Ngabe i-HPMC ingancibilikisa emanzini ashisayo?

I-HPMC (Hydroxypropyl Methylcellulose) iyindlela esetshenziswayo esetshenziswa amanzi iselula, esetshenziswa kabanzi ekwakheni, ukugqoka, umuthi, ukudla kanye nezinye izimboni. Itholakala ngokuguqulwa kwamakhemikhali kwe-cellulose yemvelo. Izici zalo zesakhiwo zivumela ukuthi kwakhiwe isisombululo esiphakeme kakhulu emanzini futhi kube ne-solubility ethile.

Ngabe i-HPMC ingancibilikisa emanzini ashisayo?
I-HPMC ingancibilika emanzini ashisayo, kepha inqubo yayo yokuchithwa ihlobene kakhulu nezinto ezifana nokushisa, izinga lokushisa lamanzi lokuchithwa, isisindo se-hpmc, kanye ne-degree yokuguqulwa. Ngokuvamile, i-HPMC ingancibilika ekushiseni kwegumbi, kepha izinga lokuchithwa lizoshesha emazingeni okushisa aphezulu.

1. Indlela yokuchithwa
Indlela yokuqothula i-HPMPC emanzini ikakhulukazi incike nge-hydrophicity yamaqembu we-hydroxyl kanye ne-methyl namaqembu ePropells kuma-molecule awo. Ama-molecule wamanzi angasebenzisana namaqembu we-hydroxyl kanye ne-methyl kuma-molecule we-hpmc ngama-hydrogen bond, ukuze amaketanga we-cellulose athululwa futhi ekugcineni asungulwa isixazululo somfaniswano. Ngakho-ke, i-HPMC ine-solubility enhle yamanzi.

2. Umphumela wokushisa okuchithekile ekuhlanzeni kwe-HPMC
I-solubity ye-HPMC imvamisa yanda ngokushisa okuzayo. Ngaphansi kwezimo zokushisa eziphakeme, amandla e-kinetic ama-molekyuli amanzi ayanda, futhi angaxhumana ngempumelelo namaqembu we-hpdrophilic kuma-molecule we-HPMC, ngaleyo ndlela esheshisa inqubo yabo yokuchitheka. Ikakhulu nge-HPMC enesisindo esiphakeme samangqamuzana, amanzi ashisayo angakusiza kuncibilike ngokushesha okukhulu.

Kodwa-ke, ukusonta kwe-HPMC akunakuxhomekeka kumazinga okushisa, kepha nasendleleni yayo yokuguqulwa. Izilinganiso zeqembu elihlukile lamakhemikhali ku-molecule ye-HPMC zithinta i-solubility yayo yamanzi kanye nezinga lokuchithwa. Isibonelo, i-HPMC enokuqukethwe okuphezulu kwe-hydroxypropyl ine-hydrophicility eqinile futhi ngenxa yalokho chitha ngokushesha emanzini.

3. Umphumela wokushisa okuphezulu ngezinga lokuchithwa
Emazingeni okushisa aphezulu, izinga lokuchithwa kwe-HPMC lizosheshisa kakhulu. Ikakhulu, ebangeni lama-60 ° C kuye ku-90 ° C, izinga lokuchithwa kwe-HPMC lathuthukiswa kakhulu. Lokhu kungenxa yokuthi amanzi ashisayo angabhubhisa ngempumelelo izibopho ze-hydrogen phakathi kwama-molecule, avumele ama-molecule wamanzi ukungena ohlelweni lwamamolekli we-HPMC ngokushesha, ngaleyo ndlela akhuthaze ukuchithwa kwawo.

4. Izinkinga ezingahlangatshezwa ngesikhathi sokuchithwa
Yize i-HPMC ingachithwa emanzini ashisayo, uma izinga lokushisa liphezulu kakhulu, i-HPMC esixazululweni ingahle ibe nokonakaliswa okuthile noma okuhlelekile lapho kuvezwa amazinga okushisa aphezulu isikhathi eside. Lokhu kungathinta ukubonakala kwayo nokusebenza kwayo, ikakhulukazi kwezinye izindawo zohlelo lokusebenza, lolu shintsho lungaba nomthelela kwikhwalithi yomkhiqizo wokugcina.

Uma izinga lokushisa lamanzi elingezwe ngesikhathi senqubo yokuchithwa liphezulu kakhulu, i-hpmc powder ingakha izinhlayiyana agglomerates emanzini, okuphumela ekuchithekeni okungaphelele. Ngakho-ke, ukuze kuqinisekiswe ukuchithwa okuphelele kwe-HPMC, kuvame ukunconyelwa ukusebenzisa amanzi afudumele ngesikhathi sokuchithwa futhi kwamukele izindlela ezifanele zokuqothula noma izindlela ze-ultrasonic ezisizwayo.

Izibonelo zohlelo lokusebenza lokuchithwa kwamanzi okushisayo kwe-HPMC
Kuzinhlelo zokusebenza ezisebenzayo, i-solubity yamanzi eshisayo ye-HPMC ivame ukusetshenziswa. Isibonelo, embonini yezokwakha, i-HPMC, njengokuhlanganiswa okubalulekile, kunganikeza i-Rhesion ebaluleke kakhulu, ukunamathela kanye nokugcinwa kwamanzi ngokuphendula ngamanzi. Lapho ulungiselela usimende we-slurry noma udaka, i-hpmc ingasiza ukuthuthukisa ukusebenza kokwakha futhi ivikele ukuqhekeka.

Embonini yezemithi, i-HPMC isetshenziswa kabanzi ekwakheni ama-ejenti wokukhipha okuqhubekayo kanye nama-capsule amagobolondo ezidakamizwa. Ngenxa ye-solubility yayo enhle, i-hpmc ingancibilika kancane emzimbeni womuntu futhi ikhiphe izithako zezidakamizwa. Kule nqubo, izinga lokushisa lamanzi kanye nezinga lokuchithwa kwe-HPMC lidlala indima ebalulekile.

Embonini yokudla, i-HPMC, njengesengezo sokudla, imvamisa isetshenziswa njengesikhulu, i-emulsifier, njll. Ngemuva kokuncibilika emanzini ashisayo, inganikeza ukubonwa okufisayo kanye nokuthungwa, ukuthuthukisa ukunambitheka nokuqina kokudla.

I-HPMC ingachithwa emanzini ashisayo, futhi i-solubelity yayo ihlobene nokushisa kwamanzi, isakhiwo samangqamuzana se-HPMC, isisindo samangqamuzana kanye nokuguqulwa kwamakhemikhali. Emazingeni okushisa aphezulu, izinga lokuchithwa lishesha, imvamisa ebangeni lama-60 ° C kuye ku-90 ° C, umphumela wokuchitheka ungcono kakhulu. Lapho usebenzisa amanzi ashisayo ukuncibilikisa i-HPMC, kuyadingeka ukunaka ukulawula izinga lokushisa lamanzi nokuchithwa kwesikhathi sokugwema umthelela ongemuhle wamazinga okushisa aphezulu ngokweqile ekusebenzeni kwawo ngokweqile ekusebenzeni kwawo ngokweqile.