Ingabe i-hydroxypropyll methylcellulose kanye ne-hypromellose efanayo?

I-Hydroxypropyl Methylcellulose (HPMC) kanye ne-Hypromellose yimigomo evame ukusetshenziswa ngokushintshana, kepha abhekisela entweni efanayo. I-HPMC ingukususelwa kokwenziwa kwe-cellulose, kanye ne-hypromellose yigama elingelona elemhlaba (inn) lale nhlanganisela. Lawa magama asetshenziswa kakhulu kwizimboni zemithi kanye nokudla, phakathi kwabanye, ngenxa yezindawo zabo eziguquguqukayo.

I-Hydroxypropyl Methylcellulose (HPMC) / Isakhiwo se-Hypromellose:

I-Hydroxypropylm methylcellulose iyinhlangano eguquliwe ye-cellulose polymer. Ukulungiswa kufaka ukungezwa kwe-hydroxypropyl kanye namaqembu we-methoxy ku-cellulose backbone. I-Cellulose ingukuvela ngokwemvelo ama-polysaccharide ahlanganiswe ama-glucose amayunithi axhumeke ama-β-1,4-glycosidic bond. Ukwethulwa kwe-Hydroxyproppropylyl (-Hoch2ch (oh) Ch3) kanye ne-methoxy (-Och3 (-Och3) amaqembu anika i-purellose ahlukahlukene, athuthukise i-solubity yayo, ukuhlakanipha nezinye izakhiwo.

Izinga lokufaka esikhundleni (DS) lisho inani eliphakathi lokufakwa esikhundleni kweyunithi ngayinye ye-Anhydroglucose eCellulose Chain. Endabeni ye-HPMC, ukuhlukahluka ku-DS kungahle kube nomphumela kumabanga ahlukene ngezakhiwo ezahlukahlukene, kubenza basebenzise izinto eziguquguqukayo zezinhlelo zokusebenza ezihlukile.

Izici ze-Hydroxypropyllym methylcellulose:
I-Solubity kanye nokwakheka kwejeli:
I-HPMC iyancibilika emanzini ngaphezulu kobubanzi bokushisa, kanye nokuzinikela kuncike ezintweni ezifana nezinga lokufaka esikhundleni kanye nesisindo se-molecular. Ukuba khona kwe-Hydroxypropyl kanye namaqembu we-methoxy kunomthelela ekubolekeni kwamanzi abandayo, okwenza kulungele ukusetshenziswa ekwakhiweni okuhlukahlukene.

I-Viscosity:
Enye yezinto ezibalulekile ze-HPMC yikhono layo lokushintsha i-viscosity yesisombululo. Amabanga ahlukene we-HPMC anama-visosities ahlukene atholakala ngokuya ngezidingo ezithile zokwakhiwa.

Ifilimu Yakha Izakhiwo:
I-HPMC yakha amafilimu acacile futhi avumelana nezimo, okwenza kube yigugu kuzinhlelo zokusebenza ze-coating kwizimboni zezemithi nokudla. Izakhiwo ezenziwe ngefilimu zibaluleke kakhulu ekukhiqizeni amafomu omthamo oqinile womlomo kanye nama-confectionery coating.

Stuabilize:
I-HPMC ikhombisa ukuqina ngaphezulu kwebanga elibanzi le-PH, okufaka isandla ekuguquguqukeni kwayo ekwakhiweni okuhlukile. Imelana nokuwohloka kwe-enzymatic kanye nokuhlaselwa yi-microbial, ukuqinisekisa ukuqina kwemikhiqizo yezemithi.

Izicelo zezemithi:
I-Tablet Coating:
I-HPMC isetshenziswa kabanzi emkhakheni wezemithi ukuze uthole ukuhlanganiswa kwethebhulethi. I-Film Coatings isebenza ngezinhloso ezahlukahlukene, kufaka phakathi ukumangala kokunambitha, ukuvikela izidakamizwa ezingozini zezemvelo, nokukhishwa okulawulwa.

Ukulungiselela ukukhishwa okuqhubekayo:
Ukukhishwa kwezidakamizwa okulawulwayo nokuqhubekayo kuyisici esibalulekile sokuthuthuka kwezidakamizwa. I-HPMC isetshenziselwa ukwakha izinhlelo ze-matrix ezivumela ukukhululwa kancane kwezithako ezisebenzayo zemithi (API) esikhathini eside.

Amalungiselelo we-Ophthalmic:
Ezakhiweni ze-ophthalmic, i-HPMC isetshenziselwa ukukhulisa i-viscosity yamaconsi eso futhi welula isikhathi sokuxhumana ne-ocular. Lokhu kuthuthukisa umphumela wokwelapha umuthi.

Izicelo ze-Topical and Transdermal:
I-HPMC ifakwa ekwakhiweni kwe-topical okufana nama-gels nokhilimu ukuhlinzeka ngokubonakala futhi kuthuthukise ukusakazeka komkhiqizo. Kusetshenziswa futhi kuma-transdermal patches ukulawula ukukhishwa kwezidakamizwa ngesikhumba.

Uketshezi lomlomo:
I-Hydroxypropyl methylcellulose isetshenziswa ekwakhiweni kwamafomu we-dollage omlomo womlomo ukuze athuthukise ukubonakala, amise izinhlayiya, futhi athuthukise ukuqina.

Izicelo Zomkhakha Wokudla:
I-Shirener:
I-HPMC isetshenziswa njenge-ejenti yokuqina emikhiqizweni yokudla ehlukahlukene, kufaka phakathi amasoso, ukugqoka kanye nama-dessert. Amandla awo okushintsha ukubonakala kusiza umkhiqizo wokugcina uzuze ukuthungwa okufunayo.

I-Shirener:
Kwezinye izinhlelo zokusebenza zokudla, i-HPMC ingasebenza njenge-ejenti ye-gelling, isiza ukwakha ama-gels noma i-Standamisa emulsions.

Ingilazi kanye nezimbali:
I-HPMC isetshenziswa ezindabeni zokudla kanye nezimbobo zokuthuthukisa ukunamathela, ukubukeka nokugcinwa komswakama. Kwakha ifilimu esobala ethuthukisa ukukhanga okubonakalayo kwemikhiqizo yokudla.

Ukufakwa esikhundleni samafutha:
Njenge-hydrocolloid, i-HPMC ingasetshenziswa njengendawo ebambekayo ethandweni lokudla lamafutha aphansi noma lamafutha, ukuhlinzeka ukuthungwa kanye nomlomo okufana nemikhiqizo enokuqukethwe kwamafutha aphezulu.

IZINSELELE NOKUFUNDA:
Ngenkathi i-hydroxypropyllllllyllose iyinto eguquguqukayo enezinto ezahlukahlukene zezicelo, kukhona ukucatshangelwa kanye nezinselelo isicelo sayo:

Ukuzwakala kokushisa:
I-solubity ye-HPMC iyathinteka ekushiseni. Amanye amabanga angahle abonise ukuncipha kwe-soubelity emazingeni okushisa aphezulu, adinga ukucubungula ngokucophelela ekwakhekeni.

I-Hygroscopicity:
I-HPMC i-hygroscopic, okusho ukuthi idonsa kalula umswakama evela emvelweni. Le mpahla idinga ukubhekwa ekwakhekeni lapho okuqukethwe umswakama kubalulekile.

Ukuvumelana kwezidakamizwa:
Ezisetshenzisweni zemithi, ukuhambisana phakathi kwezidakamizwa ne-polymer kubalulekile ukuqinisekisa ukuqina kanye nokusebenza kahle komkhiqizo wokugcina.

Isimo Sokulawula:
IHydroxypropyllylyl methylcellose yamukelwa kabanzi futhi yavunywa yizinhlangano ezilawulayo ezifana nokudla kwe-US Food and Drug Administration (FDA) kanye ne-European Medicines Agency Agency (EMA). Kubhalwe e-pharmacopoeia njenge-excipie ehlonishwayo yamalungiselelo emithi.

I-Hydroxypropyl methylcellulose, eyaziwa ngokuthi i-Hypromellose, iyinhlangano yama-polymer eminingi enezinhlelo eziningi ezinobubanzi kwizimboni zezemithi nokudla. Izakhiwo zayo ezihlukile, kufaka phakathi i-soubity, ukuguquguquka kwe-viscosity, ikhono elakha amafilimu nokuqina, kwenze kube nezithako ezibalulekile ezinhlobonhlobo zokwakheka.

Ukusuka ku-Tablet Coatings kanye nokwakhiwa okunwetshiwe okuphezulu ezinhlamvini kuya kubakhudlwana namafutha embonini yokudla, i-HPMC idlala indima ebalulekile ekuthuthukiseni ukusebenza kanye nezakhiwo zemikhiqizo ehlukahlukene. Amandla okuvumelanisa izakhiwo zawo ngokulungisa izinga lokufakwa esikhundleni kanye nesisindo se-molecular anikela ngokuguquguquka kwalo ngezicelo ezihlukile.