I-Hydroxyproppropylls efakwe esikhundleni kakhulu (HS-HPC) iyi-excipose enezinzuzo ezibalulekile enkundleni yezemithi. Ngenxa yezakhiwo zayo zamakhemikhali ezihlukile nezingokomzimba, zidlala indima ebalulekile ekwakhekeni kwemithi.
1. I-solubity kanye ne-solubility yamanzi
Ukulawulwa okulawulwayo
I-hydroxyproppropylls efakwe esikhundleni kakhulu ine-soubelity enhle emanzini futhi ingancibilika ngokushesha ukwakha isixazululo esiphezulu. Le phrofayili ye-solubity yenza kube kuhle kakhulu ekuhlelweni kokwakhiwa komlomo, okujova, kanye nezicelo ze-topical. Emakhishini ezidakamizwa, izinga lokuchithwa kwe-HS-HPC lingalawulwa ngokulungisa izinga lokufaka esikhundleni samaqembu e-hydroxypropyl ukuze ahlangabezane nezidingo ezahlukahlukene zezidakamizwa.
Umphumela Wokungena
I-HS-HPC ingakhuphula i-solubility yezidakamizwa ezithile ze-hydrophobic, ngaleyo ndlela zithuthukise ukungatholakali kwezidakamizwa. Lokhu kubaluleke kakhulu kulezo zidakamizwa ezingenampilo ezingezincinya, ezingathuthukisa i-solubity yazo nokumunca ngokwakha izakhiwo ezincibilikisiwe.
2. Ukulungiswa kwe-Viscosity kanye ne-Rheological Properties
Ukulungiswa kwe-Viscosity
I-HS-HPC iyakwazi ukwakha izixazululo ze-viscous kakhulu emanzini, impahla evumela ukuthi isetshenziswe njenge-spilizer enkulu kanye nokumiswa. Isibonelo, ekumisweni kokumiswa komlomo, kungavimbela ngempumelelo izinhlayiya eziqinile ekuxazululeni, qinisekisa ukusatshalaliswa okufanayo kwezidakamizwa, futhi kuthuthukiswe umuzwa wemithi yeziguli.
Ukulungiswa kwe-hehelogy
Isixazululo se-HS-HPC sine-Pseudoplallimaty, okungukuthi, i-viscosity izokwehla ngaphansi kwesenzo se-Shear Force. Le mpahla ibaluleke kakhulu ezinjoleka ngoba inciphisa ukumelana ngesikhathi somjovo futhi ithuthukise induduzo yesiguli.
3. Izakhiwo ezenziwe ngeFilm ne-Adhesion
Ifilimu Yakha Izakhiwo
Izakhiwo ezenziwe ngefilimu ze-HS-HPC zenza ukuthi isetshenziswe kabanzi ekuguqukeni kwamafilimu okulawulwa. Kungakha ifilimu efanayo nezinzile ukusiza ukulawula isilinganiso sokukhishwa kwezidakamizwa nokwenza ngcono ukusebenza kwezidakamizwa. Le mpahla ibaluleke kakhulu kumathebulethi akhululwe ngomlomo namaphilisi, anganwebeka kakhulu isikhathi sokusebenza kwesidakamizwa futhi anciphise imvamisa ye-dosing.
Izakhiwo zokunamathela
Izakhiwo ezinhle zokunamathela ze-HS-HPC zikwenza kahle kumalungiselelo wokutholwa kwe-mucosal. Isibonelo, kumafilimu omlomo kanye namalungiselelo okukhishwa kwe-mucosal okugciniwe, i-HS-HPC inganamathela ngempumelelo endaweni ye-mucosal ukuze aqinisekise ukukhishwa kwasendaweni kanye nokufakwa kwesidakamizwa.
4. Ukuqina kanye nokuqina
ukuqina kwamakhemikhali
I-HS-HPC inokuqina okuhle kwamakhemikhali, kuhlala kuzinzile ngaphezu kobubanzi be-PH, futhi akuthambekele ku-hydrolysis noma ukucekelwa phansi. Lokhu kuzinza kukusiza ukuthi uhlale uphumelele ekwakhekeni kwezidakamizwa ezahlukahlukene, uqinisekise ukuqina kwesikhathi eside nokuphepha kwesidakamizwa.
biocomthation
I-HS-HPC ine-biocomtic enhle futhi ingahlangana ngokuvumelanayo izicubu zomzimba kanye noketshezi lomzimba ngaphandle kokubangela ukusabela komzimba noma ukucasuka. Lokhu kwenza i-HS-HPC isetshenziswe kabanzi ezinhlobonhlobo zamalungiselelo amakhambi, ikakhulukazi ezidakamizweni ze-ophthalmic nemijovo, ukuqinisekisa ukuphepha nokusebenza kwezidakamizwa.
I-5. Inqubo yokuguquguquka nokuguquguquka okuhlukahlukene
Inqubo yokuguquguquka
I-HS-HPC ilungele izinqubo ezahlukahlukene zokuqamba, kufaka phakathi ukomisa kwesifutho, ukugcotshwa okumanzi nokuncipha kokuncibilikisa. Inqubo yayo enhle yenqubo inika amandla ukusetshenziswa okuguquguqukayo ezinqubweni zezemithi, ithuthukisa ukusebenza kahle kokukhiqiza futhi yehlise izindleko.
Ububanzi
I-HS-HPC iyasebenza njenge-Exepieutietical Execipietical. Akunakusetshenziswa kuphela njenge-binder kanye nesikhulu, kepha futhi njenge-ejenti eyakha ifilimu ne-stabilizer. Lokhu kuguqulwa kwenza i-HS-HPC ikwazi ukusebenza ekwakhekeni okuhlukahlukene kwemithi, ukwenza lula ukwakheka kokwakheka nokwenza ngcono ukusebenza kahle kokukhiqiza.
6. Ukusebenza okulawulwa okulawulwayo kanye nokulawulwa kwezidakamizwa
Izici Zokukhishwa Ezilawulile
I-HS-HPC ingafinyelela ukukhishwa okulawulwa kwezidakamizwa ngokwakha inethiwekhi exhumeke ngokuqondile noma yakha okuyinkimbinkimbi ngezidakamizwa. Le mpahla yokukhishwa elawulwayo ibaluleke kakhulu kumathebulethi okukhishwa okuqhubekayo kanye nama-caplule, anganwebeka kakhulu isikhathi sesenzo somuthi futhi athuthukise ukulandelwa kweziguli.
Ukulawulwa Kwezidakamizwa
Ngokushintsha isisindo se-molecular, degree of inqumetha, kanye ne-solubility ye-HS-HPC, isilinganiso sokukhishwa kwezidakamizwa singaba elawulwa ngqo. Leli khono lokulawula ukukhishwa kwezidakamizwa linika amandla onjiniyela abakhamisha ukuklama ukwakhiwa kwezidakamizwa okuhlangabezana nezidingo zokwelashwa okuthile futhi kuthuthukise ukusebenza kwezidakamizwa.
7. Ubungane bezemvelo kanye nokulimazeka
I-HS-HPC isuselwa ku-cellulose yemvelo futhi ine-biodegradeamatiness enhle kanye nobungane bezemvelo. Ingadilizwa ama-microorganisms ezintweni ezilimazayo ngaphakathi nangaphandle komzimba, ohlangabezana nezidingo zamakhambi anamuhla okuluhlaza futhi anciphise ingozi yokungcoliswa kwemvelo.
I-hydroxyproppropyllopyls efakwe esikhundleni kakhulu inezinzuzo ezibalulekile ezisetshenzisweni zemithi, kufaka phakathi i-soubity enhle, ukulungiswa kwefilimu, ukuqina kwamafilimu, ukuguquguquka kwezinguquko, ukuguquguquka kwezinguquko, ukusebenza kwezindlela ezilawulwayo, kanye nobungane bezemvelo. Lezi zici zenza i-HS-HPC ibe yikhiye obaluleke kakhulu embonini yezemithi embonini yezemithi, enikeza ukusekelwa okuqinile kokuthuthukiswa kwamalungiselelo asebenzayo, aphephile, nawomile namakhambi.
Isikhathi sePosi: Feb-17-2025