni ngokwemvelo kuselula.

Ngakolunye uhlangothi, abameli bokuhlukaniswa kwemvelo baphikisana nokuthi i-HPMC igcina ukwakheka okuyisisekelo kwe-cellulose, yize ngokuguqulwa. Baphikisana nokuthi kusukela ku-cellulose kuthathwe kwimithombo yezitshalo evuselelekayo, i-HPMC ingabhekwa njengento etholwa yimvelo yemvelo. Ngaphezu kwalokho, bagomela ukuthi ukuguqulwa kwamakhemikhali abathintekayo ezinqubweni zayo zokuhlanganiswa ezilingisa ngokwemvelo, yize zisesimweni esilawulwayo sezimboni.

6. Ukucatshangelwa kokulawula

Ngokombono wokulawula, ukuhlukaniswa kwe-HPMC kuyahlukahluka ngokuya ngomongo kanye namandla. Kwezinye izindawo, njenge-European Union kanye ne-United States, i-HPMC ivame ukubukwa njenge-polymer yemvelo etholakala ku-cellulose. Ngenxa yalokho, kungaphansi kwemithethonqubo elawula izithasiselo zokudla, ama-excipietics amakhamishini, kanye nezimonyo.

Kodwa-ke, imizimba ethile yokulawula ingabeka izidingo ezithile noma imikhawulo ekusetshenzisweni kwe-HPMC esuselwa ohlelweni lwayo oluhlosiwe kanye namazinga okuhlanzana. Isibonelo, i-HPMC ye-Phasen-grade kumele ihlangabezane nenqubo eqinile maqondana nobumsulwa, ukubonakala, kanye nokungabikho kokungcola ukuze kuqinisekiswe ukuphepha kwayo kanye nokusebenza kahle kwezidakamizwa.

7. Isiphetho

I-Hydroxypropylm methylcellulose (HPMC) ithatha indima ebaluleke kakhulu kuyo yonke imboni ehlukahlukene, ngenxa yezindawo zayo eziguquguqukayo kanye nezicelo. Ngenkathi ukuhlanganiswa kwayo kubandakanya ukuguqulwa kwamakhemikhali ngokwenzeka ngokwemvelo, impikiswano ezungeze ukuhlukaniswa kwayo njengezinto zokwenziwa noma zemvelo. Abasekeli bazo zombili izindlela banikela ngokuxabana okuphoqayo, kukhombisa ukuxhumeka okuyinkimbinkimbi phakathi kokuhlanganiswa kwamakhemikhali, ukuguqulwa okuhlelekile, kanye nemvelaphi yemvelo.

Akunandaba nokuhlukaniswa kwayo, i-HPMC iyaqhubeka nokubaluleka kokusebenza kwayo, ukuphepha, kanye nokusimama. Njengoba ukucwaninga kwentuthuko kanye nezinhlaka zokulawula zivela, ukuqonda okukhohlisayo kwezakhiwo ze-HPMC kanye nemvelaphi ye-HPMC kuzobaluleka ekuthatheni izinqumo ezinolwazi embonini, ezemfundo kanye nezinhlaka zokulawula.