The solubility of hydroxypropyl methylcellulose (HPMC, Hydroxypropyl Methylcellulose) is affected by many factors, including its physical and chemical properties, solvent conditions and external environment. Lezi zinto zibaluleke kakhulu ekusetshenzisweni kwe-HPMC kanye nokusebenza kwayo eMkhemeni, Ukudla, Kwezokwakha kanye Nezinye Izimboni.
1. Izakhiwo zenyama nezamakhemikhali
1.1 isisindo molecular
Isisindo samangqamuzana se-HPMC siyisici esibalulekile esithinta i-solubity yayo. Ngokuvamile, ubukhulu besisindo samangqamuzana, okuhamba kancane izinga lokuchithwa. Lokhu kungenxa yokuthi isisindo esikhulu se-molecular siphumela emaketangeni ama-molecular amangalisayo, okukhulisa ukuheha kanye nokusebenzisana phakathi kwama-molecule, ngaleyo ndlela kunciphise inqubo yokuchitheka. Ngokuphambene nalokho, i-HPMC enesisindo esincane samangqamuzana inciphisa ngokushesha, kepha ukubonwa kwayo kwesixazululo kungase kuncishiswe, kwenziwe kungakulungeli ezinye izinhlelo.
1.2 degree yokufaka esikhundleni
Izinga lokufaka esikhundleni se-HPMC (okungukuthi isikhundla sokufakwa esikhundleni se-methoxy ne-hydroxypropoxy) futhi lithinta kakhulu i-solubity yalo. I-HPMC ene-degree ephezulu ye-methoxy ne-hydroxypropoxy imvamisa ivame ukuba ne-soubity engcono emanzini ngoba laba bantu bangakhulisa i-hydrophicity ye-molecule futhi ithuthukise i-hydration. Kodwa-ke, ukufaka esikhundleni ngokweqile kungaholela ekunciphiseni kwe-solubility ye-HPMC kuma-solvents athile, okuhlobene nobumbano lwe-solvent kanye nokuxhumana kwamangqamuzana.
1.3 usayizi wezinhlayiyana
Ubukhulu bezinhlayiyana be-HPMC bunomthelela oqondile ngezinga lazo lokuchithwa. Uma omncane usayizi wezinhlayiyana, kukhudlwana indawo ethile engaphezulu kwevolumu ngayinye yeyunithi, futhi indawo evezwe yi-solvent iyanda, ngaleyo ndlela isheshise inqubo yokuchitheka. Ngakho-ke, i-HPMC ngefomu elimnandi le-powder livame ukuncibilika ngokushesha kunefomu elinama-granular.
2. Izimo ze-solvent
2.1 Uhlobo lwe-solvent
I-solubity ye-HPMC iyahluka kakhulu kuma-solvents ahlukene. I-HPMC ine-soubity enhle emanzini, ikakhulukazi amanzi afudumele. I-solvents engalungile efana ne-ethanol, i-propylene glycol, i-ethylene glycol, njll. Ingancibilikisa i-HPMC, kepha ijubane lokuchithwa kanye ne-solubity kuvame ukwehlisa ukwedlula amanzi. Ngokuxuba izingxube ze-solvent, ukuSolubeni) kuya ngezilinganiso zezingxenye nokuxhumana kwazo nge-HPMC.
Ukushisa kwe-2.2
Ukushisa kunomthelela omkhulu ekuhlanyeleni kwe-HPMC. Ngokuvamile, i-HPMC yehla kancane emanzini abandayo, kepha njengoba izinga lokushisa lenyuka, izinga lokuchithwa likhulisa kakhulu, futhi lenze kahle emanzini afudumele ka-40-50 c. Kodwa-ke, emazingeni okushisa aphezulu (imvamisa engaphezu kuka-70 ° C), i-HPMC ingahle iqonde noma yakha ijeli, ehlobene nezinguquko ezakhiweni zayo ze-thermodynamic kanye nesakhiwo sezixazululo.
Inani le-2.3 PH
I-solubity ye-HPMC iqinile ngaphansi kwezimo ezahlukahlukene ze-PH, kepha izimo ze-PH ezibanzi (ezinjenge-acid eqinile noma i-alkali) zingathinta ukuqina kwayo nokuqina kwayo. I-HPMC ngokuvamile ine-soubelity enhle kakhulu ngaphansi kwezimo ezingathathi hlangothi noma eziseduze.
3. Izici zangaphandle zezemvelo
3.1 izimo ezivusa
Ijubane elishukumisayo nendlela inomthelela omkhulu kwijubane lokuchithwa kwe-HPMC. Ukuvuselela okufanele kungakhuthaza ukuxhumana phakathi kwe-HPMC ne-solvent ukugwema ukwakheka kwama-clumps, ngaleyo ndlela kusheshise inqubo yokuchitheka. Kuvuselelwa ngokushesha okukhulu kungadala ama-bubble ukuba asungule, athinte ukufana kwesixazululo.
3.2 ABANDI
Ezinye izengezo kusixazululo, ezinjengosawoti, ama-electrolyte, ama-surfiactants, njll., Kuzothinta i-solubity ye-HPMC. Isibonelo, usawoti othile angakhuthaza ukuchithwa kwe-HPMC, ngenkathi ukugxila okuphezulu kwama-electrolytes kungadala ukushintshwa kwemvula noma i-viscocity ye-HPMC. Ukungezwa kwama-surfactants kungathuthukisa i-solubility ye-HPMC ezinhlamvwini ezithile ezingezona ezinamanzi nokwandisa ukusebenza kwesixazululo.
4. Ukucatshangelwa kohlelo lokusebenza
Imboni yezemithi
Embonini yezemithi, i-HPMC isetshenziswa kabanzi njengezinto ze-matrix kumalungiselelo wokukhulula okuqhubekayo, futhi i-solubeni yayo ithinta ngqo isilinganiso sokukhululwa kanye nokuvunyelwa komuthi. Ngakho-ke, ukulawula isisindo se-molecular, izinga lokufakwa esikhundleni kanye nezimo zokuqothula ze-HPMC zibalulekile ukulungiswa kwamalungiselelo asebenza kahle namakhambi amakhambe.
4.2 Imboni yokudla
Embonini yokudla, i-HPMC isetshenziswa njengesikhulu, i-stabilizer kanye ne-emulsifier. I-solubelity yayo inquma ukusakazwa kwayo, ukuthungwa nokuqina ekudleni. Ngokushintsha izimo zokuqothula, umphumela wohlelo lwe-HPMC ekudleni angalungiswa.
4.3 Imboni Yokwakha
Ezintweni zokwakha, i-HPMC isetshenziswa njenge-ejenti yokugcina amanzi, isikhungo kanye ne-binder, futhi i-solubelity yayo ithinta ukusebenza kokwakha kanye nekhwalithi yokugcina yodaka, izimbotshana neminye imikhiqizo. Ukulungisa izimo zokuqothula kanye nezindlela zohlelo lokusebenza ze-HPMC zingathuthukisa umphumela wokusetshenziswa nokuqina kokuqukethwe.
I-solubity ye-HPMC ithinteke yizakhiwo zomzimba nangamakhemikhali ezifana nesisindo se-molecular, degree of subspere, kanye nobukhulu bezinhlayiya, kanye nezimo zodwa, kanye nezimo ze-solvent ezinjenge-solvent, izinga lokushisa langaphandle. Kuzinhlelo zokusebenza ezisebenzayo, i-solubity kanye nokusebenza okusebenzayo kwe-HPMC kungahle kwenziwe kahle ngokukhetha futhi ngokulawula lezi zinto ngokuya ngezidingo ezithile nezindawo. Ukuqonda okujulile kwalezi zinto kuzosiza ukuthuthukisa umphumela wesicelo se-HPMC ezimbonini ezahlukahlukene futhi kunikeze ukusekelwa kokusungula ubuchwepheshe emikhakheni ehlobene.
Isikhathi sePosi: Feb-17-2025