Izici ezithinta impilo yeshelufu ye-HPMC

I-Hydroxypropyl Methylcellulose (HPMC) yinto yamakhemikhali yamakhemikhali asetshenziswa kakhulu emithi yemithi, ukudla, izimonyo kanye nezinto zokwakha. Impilo yayo yeshelufu ibhekisela ngobude besikhathi ingagcina izakhiwo zayo zomzimba, zamakhemikhali nezisebenzayo ngaphansi kwemibandela ethile. Izici ezithinta impilo yeshalofly ye-HPMC zifaka izimo zemvelo, izimo zokugcina, ukuqina kwamakhemikhali, njll.

1. Izimo zezemvelo
1.1 izinga lokushisa
Ukushisa kungenye yezinto ezibalulekile ezithinta impilo yeshelufu ye-HPMC. Izinga lokushisa eliphakeme lizosheshisa ukusabela kokuwohloka kwe-HPMC, okuholela ekushintsheni kwezici zalo zomzimba nangamakhemikhali. Isibonelo, i-HPMC ingaphenduka i-Yellow futhi inciphise ukubonakala kwayo ekushiseni okuphezulu, okuthinta ukusebenza kwayo. Ngakho-ke, izinga lokushisa elizwakalayo lapho i-HPMC igcinwa khona kufanele igcinwe emazingeni okushisa aphansi, ngokuvamile ngaphansi kuka-25 ° C, ukwelula impilo yayo eshalofini.

1.2 umswakama
Umphumela womswakama ku-HPMC ubaluleke ngokulinganayo. I-HPMC iyinto esetshenziselwa i-hydrophilic polymer edonsa kalula umswakama. Uma umswakama endaweni yokugcina indawo ephakeme kakhulu, i-HPMC izodonsa umswakama emoyeni, okwenza ukubonakala kwayo kuguqulwe, i-solubity yayo yehle, futhi ngisho nokuvuselelwa kwenzeke. Ngakho-ke, i-HPMC kufanele igcinwe yomile lapho igcinwa, futhi kunconywa ukuthi umswakama ohlobene ulawulwe ngaphansi kwama-30%.

2. Izimo zokugcina
2.1 Ukupakishwa
Izinto zokupakisha nokubopha uphawu kunomthelela oqondile empilweni yeshelufu ye-HPMC. Izinto zokufaka ezisezingeni eliphakeme zingahlukanisa umoya nomswakama futhi zivikele i-HPMC ekutholeni imanzi futhi ziye. Izinto ezisetshenziswayo ezisetshenziswayo zifaka izikhwama ze-aluminium foil, izikhwama ze-polyethylene, njll., Ezinezindawo ezinhle zokuvimba. Ngasikhathi sinye, ukupakishwa okuvalwe kahle kunganciphisa ukuxhumana kwe-HPMC ngemvelo yangaphandle futhi kunwebe impilo yayo eshalofini.

2.2 ukukhanyisa
Ukukhanya, ikakhulukazi i-ultraviolet irradiation, kungadala ukonakala kwe-PhotoOxidation kwe-HPMC futhi kuthinte izakhiwo zayo zomzimba nezamakhemikhali. Uma kuvezwa ukukhanya isikhathi eside, i-HPMC ingashintsha umbala, ukuqhekeka kombala, njll. Ngakho-ke, i-HPMC kufanele igcinwe endaweni ebonakalayo ebufakazi noma usebenzise izinto zokupakisha ze-opaque.

3. Ukuqina kwamakhemikhali
3.1 Ivelu ye-PH
Ukuqina kwe-HPMC kuthinteka kakhulu ngenani le-PH. Ngaphansi kwezimo ze-acidic noma ze-alkali, i-HPMC izobhekana ne-hydrolysis noma ukucekelwa phansi, okuholela ezinkingeni ezinjengokuncipha okubonakalayo kokubonakala kanye noshintsho e-solubity. Ukuze uqinisekise ukuqina kwe-HPMC, kunconywa ukuthi inani le-PH lekhambi layo lilawulwa ngaphakathi kwebanga elingathathi hlangothi (PH 6-8).

3.2 Ukungcola
Ukuba khona kokungcola kuthinta ukuqina kwamakhemikhali kwe-HPMC. Isibonelo, ukungcola okufana ne-metal ion kungahle kunciphise ukusabela okuwonakalisiwe kwe-HPMC, kunciphise impilo yayo eshalofini. Ngakho-ke, okuqukethwe ukungcoliseka kufanele kulawulwe ngokuqinile ngesikhathi senqubo yokukhiqiza kanye nezinto zokwakha eziphakeme kakhulu kufanele zisetshenziselwe ukuqinisekisa ubumsulwa be-HPMC.

4. Ifomu lomkhiqizo
Ifomu lomkhiqizo le-HPMC lithinta impilo yalo eshalofini. I-HPMC imvamisa ikhona ngendlela ye-powder noma ama-granule. Umthelela wamafomu ahlukene ngempilo yalo yesheletimemi ngokulandelayo:

Ifomu le-4
Ifomu le-HPMC le-powder linendawo enkulu yendawo ethile futhi i-hygroscopic kalula futhi ingcolisiwe, ngakho-ke impilo yayo yeshelufu ifushane. Ukwelula impilo yeshelufu ye-HPMC eyimpuphu, ukufakwa okuvaliwe kufanele kuqiniswe ukugwema ukuxhumana nomoya nomswakama.

I-4.2 Particle morphology
Izinhlayiya ze-HPMC zinendawo encane engaphezulu komhlaba, ziyi-hygroscopic encane, futhi zinempilo eshalofini ende. Kodwa-ke, i-HPMC ehleliwe ingakhiqiza uthuli ngesikhathi sokugcina nokuhamba, okuholela empilweni efushaniwe eshalofini. Ngakho-ke, i-HPMC ye-Granur futhi idinga ukufakwa okuhle nokugcina izimo.

5. Sebenzisa izengezo
Ukuze uthuthukise ukuqina futhi unwebe impilo eshalofini ye-HPMC, abangabathentu noma ama-preservatives angangezwa ngesikhathi sokukhiqiza. Isibonelo, ukungeza ama-antioxidants kungavimbela ukonakaliswa kwe-oxidative of HPMC, futhi wengeza ama-agents wokufakazela umswakama anganciphisa i-hpgroscopicity ye-HPMC. Kodwa-ke, ukukhethwa kanye nemithamo yezithasizo kudinga ukuqinisekiswa ngokuqinile ekuqinisekiseni ukuthi azithinti izakhiwo ezisebenzayo nokuphepha kwe-HPMC.

Impilo eshalofini ye-HPMC ithintwa yizinto eziningi, kufaka phakathi izimo zemvelo (izinga lokushisa, umswakama (ukufakwa, ukulimala), ukuqina kwamakhemikhali (inani le-PH, ukungcola) kanye nokusetshenziswa kwezithasiselo. Ukuze unwebe impilo yeshelufu ye-HPMC, lezi zinto kufanele zithathwe njengezinyathelo eziphelele futhi kufanele zithathwe ukuze zilawulwe. Isibonelo, gcina indawo yokugcina ephansi nesezingeni eliphakeme, sebenzisa isisombululo esisezingeni eliphakeme, ukunciphisa okuqukethwe ukungcola, njll. Ngokuphatha ngokwesayensi kanye nokugcinwa kwe-HPMC kunganwetshwa ngempumelelo futhi ukusebenza kwawo emikhakheni ehlukahlukene kungaqinisekiswa.