I-HPMC (i-Hydroxypropyl Methylcellulose) iyingxenye ye-polymer compound esetshenziswa kabanzi kwezokwelapha, ukudla kanye nasembonini. Kwenziwa kusuka kumakhembu wemvelo wemvelo aguqulwe ngamakhemikhali futhi ane-soubelity enhle yamanzi nokuqina. Ngokuqondene nokuthi i-HPMC ingachithwa emanzini ashisayo, idinga ukuhlaziywa ebudlelwaneni phakathi kwezici zayo zokuchithwa kanye nokushisa kwamanzi.
1. Izici zokuchithwa kwe-HPMC
I-HPMC iyi-ether ye-celsuble ye-annoinic enikezela ngamanzi angancibilika emanzini abandayo futhi akha isixazululo esibonakalayo noma esibonakalayo se-colloidal. I-solubelity yayo ithintwe kakhulu izinga lokushisa, eliboniswa ikakhulukazi kulezi zinto ezilandelayo:
Ukushisa okushisa okuphansi: emanzini abandayo (imvamisa ngaphansi kwamanzi angama-40 ° C), izinhlayiya ze-HPMC zingadonsa ngokushesha amanzi nokuvuvukala, kancane kancane zincibilikisa ukwakha isixazululo esifanayo.
Ukuchazwa kwamanzi okushisayo: I-HPMC iyi-insoluble emanzini aphezulu okushisa, kepha ingahlakazeka ukuze yakhe ukumiswa. Lapho amanzi ephola emazingeni okushisa afanele, izinhlayiya ziqala ukuncibilikisa.
2. Ukuncishiswa kokuchithwa emanzini ashisayo
Ukusebenza kwe-HPMC emanzini ashisayo kuhlobene kakhulu nohlelo lokushisa kanye nesixazululo:
Hhayi ngokuqondile emanzini ashisayo: ekushiseni okuphezulu (imvamisa ngaphezulu kwama-60 ° C) izindawo, izinhlayiya ze-HPMC zizosheshe zilahlekelwe yi-solubity futhi zakha isakhiwo senethiwekhi ye-insoluble. Le nto ibizwa nge- "Thermal Gelation", okungukuthi, ama-molecule we-HPMC ahlangana emanzini ashisayo ngokusebenzisa isibopho se-hydrogen se-hydrogen.
Indlela efanelekile yokuchithwa: Faka i-HPMC emanzini ashisayo futhi uvuse kahle ukuze wakhe ukusakazwa okuzinzile. Njengoba amazinga okushisa ehla, into eshisayo ye-gelation iyaphakanyiswa, futhi izinhlayiya zizodonsa amanzi futhi futhi zincibilike kancane kancane.
3. Izindlela zokuqothula kuzinhlelo zokusebenza ezisebenzayo
Ukuze uthuthukise ukusebenza kahle kwe-HPMC kanye nokufana kwesixazululo, izindlela ezilandelayo zivame ukusetshenziswa:
Indlela eshisayo nebandayo yokuxuba amanzi: Okokuqala engeza i-HPMC emanzini ashisayo acishe abe ngu-70 ° C ukugwema ukugwema izinhlayiyana zezinhlayiyana, bese uqhubeka nokuvusa ngesikhathi senqubo yokupholisa kuze kube yilapho kuchithwe ngokuphelele.
Indlela E-Dry Powder Pre-Dispression: Mix HPMC nezinye izimpondo ezi-soluble kalula (ezifana noshukela), bese kancane kancane engeza amanzi abandayo ukuze ancibilike, okungakhuphula ijubane lokuchitheka.
4. Ukuqapha
Gwema amazinga okushisa ngokweqile: I-HPMC ingahle ilahlekelwe yi-soubity ngaphezulu kokushisa kwayo kwe-gelation (imvamisa phakathi kuka-60-75 ° C).
Govuza kahle: Qiniseka ukuthi izinhlayiya zihlakazeka kahle lapho wengeza amanzi ukuvikela ukwakheka kwezigaxa ezingafakwanga.
I-HPMC ayincibiliki ngokuqondile emanzini ashisayo, kepha ingahlakazwa emanzini ashisayo ukwakha ukumiswa, okuzoncibilika ngemuva kokupholisa. Ngakho-ke, indlela efanele yokuqothula ibalulekile ekusebenzeni kwayo. Kuzinhlelo zokusebenza, izimo zokuqothula kufanele zilungiswe ngokuya ngezidingo ezithile zokudla okugcwele ekuzinziweni kwayo, okusindayo noma ngefilimu ukwakha izakhiwo.
Isikhathi sePosi: Feb-15-2025