Ifilimu le-Hydroxypropylm methylcellulose (HPMC) linokusebenza okuhle kakhulu, kepha ngoba i-HPMC yijeli eshisayo, i-viscosity emazingeni aphansi iphansi kakhulu, engakuhlehlisi ekulweni kwamazinga aphansi, okuholela ekusebenzeni kahle; Ngaphezu kwalokho, izindleko zayo eziphakeme zikhawulela ukusetshenziswa kwayo. I-Hydroxypropyl starch (HPS) i-gel ebandayo ebiza kakhulu, ukwengeza kwayo kungakhuphula ukubonwa kwe-HPMC ngamazinga aphansi, futhi kunciphise ukusebenza kwe-hpmc, futhi kunciphise i-hydrophilicity, ama-glucose nama-hydroxypropylys wonke anikela ekuthuthukiseni ama-polymers amabili. Ngakho-ke, uhlelo olukhazimulayo lwe-Gel Blend lwalungiswa yi-HPS ehlanganisiwe futhiI-HPMC, kanye nomphumela wokushisa kwesakhiwo se-gel sohlelo lwe-HPMC / HPS olubandayo lwe-GEL CEL Blend lwalufundwa ngokuhlelekile ngokusebenzisa amasu we-rheometer kanye namasu amancane we-X-ray aked. , kuhlanganiswe nethonya lezimo zokwelashwa kokushisa ku-microssCreature kanye nezakhiwo zohlelo lwe-membrane, bese zakha ubudlelwano phakathi kwesakhiwo sejeli sohlelo lokuhlanganisa uhlelo-membrane ngaphansi kwezimo zokwelashwa okushisa.
Imiphumela ikhombisa ukuthi ekushiseni okuphezulu, ijeli enokuqukethwe okuphezulu kwe-HPMC ine-modulus ephezulu kanye nokuziphatha okuqinile okucatshangelwa ngokwengeziwe, ukwakheka okufanayo kwabahlakazi bakaGeli kukhulu; Emazingeni okushisa aphansi, okuqukethwe kwe-HPS okuphezulu kwamasampula aphezulu anezindlela eziphakeme ze-modulus, ukuziphatha okuqinile okuqinile ngokwengeziwe, nesakhiwo esifanayo esifanayo sabahlakazeke. Kumasampula anesilinganiso esifanayo esijabulisayo, i-modulus kanye nokuziphatha okuqinile okubalulekile nobuningi besakhiwo esifanayo bama-gels aphethwe yi-HPMC ekushiseni okuphezulu kunalawa amazinga okushisa aphansi. Ukushisa okulomile kungathinta ukwakheka kwe-gel kohlelo ngaphambi kokoma, bese kuthinta isakhiwo se-crystalline kanye nesakhiwo sefilimu, futhi ekugcineni kube nomthelela obalulekile kwizakhiwo zemishini kanye nemodulomu yefilimu eyomile ekushiseni okuphezulu. Ephakeme kunomile emazingeni okushisa aphansi. Izinga lokupholisa alinamphumela osobala esakhiweni se-crystalline sohlelo, kepha lunomthelela ebuntwini bomzimba wefilimu ofana ne-microdomain. Kulesi simiso, ubukhulu besakhiwo esifanayo sefilimu bungathinta izakhiwo zemishini zefilimu. Ukusebenza kunomthelela omkhulu.
Ngokusekelwe ekuhlelweni kolwelwesi oluhlanganisiwe, isifundo sathola ukuthi ukusetshenziswa kwe-iodine solution ukuze udaye ulwelwesi olusha lwe-HPMC / HPS kusungula indlela entsha yokubukela ukusatshalaliswa kwesigaba nokuguqulwa kwesigaba sohlelo oluhlanganisiwe ngaphansi kwesibonasi. Indlela, enokubaluleka kokuqondisa kwendlela endleleni yokucwaninga kokusatshalaliswa kwesigaba kwezinhlelo ezihlanganisiwe zesitashi. Usebenzisa le ndlela entsha yocwaningo, ehlanganiswe ne-spectroscopy ye-infrared, ukuskena i-elektroni microscopy kanye ne-extensometer, ukuguqulwa kwesigaba, ukuhambisana kanye nezindawo zohlelo zihlaziywa futhi zihambisane, ukuguqulwa, ukuguqulwa kwesigaba kanye nokubukeka kwefilimu kwakhiwa. ubudlelwane phakathi kokusebenza. Imiphumela yokubheka amacroscope ibonisa ukuthi uhlelo lubhekene noshintsho lwesigaba lapho isilinganiso se-HPS singama-50%, futhi into yokuxubana ye-Interphase ikhona kwifilimu, okukhombisa ukuthi uhlelo lunethuba elithile lokuhambisana; I-infrared, ukuhlaziya kwe-thermogravimetric kanye nemiphumela ye-SEM kuqinisekisa ukuhlanganiswa. Uhlelo lunezinga elithile lokuhambisana. I-modulus yefilimu ehlanganisiwe ishintsha lapho okuqukethwe kwe-HPS kungama-50%. Lapho okuqukethwe kwe-HPS kukhulu kune-50%, i-angle yokuxhumana yesampula ehlanganisiwe ivela kulayini oqondile oxhumanisa ama-engeli okuxhumana amasampula amsulwa, futhi lapho ingaphansi komugqa oqondile. , okubangelwa ikakhulu ukuguqulwa kwesigaba.
Isikhathi sePosi: Oct-19-2022