Zisetshenziswa kanjani izimpi ze-cellulose embonini yezemithi?

I-Cellulose Afers isetshenziswa kabanzi embonini yezemithi, futhi izakhiwo zazo ezihlukile zomzimba nezamakhemikhali zizenza zibe yingxenye ebalulekile yezinhlobonhlobo zamalungiselelo amakhambi.

1. Amalungiselelo wokukhishwa alawulwayo futhi aqinisekayo
I-Cellulose Teshers, efana ne-hydroxypropyll methylcellose (HPMC) ne-sodium carboxyyllls (CMC-N), zivame ukusetshenziselwa ukulawula isilinganiso sokukhishwa kwezidakamizwa. Bangakha ungqimba lwe-gel ukwelula isikhathi sokukhishwa kwezidakamizwa ngokulawula izinga lokuphazamiseka kanye nezinga lokuchithwa kwezidakamizwa. Ngokusebenzisa i-cellulose izithathathi ezine-visosities ehlukene nama-degrees okufaka esikhundleni, inani lokukhishwa kwezidakamizwa emzimbeni lingaba elawulwa ngokunembile, ngaleyo ndlela lithuthukise ukusebenza kwezidakamizwa futhi kuncishiswe imvamisa yemithi.

2. Ukwakheka kwamakhabethe namathebulethi
AbakwaCellulose Abapholile badlala indima ebalulekile enqubweni yokukhiqiza yamathebulethi kanye nama-capsule njengezixhumanisi kanye nokwakha ama-ejenti. I-HPMC ne-CMC-NA zivame ukusetshenziswa njengezihlangene zokuthekezela okuqondile ngenxa yoxhaso lwazo oluhle nokuxinana. Bangakhulisa ubulukhuni nokuqina kwamathebulethi, bathuthukise amandla emishini yamathebulethi, futhi baqinisekise ukuhlukaniswa okufanele kwamathebulethi asephepheni lesisu.

3. Abakhulu kanye nabaqinisile
I-Cellulose Afers isetshenziswa njengabakhulu kanye nokuzimisela kumalungiselelo owuketshezi. Bangakhuphula ukubonwa kwesixazululo futhi bathuthukise ukumiswa nokuqina kwesidakamizwa. Isibonelo, i-CMC-NA ivame ukusetshenziselwa ukumiswa komlomo kanye nokhilimu ophezulu ukuvikela ukudonswa kwezithako kanye nokuhlukaniswa kwezithako zezidakamizwa, ngaleyo ndlela kuthuthukise ukufana nokuzinza kokulungiswa.

4. Izinto zokwakha ze-Enteric Coating
I-Cellulose Afers ethile, efana ne-ethyl cellulose (EC), imvamisa isetshenziswa ezintweni zokwenziwa ze-Enteric Coatic ngenxa yokubekezelela kwabo ezindaweni ezinomdlandla. Izambatho ze-ENTERIC zingavikela umuthi ekuboleni i-gastric acid futhi ukhulule lesi sidakamizwa emathunjini. Lokhu kungavimba isidakamizwa ukuthi singabhujiswa esiswini futhi sithuthukise ukungatholakali kwesidakamizwa.

I-5. Izinto ze-Biodhesive
AbakwaCellulose Abathambekele benganamathela ngolwelwesi lwebhayoloji, olubenza lube lubalulekile lapho kulungiswa amalungiselelo e-bioaphesive. Amalungiselelo we-Biathesive anganweba isikhathi sokuhlala sezidakamizwa esizeni sendawo futhi andise ukuhlanganiswa kwezidakamizwa, ngaleyo ndlela ethuthukisa ukusebenza kahle kwezidakamizwa. Isibonelo, i-HPMC ivame ukusetshenziswa kumalungiselelo we-ophthalmic kanye namalungiselelo omlomo we-mucosal, okungakhulisa isikhathi sokuhlala sezidakamizwa e-ocular ebusweni nase-mucosa yomlomo.

6. I-coating impahla
I-Cellulose Afers ivame ukusetshenziswa njengezinto zokwakha zokulawula izici zokukhishwa kwezidakamizwa futhi zithuthukise ukuqina kwezidakamizwa. I-Cellulose Ether Coatings ingavikela izidakamizwa emathonyeni angaphandle ezemvelo, anjengomswakama nomoya-mpilo, futhi anwebe impilo yeshelufu yezidakamizwa. Ngaphezu kwalokho, ngokulungisa ubukhulu be-coation kanye nokwakheka, umuthi ungadedelwa ngesikhathi esinqunyelwe nangendlela eqondisiwe.

7. Abathuthukisi kanye nama-ejenti asolisayo
Kwamanye amalungiselelo ayinkimbinkimbi wezidakamizwa, izithambiso ze-cellulose zingasetshenziswa njengezikhundla kanye nama-ejenti okumisa ukuthuthukisa ukusebenza kahle nokuqina kwezidakamizwa. Isibonelo, ezingxoxweni ezijobelayo kanye nokufakwa kwe-infunous, izithambiso ze-cellulose zingavimba ukunqunyelwa kwezinhlayiya zezidakamizwa futhi kuthuthukise ukufana nokuqina kwesisombululo sezidakamizwa.

8. Ama-Excipie esebenzayo
I-Cellulose Afers nayo isetshenziselwa ukulungiselela ama-Excipients asebenzayo, anjengamathebulethi asuswa ngokushesha namathebulethi okukhishwa okuqhubekayo. Lezi zinto ezithokozisayo zingalungisa izinga lokuchithwa futhi zikhulule izici zezidakamizwa, zithuthukise ukuqina kwezidakamizwa nokulandela iziguli. Isibonelo, i-HPMC isetshenziswa kabanzi ukulungiselela amaphilisi asuswa ngokushesha, angahlukaniswa ngokushesha ngemuva kokuxhumana namanzi, okwenza kube lula ukuthi iziguli zithathe.

9. Ukuqina nokuphepha
I-CelluleOse Ether inokuqina okuhle nokuphepha, futhi ingahle ifakwe ku-watabolized ibe yizinto ezilimazayo emzimbeni, ukunciphisa imiphumela emibi emzimbeni womuntu. Ngakho-ke, i-cellulose ether isetshenziswa kabanzi embonini yezemithi futhi iye yaba yinto enhle enhle yokulungiselela izidakamizwa ezahlukahlukene.

Ukusetshenziswa kwe-cellulose ether embonini yezemithi kuhlanganisa ukukhishwa okulawulwayo kanye nokukhishwa kwe-capsule kanye nokuqiniswa kwethebhulethi, izinsiza ze-Enteric coative, izinsiza ze-biodiosive, ama-synergists kanye nama-ejenti asolisayo. Izakhiwo zayo ezihlukile zenyama nezamakhemikhali zikwenza kube yisithako esibaluleke kakhulu futhi esibalulekile kumalungiselelo emithi, okukhuthaze kakhulu ukuthuthukiswa kobuchwepheshe bezemithi kanye nokwenza ngcono ukusebenza kwezidakamizwa.