Ingabe isitshalo se-HPMC sisuselwa?

I-Hydroxypropyl Methylcellulose (HPMC) iyindawo esetshenziswa kabanzi emikhakheni ehlukahlukene, esukela emikhakheni emikhakheni yokudla ezintweni zokwakha. Ukusebenza kwayo kwayo nokusebenza kwenza kube ukukhetha okuthandwayo kwezicelo eziningi eziningi. Umbuzo owodwa ovame ukuba kuphakame ukuthi ngabe i-HPMC isuselwe yini noma isuselwa emithonjeni yezilwane.

I-1.ORIGINS ye-HPMC:
I-HPMC iyi-polymer ye-semi-zokwenziwa ethathwe ku-cellulose, okuyinto eyenzeka ngokwemvelo ye-polysaccharide etholakala ezindongeni zeseli zezitshalo. I-cellulose uqobo lwalo ihlanganiswa khona ama-glucose amayunithi axhumene ndawonye, ​​akha amaketanga amade. I-HPMC itholakala ngokuguqulwa kwamakhemikhali kwe-cellulose, ikakhulukazi ngokusebenzisa amaqembu e-hydroxy namaqembu we-methoxy ne-hydroxypropyly.

Inqubo yokukhiqiza:
Ukukhiqizwa kwe-HPMC kubandakanya izinyathelo eziningana, ukuqala ngokukhishwa kwe-cellulose kusuka kwimithombo yezitshalo enjenge-solip yokhuni noma ama-linterstogi. Lapho nje kukhishwe, i-cellulose ithola ukuguqulwa kwamakhemikhali ukwethula ama-hydroxypropyl kanye namaqembu we-methoxy. Le nqubo ivame ukubandakanya ukwelashwa nge-Alkali, ilandelwe ukusheshisa kusetshenziswa i-propelene oxide ne-methyl chloride.

Ngesikhathi sokuthezeka, kwethulwa amaqembu e-hydroxypropyl ukudlulisa ukudlulisela i-soubity yamanzi nezinye izakhiwo ezifiselekayo ku-molecule ye-cellulose. Ngakolunye uhlangothi, amaqembu, ngakolunye uhlangothi, anikela ngokuqina okuphelele nokubonakala kwe-HPMC ephumela. Izinga lokufaka esikhundleni (DS) se-hydroxypropyl kanye namaqembu we-methoxy angalawulwa ukuze ahambisane nezakhiwo ze-HPMC ngezinhlelo ezithile.

3.Plant-based imvelo ye-HPMC:
Njengoba kunikezwe ukuthi i-HPMC isuselwa ku-cellulose, etholakala kakhulu emithonjeni yezitshalo, isekelwe ngokusekelwe kwimvelo. Izinto ezisetshenziswayo ezisetshenziswayo ezisetshenziselwa ukukhiqizwa kwe-HPMC-Wood Pulp kanye nama-Likerston COTRTERS - athathwe ezitshalweni. Ngokungafani namanye ama-polymers noma izengezo ezingatholwa emikhiqizweni yezilwane, njenge-gelatin noma ama-waxes athile, i-HPMC ayinazo izithako ezithathwe zezilwane.

Ngaphezu kwalokho, i-HPMC ihlangabezana nezindlela zokuthi zithathwe njenge-vegan-friendly kanye nemifino, njengoba kungabandakanyi ukusetshenziswa kwezinto zokwakha ezivuthiwe zezilwane noma izinsiza zokucubungula. Lesi sici sibaluleke kakhulu kubathengi abalandela ukudla okusekwe ezitshalweni noma banokucatshangelwa kokuziphatha maqondana nokusetshenziswa kwemikhiqizo yezilwane.

4.Izicelo nezinzuzo:
Isimo esisuselwa kwisitshalo se-HPMC sinomthelela ekwamukelweni kwaso okubanzi futhi sisebenzise kuzo zonke izimboni ezahlukahlukene. Emkhakheni wezemithi, i-HPMC isetshenziswa kakhulu njenge-excipietietical desipunt e-Oral DoSAGE amafomu afana namathebulethi, amaphilisi kanye nokumiswa. Amandla awo okwenza ama-gels azinzile, alawule ukukhishwa kwezidakamizwa, futhi athuthukise ukuhlukaniswa kwethebhulethi kwenze kube isithako esibalulekile ekusungulweni kwemithi.

Embonini yokudla, i-HPMC isebenza njengesikhulu, i-stabilizer, kanye ne-emulsifier emikhiqizweni ehlukahlukene, kufaka phakathi izimpahla ezibhakiwe, ezinye izindlela zobisi, iziphuzo. Imvelaphi yayo esekwe esitshalweni iqondanisa nesidingo somthengi esikhulayo sezithako zemvelo nezinzile emikhiqizweni yokudla.

I-HPMC ithola izinhlelo zokusebenza ezintweni zokwakha, lapho isetshenziswa khona njenge-Rheology modifier, i-ejenti yokugcinwa kwamanzi, nokunamathela emikhiqizweni efana nodaka, ama-plasters kanye nama-tile anamathela. Imvelo yayo esekwe esitshalweni yenza kube ukukhetha okukhangayo kwemikhuba yokwakha eyakha imvelo.

I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano eguquguqukayo ethathwe ku-cellulose, isakhi semvelo sezindonga zeseli zezitshalo. Inqubo yayo yokukhiqiza ifaka ukuguqulwa kwamakhemikhali kwe-cellulose ekhishwe emithonjeni yezitshalo, okwenza kube ngokusekelwe ku-Integra. Ngenxa yalokhu, i-HPMC ilungele ukusetshenziswa emikhakhelweni ehlukahlukene, kufaka phakathi amakhemikhali, ukudla, kanye nokwakha, lapho imvelaphi yayo esekwe esitshalweni ivumelanisa nokuthathwa kwezithako zabathengi ngezithako zemvelo nezinzile. Ngokuqonda ubuhlobo obususelwa kwisitshalo se-HPMC, abakhiqizi kanye nabathengi ngokufanayo bangenza izinqumo ezinolwazi ezisekela amanani abo kanye nezinhloso zokusimamisa.