I-Hydroxypropylyth methyl cellulose HPMC, eyaziwa nangokuthi i-hydroxypromellose, i-white cellulose ether powder noma i-granule enamakhaza amanzi angenayo kanye nokungafakwa emanzini okushisayo okufana ne-methyl cellulose. I-Hydroxypropyl Group ne-Methyl Group yi-ether bond kanye ne-anhydrous glucose ring ye-cellulose kuhlangene, uhlobo lwe-ether exubile exubile. Kuyinto esetshenziswayo, engasebenzi, i-polymer esetshenziswayo esetshenziswa kakhulu njengokuthambisa ku-ophthalmology, noma njenge-excipient noma i-excipoint emithini yomlomo.
1. Inqubo yokukhiqiza
I-Pulp ye-Kraft enokuqukethwe kwe-αcellulose ka-97%, i-intercutic viscosity ye-720ml / g kanye nobude obumaphakathi wefiber e-2.6mm bafakwe emanzini angama-49% kumasekhondi angama-40 ℃ ngemizuzwana engama-40. Ngemuva kwalokho ipulp ikhishwe ukususa isisombululo sika-49% we-naoh ngokweqile ukuze uthole i-alkali cellulose. Isilinganiso sesisindo se (49% naoh aqued solution) ku- (Ingxenye eqinile ye-pulp) esigabeni sokucwilisa kwakungu-200. Isilinganiso sesisindo sikaNaoh e-Alkali Cellulose ukuqina ku-1.49. Ngakho-ke i-Alkali Cellulose etholakele (i-20kg) ibekwa endabeni yengcindezi yengcindezelo ngokuphazamiseka kwangaphakathi, yabe isinwebeka futhi yahlanzwa kanye ne-nitrogen ukususa ngokwanele umoya-mpilo kusuka ku-reactor. Ngemuva kwalokho, izinga lokushisa elikuphendukayo lalilawulwa ngo-60 ℃ ngenkathi kwenziwa okuvuselelwa kwangaphakathi.
Ngemuva kwalokho kwangezwa i-2.4kg DME kanti izinga lokushisa eliku-reactor lalilawulwa libe ngu-60 ℃. Ngemuva kokuhlanganiswa kwe-dimethyl ether, i-methylene chloride yengezwa ukwenza isilinganiso se-molar se-methylene chloride ukuya ku-naoh e-Alkaliolide i-oxide i-pulp 197, futhi izinga lokushisa elikuphendukayo lalilawulwa lisuka ku-60 ℃ kuya ku-80 ℃. Ngemuva kokungeza i-chloromethane ne-propelene oxide, izinga lokushisa elikuphendukayo lalilawulwa kusuka ku-80 ℃ kuya ku-90 ℃. Ngaphezu kwalokho, ukusabela kwahlala imizuzu engama-20 ku-90 ℃.
Igesi selikhishwe kwi-reactoror kanye ne-crude hydroxypropproppropyllllylyl methyl cellulose isuswa kwi-reactioc. Izinga lokushisa le-crude hydroxypropyllllylyl methyl cellulose lalingu-62 ℃. Kala usayizi we-50% we-50% wezinhlayiyana kokusatshalaliswa kwesisindo esisezingeni eliphansi ngokususelwa ku-ratio ye-crude hydroxypropyllllylyl methylyllllylyl methylyllllylylm methylllopyllll methylllopyllllypropylllylyl methylsylllylyl methylllopyllllyryl methylsylllll methylslopylllll methylsyllll methylllelllllm methyl pueltuleose ngokuvuleka kokufikelwa okuhlanu, ngakunye nginosayizi ohlukile wokuvula.
Ngenxa yalokho, ubukhulu obuphakathi kwezinhlayiyana kwezinhlayiyana ezihlanganayo kwakungu-6.2mm. I-methylsproserproperlopyproselrlyllopyllopyrllylylyl yethulwe ku-biaxial Knuder (LRC Konder S1, L / D = 10.2, ivolumu yangaphakathi 0.12, i-Crude Hydroxypropylylylylylylylylylylylylylylylylylylylyly perful. Njengomphumela wezilinganiso ezifanayo usebenzisa izikrini ezi-5 ezinosayizi ohlukile wokuvula, ubukhulu bezinhlayiyana ezijwayelekile kwakungu-1.4mm. Ukungeza Amanzi Ashisayo angama-80 Inani lesilinganiso sesisindo se-crude hydroxyproppropylylylylylylylylylylyl methyl kunani eliphelele le-slurry lingu-0.1, bese kutholakala ama-slurry. I-slurry yathuthukiswa emazingeni okushisa ahlala njalo angama-80 ℃ imizuzu engama-60.
Ngemuva kwalokho, i-slurry inikezwa ngejubane elijikelezayo le-0.5 RPM kanye nesihlungi se-Rotary Pressure evuthayo yangaphambi kwalokho (imikhiqizo ye-dlionthofen). Izinga lokushisa le-grout lingu-93 ℃. Sebenzisa iphampu ukuze unikeze ama-slurry, ukukhishwa kwempumputhe kungu-0.2MPA. Usayizi wokuvula wesihlungi sengcindezi ejikelezayo yi-80μm, kanti indawo yokuhlunga ingu-0,12m2. I-slurry enikezwe isihlungi se-Rotary Pressure ihlungwa ngokusebenzisa isihlungi bese iguqulwa ibe yikhekhe lokuhlunga. Ikhekhe lokuhlunga eliphumela liyanikezwa umusi ongu-0,3mpa kanye namanzi ashisayo angu-95
Amanzi ashisayo anikezwa ngephampu ekucindezelweni kwe-0.2MPA. Ngemuva kokuthi amanzi ashisayo ahlinzekwa, i-0.3MPA Steam iyanikezwa. Ngemuva kwalokho, ngemuva kokuba imikhiqizo yokuwasha isuswa endaweni yokuhlunga yi-scraper futhi ikhishwe ngaphandle komshini wokuwasha. Izinyathelo ezivela ekunikezelweni kwe-slurry ukuhambisa imikhiqizo egeziwe kwenziwa ngokuqhubekayo. Njengoba kulinganiswe kusetshenziswa ukushisa - ukomisa i-hygrometer, okuqukethwe kwamanzi komkhiqizo ogeziwe ngakho-ke kukhishwe kwakungu-52.8%. Imikhiqizo egeziwe ikhishwe kusuka kuhlu lokucindezela kwe-Rotary yomiswe ngosomisi womoya ngo-80 ℃, futhi ichotshozwe esigangeni sokunqoba ukuthola i-hydroxypropylylylylylylylylylylylylylylylylylyly methyl.
-Makhekilizelaukuhlasela
Umkhiqizo we-HPMC usetshenziswa njenge-persener, ehlakazekile, i-binder, emulsifier ne-spintizer embonini yezindwangu. Isetshenziswa kabanzi ku-resin zokwenziwa, i-petrochemical, ceramic, iphepha, isikhumba, umuthi, ukudla, izimonyo kanye nezinye izimboni.
Isikhathi sePosi: Mar-23-2022