Kuthatha isikhathi esingakanani i-HPMC ichithe?

I-HPMC (i-Hydroxypropyl Methylcellulose) iyi-polymer evame ukusetshenziswa esetshenziselwa ukulungiswa kwamathebulethi omakhemikhali, amaconsi wamehlo neminye imikhiqizo. Isikhathi sayo sokuchithwa sincike ezicini eziningana, kufaka phakathi isisindo samangqamuzana, izinga lokushisa lesisombululo, isivinini esishukumisayo kanye nokuhlushwa.

1. Isisindo samangqamuzana kanye nezinga lokufaka esikhundleni
Isisindo samangqamuzana kanye nezinga lokufaka esikhundleni (okusho, okuqukethwe kwe-methoxy kanye ne-hydroxypropyl) ye-HPMC izothinta i-solubity yayo. Ngokuvamile, ubukhulu besisindo se-molecular, kuthatha isikhathi eside ukuncibilikisa. I-viscositi ephansi i-HPMC (isisindo esiphansi samangqamuzana) imvamisa ithatha imizuzu engama-20- 40 ukuncibilikisa izinga lokushisa lasekamelweni, kuyilapho i-viscosity ephezulu i-HPMC (isisindo esiphakeme) ingathatha amahora amaningi ukuncibilikisa ngokuphelele.

2. Ukushisa kwesisombululo
Izinga lokushisa lekhambi linomthelela omkhulu kwizinga lokuchithwa kwe-HPMC. Amazinga okushisa aphezulu avame ukusheshisa inqubo yokuqothula, kepha amazinga okushisa aphezulu kakhulu angabangela ukonakala kwe-HPMC. Ukuvikelwa kokuqothuka okunconywa ngokuvamile kuphakathi kuka-20 ° C no-60 ° C, kanye nokukhetha okuthile kuncike ezicini ze-HPMC nenhloso yokusebenzisa.

3. Ijubane elishukumisayo
Ukuvuselela kungakhuthaza ukuchithwa kwe-HPMC. Ukuvuselela okufanele kungavimba i-agglomeration ne-velipation ye-HPMC futhi kwenze kube nokuhlakazeka ngesisombululo. Ukukhethwa kwesivinini esishukumisayo kufanele kulungiswe ngokuya ngemishini ethile kanye nezimpawu ze-HPMC. Ngokuvamile, imiphumela egculisayo ingatholakala ngokuvusa imizuzu engama-20- 40.

4. Ukuhlushwa Isixazululo
Ukuhlushwa kwe-HPMC nakho kuyinto ebalulekile ekunqumeni isikhathi sayo sokuqothula. Lapho kukhula khona okuhlushwa, isikhathi eside ukuchitheka isikhathi eside. Ngokuhlushwa okuphansi (<2% w / w) izixazululo ze-HPMC, isikhathi sokuqothula kungenzeka sibe mfushane, ngenkathi izixazululo zokuhlushwa eziphakeme zidinga isikhathi esengeziwe sokuncibilikisa.

I-5. Ukukhetha kwe-solvent
Ngaphezu kwamanzi, i-HPMC ingahle ichithwe kwamanye ama-solvents anjenge-ethanol ne-ethylene glycol. I-polarity kanye ne-solubility ye-solvents ehlukene kuzothinta izinga lokuchithwa kwe-HPMC kanye nezimpawu zesisombululo sokugcina.

6. Izindlela Zokuthola Ukwehluleka
Ezinye izindlela zokubonisa ukwehla, njenge-HPMC yangaphambi kokumanzisa noma ukusebenzisa amanzi ashisayo, kungasiza ukusheshisa inqubo yayo yokuqothula. Ngaphezu kwalokho, ukusetshenziswa kwezinsizakalo zokuqothula ezinjenge-surtactants nazo zingathuthukisa ukusebenza kahle.

Isikhathi sokuchithwa kwe-HPMC siyathinteka ezintweni eziningi. Ngakho-ke, kuzinhlelo zokusebenza ezisebenzayo, izimo zokuqothula kufanele zilungiswe ngokuya ngezidingo ezithile zokusetshenziswa kanye nezimpawu ze-HPMC. Imvamisa, isikhathi esidingekayo ku-HPMC ukuthi sincibilike ngaphansi kwezimo ezifanele zisukela emizuzwini engama-30 ziye emahoreni ambalwa. Ngemikhiqizo ethile ye-HPMC kanye nezimo zohlelo lokusebenza, kunconywa ukubhekisa kwimiyalo yomkhiqizo noma izivivinyo zokuzihlola ukuthola izimo eziphelele zokuqothula nesikhathi.